A case of spurious hypercalcitoninemia: A cautionary tale on the use of plasma calcitonin assays in the screening of patients with thyroid nodules for neoplasia

Journal of Endocrinological Investigation

Volumn 24, Issue 5, 2001, Pages 361-369

  Uwaifo, G I ^a   Remaley, A T ^b   Stene, M ^c   Reynolds, J C ^e   Yen, P M ^g   Snider, R H ^f   Becker, K L ^f   Sarlis, N J ^g  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b Microbiology Service   (United States)

^c Esoterix Endocrinology   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

^f and Kidney Diseases ^*

^g NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

C cell hyperplasia; Calcitonin; Hashimoto's thyroiditis; Immunoassay; Medullary thyroid carcinoma

Indexed keywords

CALCITONIN; LEVOTHYROXINE;

ADOLESCENT; ARTICLE; ASSAY; CALCITONIN BLOOD LEVEL; CASE REPORT; CLINICAL FEATURE; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; FEMALE; GOITER; HASHIMOTO DISEASE; HUMAN; HYPERCALCITONINEMIA; MASS SCREENING; METABOLIC DISORDER; THYROID MEDULLARY CARCINOMA; THYROID NODULE; THYROIDECTOMY; VALIDATION PROCESS;

ADOLESCENT; ANTIBODIES, ANTI-IDIOTYPIC; BIOPSY, NEEDLE; CALCITONIN; CARCINOMA, MEDULLARY; CHEMILUMINESCENT MEASUREMENTS; FALSE POSITIVE REACTIONS; FEMALE; HUMANS; IMMUNOASSAY; MAGNETIC RESONANCE IMAGING; MULTIPLE ENDOCRINE NEOPLASIA TYPE 2A; RADIOIMMUNOASSAY; THYROID NEOPLASMS; THYROID NODULE; THYROIDITIS, AUTOIMMUNE; TOMOGRAPHY, X-RAY COMPUTED; ULTRASONOGRAPHY;

EID: 0035009788     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03343874     Document Type: Article

References (58)

1. Thyroid masses: Approach to diagnosis and management in childhood and adolescence
2. Medullary carcinoma of the thyroid in Norway. Clinical course and endocrinological aspects
3. Medullary thyroid cancer
4. Medullary thyroid carcinoma
5. Medullary carcinoma of the thyroid. A study of the clinical features and prognostic factors in 161 patients
6. Surgery for benign and malignant diseases of the thyroid gland in childhood
7. Multiple endocrine neoplasia type 2: Management of patients and subjects at risk. French Study Group on Calcitonin-Secreting Tumors (GETC)
8. Medullary thyroid carcinoma: Genetic advances, treatment recommendations, and the approach to the patient with persistent hypercalcitoninemia
9. Familial medullary thyroid carcinoma: Presymptomatic diagnosis and management in children
10. Routine calcitonin determination in thyroid nodules - An effective approach?
11. Routine measurement of plasma calcitonin in nodular thyroid diseases
12. Interest of routine measurement of serum calcitonin: Study in a large series of thyroidectomized patients. The French Medullary Study Group
13. Influence of needle biopsy on management of thyroid nodules: Reasons to expand its use
14. Immunocytochemistry of the thyroid in surgical and cytologic specimens
15. Controversies in the management of cold, hot, and occult thyroid nodules
16. Prevalence of sporadic medullary thyroid carcinoma: The importance of routine measurement of serum calcitonin in the diagnostic evaluation of thyroid nodules
17. Should serum calcitonin be measured routinely in all patients with nodular thyroid disease?
18. Routine measurement of serum calcitonin in nodular thyroid diseases allows the preoperative diagnosis of unsuspected sporadic medullary thyroid carcinoma
19. Human calcitonin assay
20. Specificity of somatostatin receptor scintigraphy: A prospective study and effects of false-positive localizations on management in patients with gastrinomas
21. Plasma metanephrines in the diagnosis of pheochromocytoma
22. The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis
23. Estimates of circulating monomeric calcitonin: Studies in normal and thyroidectomized man
24. Procalcitonin and its component peptides in systemic inflammation: Immunochemical characterization
25. Pneumonitis-associated hyperprocalcitoninemia
26. Influence of smoking and snuff use on electrolytes, adrenal and calcium regulating hormones
27. Radioimmunoassay of calcitonin in normal human urine
28. Antibodies as a source of analytical errors
29. On the presence of autoantibodies in the plasma of patients suffering from medullary carcinoma of the thyroid
30. Highly sensitive calcitonin assay on the Nichols Advantage™ Specialty Analyzer
31. "Nonspecific" increases in plasma immunoreactive calcitonin in healthy individuals: Discrimination from medullary thyroid carcinoma by a new extraction technique
32. Clinical usefulness of a new chemiluminescent two-site immunoassay for human calcitonin
33. Serum calcitonin precursors in sepsis and systemic inflammation
34. Different efficacy of various blocking reagents to eliminate interferences by human anti-mouse antibodies with a two-site radioimmunoassay
35. Hypercalcitoninemia and inappropriate calciuria in the acute trauma patient
36. Serum calcitonin may be a marker for inhalation injury in burns
37. Differential diagnosis of hypercalcitoninemia
38. Hypercalcitoninemia in acutely ill children
39. Hypercalcitoninemia and hypocalcemia in acutely ill children: Studies in serum calcium, blood ionized calcium, and calcium-regulating hormones
40. Hypocalcemia and hypercalcitoninemia in critically ill children
41. Abnormal calcitonin basal levels and pentagastrin response in patients with chronic renal failure on maintenance hemodialysis
42. Hypercalcitoninemia, nodular goiter, and pancreatic tumor
43. Hypercalcitoninemia in conditions other than medullary cancers of the thyroid
44. The goitrous patient with an elevated serum calcitonin - What to do?
45. Medullary thyroid microcarcinoma: A clinicopathologic retrospective study of 38 patients with no prior familial disease
46. Nonparallel patterns of calcitonin and carcinoembryonic antigen levels in the follow-up of medullary thyroid carcinoma
47. Neuron-specific enolase and chromogranin A as markers of neuroendocrine tumours
48. Diagnostic relevance of the amino-terminal cleavage peptide of procalcitonin (PAS-57), calcitonin and calcitonin gene-related peptide in medullary thyroid carcinoma patients
49. Structural characterization of a high-molecular-mass form of calcitonin [procalcitonin-(60-116)-peptide] and its corresponding N-terminal flanking peptide [procalcitonin-(1-57)-peptide] in a human medullary thyroid carcinoma
50. Physiologic versus neoplastic C-cell hyperplasia of the thyroid: Separation of distinct histologic and biologic entities
51. Non-neoplastic hypercalcitoninemia. Pathological anatomy
52. C-cell hyperplasia associated with chronic lymphocytic thyroiditis: A retrospective quantitative study of 112 cases
53. Symptomatic C-cell hyperplasia associated with chronic lymphocytic thyroiditis
54. C-cell hyperplasia of the thyroid in a patient with goitrous hypothyroidism and Hashimoto's thyroiditis
55. Quantitative analysis of C cells in Hashimoto's thyroiditis
56. The effect of radioactive iodine treatment on thyroid C cells
57. Parathormone and calcitonin secretion in endemic goiter
58. Hashimoto's thyroiditis with medullary carcinoma