Distribution of MUC1 in the normal human oral cavity is localized to the ducts of minor salivary glands

Archives of Oral Biology

Volumn 46, Issue 6, 2001, Pages 529-538

  Sengupta, Anita ^a   Valdramidou, Dimitra ^a   Huntley, Suzanne ^b   Hicks, Sally J ^a   Carrington, Stephen D ^a   Corfield, Anthony P ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b Division of Oral Medicine   (United Kingdom)

Author keywords

Minor salivary gland; MUC1; Mucin; Oral mucosa

Indexed keywords

ANTIBODY; BIOLOGICAL MARKER; CA 15 3 ANTIGEN; CA 15-3 ANTIGEN; DETERGENT; GLUCOSIDE; MESSENGER RNA; MUCIN; OCTYL BETA GLUCOSIDE; OCTYL-BETA-D-GLUCOSIDE; SAPONIN;

ARTICLE; CELL MEMBRANE; DENSITY GRADIENT CENTRIFUGATION; GLYCOCALYX; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MINOR SALIVA GLAND; MOUTH MUCOSA; NORMAL HUMAN; PAROTID GLAND; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SALIVARY GLAND DUCT; SUBMANDIBULAR GLAND;

ANTIBODIES; BIOLOGICAL MARKERS; CA-15-3 ANTIGEN; CELL MEMBRANE; CENTRIFUGATION, ISOPYCNIC; DETERGENTS; GLUCOSIDES; GLYCOCALYX; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MOUTH MUCOSA; PAROTID GLAND; RNA, MESSENGER; SALIVARY DUCTS; SALIVARY GLANDS, MINOR; SAPONINS; SUBMANDIBULAR GLAND;

EID: 0035010687     PISSN: 00039969     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-9969(01)00010-3     Document Type: Article

References (56)

