Loss of a novel mucin-like epithelial glycoprotein in oral and cervical squamous cell carcinomas

Cancer Research

Volumn 57, Issue 4, 1997, Pages 634-640

  Nielsen, Peter A ^a   Mandel, Ulla ^a   Therkildsen, Marianne H ^b   Ravn, Vibeke ^b,c   David, Leonor ^d   Reis, Celso A ^a,d   Wandall, Hans H ^a   Dabelsteen, Erik ^a   Clausen, Henrik ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Rigshospitalet   (Denmark)

^c FREDERIKSBERG HOSPITAL   (Denmark)

^d UNIVERSITY OF PORTO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

MUCIN LIKE CARCINOMA ASSOCIATED ANTIGEN;

ANTIGEN DETECTION; ANTIGEN EXPRESSION; ARTICLE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MOUTH CARCINOMA; MOUTH MUCOSA; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; SQUAMOUS CELL CARCINOMA; SQUAMOUS EPITHELIUM; UTERINE CERVIX CARCINOMA; UTERINE CERVIX EPITHELIUM;

ADULT; ANTIBODIES, MONOCLONAL; CARRIER PROTEINS; EPITOPES; FEMALE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MOUTH MUCOSA; MOUTH NEOPLASMS; MUCINS; MUCOUS MEMBRANE; NEOPLASM PROTEINS; UTERINE CERVICAL NEOPLASMS;

