Specific immunoglobulin E responses in ZAP-70-deficient patients are mediated by Syk-dependent T-cell receptor signalling

Immunology

Volumn 103, Issue 2, 2001, Pages 164-171

  Toyabe, Shin Ichi ^a   Watanabe, Akihiro ^a   Harada, Waka ^a   Karasawa, Tamaki ^a   Uchiyama, Makoto ^a  

^a NIIGATA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN GP 39; IMMUNOGLOBULIN; IMMUNOGLOBULIN E; INTERLEUKIN 4; PICEATANNOL; PROTEIN KINASE; T LYMPHOCYTE RECEPTOR;

ARTICLE; B LYMPHOCYTE; CASE REPORT; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN T CELL LEUKEMIA VIRUS 1; INFANT; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; MONONUCLEAR CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; VIRUS CELL TRANSFORMATION;

ALLERGENS; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; ENZYME PRECURSORS; FEMALE; FOOD; HUMANS; IMMUNOGLOBULIN E; INFANT; INTERLEUKIN-4; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; SEVERE COMBINED IMMUNODEFICIENCY; SIGNAL TRANSDUCTION; TYROSINE; ZAP-70 PROTEIN-TYROSINE KINASE;

EID: 0035007575     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2001.01246.x     Document Type: Article

References (41)

1. Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase
2. + thymic selection in humans lacking zap-70 kinase
3. ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency
4. + T cells due to ZAP-70 deficiency
5. Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes
6. + T lymphocyte deficiency and impaired lymphocyte activation
7. + cells in human thymic medulla results in selective immune deficiency
8. CD40 and IgE: Synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells
9. + T cell clones and IL-4 induce IgG4 and IgE switching in purified human B cells via different signaling pathways
10. Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion
11. Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures
12. Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production
13. Role of interleukin-4 and interleukin-13 in synthesis of IgE and expression of CD23 by human B cells
14. Piceatannol (3,4,3′,5′-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor
15. Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities
16. Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA
17. Abnormal CD40-mediated activation pathway in B lymphocytes from patients with hyper-IgM syndrome and normal CD40 ligand expression
18. Microplate method for retrovirus-induced transformation of normal human T cells
19. Allergenic properties of ovomucoid in man
20. Allergenic epitopes of ovalbumin (OVA) in patients with hen's egg allergy: Inhibition of basophil histamine release by haptenic ovalbumin peptide
21. Cross-linking Fc receptors stimulate splenic non-B, non-T cells to secrete interleukin 4 and other lymphokines
22. + bone marrow and splenic non-B, non-T cells are highly enriched in the capacity to produce IL-4 in response to immobilized IgE, IgG2a, or ionomycin
23. + cells
24. Induction of human IgE synthesis in B cells by mast cells and basophils
25. CD40 ligand is functionally expressed on human eosinophils
26. Phenotype and function of engrafted maternal T cells in patients with severe combined immunodeficiency
27. XX T cells and XY B cells in two patients with severe combined immune deficiency
28. Identification by HLA typing of intrauterine-derived maternal T cells in four patients with severe combined immunodeficiency
29. Evaluation of 13 short tandem repeat loci for use in personal identification applications
30. Altered peptide ligand-induced partial T cell activation: Molecular mechanisms and role in T cell biology
31. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand
32. Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling
33. Response of a human T cell clone to a large panel of altered peptide ligands carrying single residue substitutions in an antigenic peptide: Characterization and frequencies of TCR agonism and TCR antagonista with or without partial activation
34. Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells
35. Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation
36. Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling
37. The Syk family of protein tyrosine kinases in T-cell activation and development
38. -/- mice by the Syk protein tyrosine kinase
39. Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function
40. Alternative TCR signaling in T cells derived from ZAP-70-deficient patients expressing high levels of Syk
41. + T cells in peripheral blood and their skin infiltration in CD8 deficiency