1. Aplin J.D., Hey N.A. MUC1, endometrium and embryo implantation. Biochem. Soc. Trans. 23:1995;826-830.
2. Audie J.P., Janin A., Porchett N., Copin M.C., Gosselin B., Aubert J.P. Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridisation. J. Histochem. Cytochem. 41:1993;1479-1485.
3. Bobek L.A., Tsai H., Biesbrock A.R., Levine M.J. Molecular cloning, sequence and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7). J. Biol. Chem. 268:1993;20563-20569.
4. r mucins secreted by different human salivary glands discriminated by density-gradient electrophoresis. Biochem. J. 309:1995;801-806.
5. Bordier C. Phase separation of integral membrane proteins in Triton X-114 solution. J. Biol. Chem. 25:1981;1604-1607.
6. Boros I., Keszler P., Zelles T. Study of saliva secretion and the salivary fluoride concentration of human minor labial glands by a new method. Arch. Oral Biol. 44:1999;S59-S62.
7. Carlstedt I., Lindgren H., Sheehan J.K., Ulmsten U., Wingerup L. Isolation and characterization of human cervical-mucus glycoproteins. Biochem. J. 211:1983;13-22.
8. Cerneus D.P., Ueffing E., Posthuma G., Strous G.J., van der Ende A. Detergent insolubility of alkaline phosphatase during biosynthetic transport and exocytosis. J. Biol. Chem. 268:1993;3150-3155.
9. Collan Y., Raeste A.M. Electron microscopy of exfoliated cells of human oral mucosa. Scand. J. Dent. Res. 86:1978;374-385.
10. Collins L.M.C., Dawes C. The surface area of the adult human mouth and thickness of the salivary film covering the teeth and oral mucosa. J. Dent. Res. 66:1987;1300-1302.
11. Corfield A.P., Paraskeva C. Secreted mucus glycoproteins in cell and organ culture. Hounsell E. Glycoprotein Analysis in Biomedicine. 14:1993;211-232 Humana Press, Totowa.
12. Dabelsteen E. Receptors on the keratinocyte surface. Meyer J., Squier C.A., Gerson S.J. The Structure and Function of Oral Mucosa. 1984;83-93 Pergamon Press, Oxford.
13. Dabelsteen E., Clausen H., Mandel U. Aberrant glycosylation in oral malignant and premalignant lesions. J. Oral Pathol. Med. 20:1991;361-368.
14. Dawes C., Wood C.M. The contribution of oral minor mucous gland secretions to the volume of whole saliva in man. Arch. Oral Biol. 18:1973;337-342.
15. Duffy M.J. CA 15-3 and related mucins as circulating markers in breast cancer. Ann. Clin. Biochem. 36:1999;579-586.
16. Findlay J.B.C. The isolation and labelling of membrane proteins and peptides. Findlay J.B.C., Evans W.H. Biological Membranes: A Practical Approach. 1987;179-217 ICL Press at OUP, Oxford.
17. Gendler S.J., Spicer A.P. Epithelial mucin genes. Annu. Rev. Physiol. 57:1995;607-634.
18. Gipson I.K., Inatomi T. Mucin genes expressed by the ocular surface epithelium. Prog. Retinal Eye Res. 16:1997;81-98.
19. Hand A.R., Pathmanathan D., Field R.B. Morphological features of the minor salivary glands. Arch. Oral Biol. 44:1999;S3-S10.
20. Harris M., Vasudev K.S., Anfield C., Wells S. Mucin-producing carcinomas of the breast: ultrastructural observations. Histopathology. 2:1978;177-188.
21. Hartman M.L., Baruch A., Ron I., Aderet Y., Yoeli M., Sagi Assif O., Greenstein S., Stadler Y., Weiss M., Harness E., Yaakobovitz M., Keydar I., Smorodinsky N.I., Wreschner D.H. MUC1 isoform specific monoclonal antibody 6E6/2 detects preferential expression of the novel MUC1/Y protein in breast and ovarian cancer. Int. J. Cancer. 82:1999;256-267.
22. Hay D.I., Bowen W.H. The functions of salivary proteins. Edgar W.M., O'Mullane D.M. Saliva and Oral Health. 1996;105-122 British Dental Association, London.
23. Hey N.A., Li T.C., Devine P.L., Graham R.A., Saravelos H., Aplin J.D. MUC1 in secretory phase endometrium: expression in precisely dated biopsies and flushings from normal and recurrent miscarriage patients. Hum. Reprod. 10:1995;2655-2662.
24. Hicks S.J., Carrington S.D., Kaswan R.L., Adam S., Bara J., Corfield A.P. Demonstration of discrete secreted and membrane-bound ocular mucins in the dog. Exp. Eye Res. 64:1997;597-607.
25. Hilkens J., Ligtenberg M.J.L., Vos H.L., Litvinov S.V. Cell membrane-associated mucins and their adhesion-modulating property. Trends Biochem. Sci. 17:1992;359-363.
26. Lancaster C.A., Peat N., Duhig T., Wilson D., Taylor-Papadimitriou J., Gendler S.J. Structure and expression of the human polymorphic epithelial mucin gene: an expressed VNTR unit. Biochem. Biophys. Res. Commun. 173:1990;1019-1029.
27. Masaki Y., Oka M., Ogura Y., Ueno T., Nishihara K., Tangoku A., Takahashi M., Yamamoto M., Irimura T. Sialylated MUC1 mucin expression in normal pancreas, benign pancreatic lesions, and pancreatic ductal adenocarcinoma. Hepato-gastroenterology. 46:1999;2240-2245.
28. May D.P.J., Sloan P. Lectin binding to normal mucosa, leukoplakia and squamous cell carcinoma of the oral cavity. Med. Lab. Sci. 48:1991;6-18.
29. Nagata Y., Burger M.M. Wheat germ agglutinin - molecular characteristics and specificity for sugar binding. J. Biol. Chem. 249:1974;3116-3122.