EID: 0031058772     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Gum, J. R., Jr. Mucin genes and the proteins they encode: structure, diversity, and regulation. Am. J. Respir. Cell Mol. Biol., 7: 557-564, 1992.
2. Shimizu, Y., and Shaw, S. Mucins in the mainstream. Nature (Lond.), 366: 630-631, 1993.
3. Schachter, H., and Brochausen, I. The biosynthesis of branched O-glycans. Symp. Soc. Exp. Biol., 43: 1-26, 1989.
4. Clausen, H., and Hakomori, S. ABH and related histo-blood group antigens: immunochemical differences in carrier isotypes and their distribution. Vox Sang., 56: 1-20, 1989.
5. Mandel, U., Petersen, O. W., Sørensen, H., Vedtofte, P., Hakomori, S. I., Clausen, H., and Dabelsteen, E. Simple mucin-type carbohydrates in oral stratified squamous and salivary gland epithelium. J. Invest. Dermatol., 97: 713-721, 1991.
6. Dabelsteen, E., Clausen, H., and Mandel, U. Aberrant glycosylation in oral malignant and premalignant lesions. J. Oral Pathol. Med., 20: 361-368, 1991.
7. Stubbe Teglhjærg, C., Ravn, V., Mandel, U., and Dabelsteen, E. Distribution of histo-blood group antigens in cervical and uterine endometrium. APMIS Suppl., 23: 100-106, 1991.
8. Brown, T. A., Bouchard, T., St. John, T., Wayner, E., and Carter, W. G. Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons. J. Cell Biol., 113: 207-221, 1991.
9. Oksala, O., Salo, T., Tammi, R., Hakkinen, L., Jalkanen, M., Inki, P., and Larjava, H. Expression of proteoglycans and hyaluronan during wound healing. J. Histochem. Cytochem., 43: 125-135, 1995.
10. Tatemoto, Y., Saka, M., Tanimura, T., and Mori, M. Immunohistochemical observations on binding of monoclonal antibody to epithelial membrane antigen in epithelial tumors of the oral cavity and skin. Oral Surg. Oral Med. Oral Pathol., 64: 721-726, 1987.
11. Kunikata, M., Yamada, K., Ogata, K., Mori, M., Tatemoto, Y., Osaki, T., Tubura, A., and Morii, S. Immunohistochemical evaluation of MAM-3 and MAM-6 antigens in squamous cell carcinoma of the oral cavity. Int. J. Oncol., 1: 753-758, 1992.
12. Clausen, H., Levery, S. B., Nudelman, E., Baldwin, M. and Hakomori, S. Further characterization of type 2 and type 3 chain blood group A glycosphingolipids from human erythrocyte membranes. Biochemistry, 25: 7075-7085, 1986.
13. Jeppe-Jensen, D., Clausen, H., Leigh, I. M., Lane, E. B., and Dabelsteen, E. Three monoclonal antibodies differentiate human from murine epidermis. Epithelial Cell Biol., 2: 100-106, 1993.
14. Clausen, H., Stroud, M., Parker, J., Springer, G., and Hakomori, S. Monoclonal antibodies directed to the blood group A associated structure, galactosyl-A: specificity and relation to the Thomsen-Friedenreich antigen. Mol. Immunol., 25: 199-204, 1988.
15. Young, W. W., Jr., Johnson, H. S., Tamura, Y., Karlsson, K. A., Larson, G., Parker, J. M., Khare, D. P., Spohr, U., Baker, D. A., Hindsgaul, O., and Lemieux, R. U. Characterization of monoclonal antibodies specific for the Lewis A human blood group determinant. J. Biol. Chem., 258: 4890-4894, 1983.
16. y). Biochemistry, 24: 6190-6194, 1985.
17. Wayner, E. A., and Carter, W. G. Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique alpha and common beta subunits. J. Cell Biol., 105: 1873-1884, 1987.
18. Taylor-Papadimitriou, J., Peterson, J. A., Arklie, J., Burchell, J., Ceriani, R. L., and Bodmer, W. F. Monoclonal antibodies to epithelium-specific components of the human milk fat globule membrane: production and reaction with cells in culture. Int J. Cancer, 28: 17-21, 1981.
19. Nielsen, P. A., Mandel, U., Therkildsen, M. H., and Clausen, H. Differential expression of human high molecular weight salivary mucin (MG1) and low molecular weight salivary mucin (MG2). J. Dent. Res., 75: 1820-1826, 1996.
20. WHO Collaborating Centre for Oral Precancerous Lesions. Definition of leukoplakia and related lesions: an aid to studies on oral precancerous lesions. Oral Surg. Oral Med. Oral Pathol., 46: 518-539, 1978.
21. Bara, J., Imberty, A., Pérez, S., Imai, K., Yachi, A., and Oriol, R. A fucose residue can mask the MUC-1 epitopes in normal and cancerous gastric mucosae. Int. J. Cancer, 54: 607-613, 1993.
22. Gerken, T. A., Gupta, R., and Jentoft, N. A novel approach for chemically deglycosylating O-linked glycoproteins. The deglycosylation of submaxillary and respiratory mucins. Biochemistry, 31: 639-648, 1992.
23. Tytgat, K. M., Swallow, D. M., Van Klinken, B. I., Buller, H. A., Einerhand, A. W., and Dekker, J. Unpredictable behaviour of mucins in SDS/polyacrylamide-gel electrophoresis. Biochem. J., 310: 1053-1054, 1995.
24. Gendler, S, J., and Spicer, A. P. Epithelial mucin genes. Annu. Rev. Physiol., 57: 607-634, 1995.
25. Hilkens, J., Ligtenberg, M. J. L., Vos, H. L., and Litvinov, S. V. Cell membrane- associated mucins and their adhesion-modulating property. Trends Biochem. Sci., 17: 359-363, 1992.
26. Moll, R., Franke, W. W., and Schiller, D. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell, 31: 11-24, 1982.
27. van Muijen, G. N. P., Ruiter, D. J., Franke, W. W., Achtstätter, T., Haasnoot, W. H. B., Ponec, M., and Warnaar, S. O. Cell type heterogeneity of cytokeratin expression in complex epithelia and carcinomas as demonstrated by monoclonal antibodies specific for cytokeratins nos. 4 and 13. Exp. Cell Res., 162: 97-113, 1986.
28. Morgan, P. R., and Su, L. Intermediate filaments in oral neoplasia. I. Oral cancer and epithelial dysplasia. Eur. J. Cancer, 30: 160-166, 1994.
29. Kuruc, N., Leube, R. E., Moll, I., Bader, B. L., and Franke, W. W. Synthesis of cytokeratin 13, a component characteristic of internal stratified epithelia, is not induced in human epidermal tumors. Differentiation, 42: 111-123, 1989.
30. Vaidya, M. M., Borges, A. M., Pradhan, S. A., Rajpal, R. M., and Bhisey, A. N. Altered keratin expression in buccal mucosal squamous cell carcinoma. J. Oral Pathol. Med., 18: 282-286, 1989.
31. Boisnic, S., Ouhayoun, J-P., Branchet, M. C., Frances, C., Béranger, J. Y., Le Chapentier, Y., and Szpirglas, H. Alteration of cytokeratin expression in oral lichen planus. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 79: 207-215, 1995.
32. Suo, Z., Holm, R., and Nesland, J. M. Squamous cell carcinomas. An immunohistochemical study of cytokeratins and involucrin in primary and metastatic tumors. Histopathology (Oxf.), 23: 45-54, 1993.
33. Hakomori, S. Tumor-associated carbohydrate antigens. Annu. Rev. Immunol., 2: 103-126, 1984.
34. Stubbe-Teglbjærg, C., Norrild, B., and Dabelsteen, E. Changes of blood group antigens in premalignant and malignant lesions of human exocervix. Acta Pathol. Microbiol. Immunol. Scand. Sect. A, 93: 149-151, 1985.