30. Newland J.R., Jacob R., McDaniel R.K., Durban E.M. MUC-1 Mucin immunodetection in human salivary glands. J. Dent. Res. 76:(No. SISI):1997;2632.
31. Nielsen P.A., Bennett E.P., Wandall H.H., Therkildsen M.H., Hannibal J., Clausen H. Identification of a major human high molecular weight salivary mucin (MG1) as tracheobronchial mucin MUC5B. Glycobiology. 7:1997a;413-419.
32. Nielsen P.A., Mandel U., Therkildsen M.H., Ravn V., David L., Reis C.A., Wandell H.H., Dabelsteen E., Clausen H. Loss of a novel mucin-like epithelial glycoprotein in oral and cervical squamous cell carcinoma. Cancer Res. 57:1997b;634-640.
33. Nieuw Amerongen A.V., Bolscher J.G.M., Veerman E.C.I. Salivary mucins: protective functions in relation to their di versity. Glycobiology. 5:1995;733-740.
34. Ogden G.R., Cowpe J.G., Wight A.J. Oral exfoliative cytology: review of methods of assessment. J. Oral Pathol. Med. 26:1997;201-205.
35. Patton S., Gendler S.J., Spicer A.P. The epithelial mucin, MUC1, of milk, mammary gland and other tissues. Biochim. Biophys. Acta. 1241:1995;407-424.
36. Quintarelli G., Tsuiki S., Hashimoto Y., Pigmen W. Histochemical studies of bovine salivary glands. Biochem. Biophys. Res. Commun. 2:1960;423-426.
37. Saussez S., Marchant H., Nagy N., Decaestecker C., Hassid S., Jortay A., Schüring M.P., Gabius H.J., Danguy A., Salmon I., Kiss R. Quantitative glycohistochemistry defines new prognostic markers for cancers of the oral cavity. Cancer. 82:1998;252-260.
38. Schroeder H.E. Oral mucosa. Oral Structural Biology. 1991;350-391 Georg Thieme Verlag, Stuttgart.
39. Seregni E., Botti C., Bajetta E., Ferrari L., Martinetti A., Nerini-Molteni S., Bombardieri E. Hormonal regulation of MUC1 expression. Int. J. Biol. Markers. 14:1999;29-35.
40. Simons K., Ikonen E. Functional rafts in cell membranes. Nature. 387:1997;569-572.
41. Sivarajasingam V., Drummond J.R. Measurements of human minor salivary-gland secretions from different oral sites. Arch. Oral Biol. 40:1995;723-729.
42. Smorodinsky N., Weiss M., Hartmann M.L., Baruch A., Harness E., Yaakobovitz M., Keydar I., Wreschner D.H. Detection of a secreted MUC1/SEC protein by MUC1 isoform specific monoclonal antibodies. Biochem. Biophys. Res. Commun. 228:1996;115-121.
43. Strous G.J., Dekker J. Mucin-type glycoproteins. Crit. Rev. Biochem. Mol. Biol. 27:1992;57-92.
44. Sugarman P.B., Savage N.W. Exfoliative cytology in clinical oral pathology. Austr. Dent. J. 41:1996;71-74.
45. Tabak L.A. In defence of the oral cavity: structure, biosynthesis, and function of salivary mucins. Annu. Rev. Physiol. 57:1995;547-564.
46. Tatemoto Y., Saka M., Tanimura T., Mori M. Immunohistochemical observations on binding of monoclonal antibody to epithelial membrane antigen in epithelial tumors of the oral cavity and skin. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endodont. 64:1987;721-726.
47. Ten Cate A.R. Oral mucosa. Oral Histology: Development, Structure and Function. 1998;345-385 Mosby, St. Louis, MO.
48. Thornton D.J., Holmes D.F., Sheehan J.K., Carlstedt I. Quantitation of mucus glycoproteins blotted onto nitrocellulose membranes. Anal. Biochem. 182:1989;160-164.
49. Thornton D.J., Khan N., Mehrotra R., Howard M., Veerman E., Packer N.H., Sheehan J.K. Salivary mucin MG1 is composed almost entirely of different glycosylated forms of the MUC5B gene product. Glycobiology. 9:1999;293-302.
50. Veerman E.C.I., Bank C.M.C., Namavar F., Appelmelk B.J., Bolscher J.G.M., Nieuw Amerongen A.V. Sulphated glycans on oral mucin as receptors for Helicobacter pylori. Glycobiology. 7:1997;737-743.
51. Vigneswaran N., Peters K.P., Hornstein O.P., Diepgen T.L. Alteration of cell surface carbohydrates associated with ordered and disordered proliferation of oral epithelia: a lectin histochemical study in oral leukoplakias, papillomas and carcinomas. Cell Tiss. Kinet. 23:1990;41-55.
52. Wickström C., Davies J.R., Eriksen G.V., Veerman E.C.I., Carlstedt I. MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: identification of glycoforms and C-terminal cleavage. Biochem. J. 334:1998;685-693.
53. Xing P.X., Tjandra J.J., Stacker S.A., Teh J.G., Thompson C.H., McLauglin P.J., McKenzie I.F. Monoclonal antibodies reactive with mucin expressed in breast cancer. Immunol. Cell Biol. 67:1989;183-195.
54. Zotter S., Lossnitzer A., Kunze K.D., Muller M., Hilkens J., Hilgers J., Hageman P. Epithelial markers for paraffin-embedded human tissues. Virchows Archiv. 406:1985;237-251.
55. Zotter S., Hageman P.C., Lossnitzer A., van den Tweel J., Hilkens J., Mooi W.J., Hilgers J. Monoclonal antibodies to epithelial sialomucins recognize epitopes at different cellular sites in adenolymphomas of the parotid gland. Int. J. Cancer. Suppl. 3:1988;38-44.
56. Zrihan-Licht S., Vos H.L., Baruch A., Elroy-Stein O., Sagiv D., Keydar I., Hilkens J., Wreschner D.H. Characterization and molecular cloning of a novel MUC1 protein, devoid of tandem repeats, expressed in human breast cancer tissue. Eur. J. Biochem. 224:1994;787-795.