Use of psychoactive agents in the treatment of sexual dysfunction

CNS Drugs

Volumn 6, Issue 3, 1996, Pages 204-216

  Waldinger, Marcel D ^a  

^a LEYENBURG HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; AMFEBUTAMONE; ANTIDEPRESSANT AGENT; APOMORPHINE; BETHANECHOL; BUSPIRONE; CLOMIPRAMINE; CYPROHEPTADINE; DEXAMPHETAMINE; NALTREXONE; PEMOLINE; PHENTOLAMINE; SEROTONIN UPTAKE INHIBITOR; TRAZODONE; YOHIMBINE;

ANXIETY NEUROSIS; FEMALE; HEADACHE; HUMAN; MALE; NAUSEA; ORAL DRUG ADMINISTRATION; PRIAPISM; PRIORITY JOURNAL; PSYCHOTHERAPY; REVIEW; SEDATION; SEXUAL DYSFUNCTION; SUBCUTANEOUS DRUG ADMINISTRATION; TACHYCARDIA; VERTIGO;

EID: 0029838384     PISSN: 11727047     EISSN: None     Source Type: Journal    
DOI: 10.2165/00023210-199606030-00004     Document Type: Review

References (86)

1. Buffum J. Pharmacosexology: the effects of drugs on sexual function: a review. J Psychoactive Drugs 1982; 14: 5-44
2. Perryman RL, Thorner MO. The effects of hyperprolactinemia on sexual and reproductive function in men. J Androl 1981; 5: 233-42
3. Wein AJ, Van Arsdalen KN. Drug-induced male sexual function. Impotence 1988; 15: 23-31
4. Riley AJ. Prolactin and female sexual function. Br J Sex Med 1984; 11: 14-7
5. Gessa GL, Tagliamonte A. Possible role of brain serotonin and dopamine in controlling male sexual behavior. Adv Biochem Psychopharmacol 1974; 11: 217-27
6. Hyppa MT, Rinne VK, Sonninen V. The activating effect of L-dopa treatment on sexual function and its experimental background. Acta Neurol Scand 1970; 43 Suppl. 43: 232-4
7. Sobrinho LG, Sa-Melo P, Nunes MCP, et al. Sexual dysfunction of hyperprolactinaemic women, effects of bromocriptine. J Psychosom Obstet Gynaecol 1987; 6: 43-8
8. 1C receptors in drug-induced penile erections in rats. Psychopharmacology 1990; 101: 57-61
9. Segraves RT. Effects of psychotropic drugs on human erection and ejaculation. Arch Gen Psychiatry 1989; 46: 275-84
10. Ahlenius S, Larsson K, Svensson L, et al. Effects of a new type of 5-HT receptor agonist on male rat sexual behavior. Pharmacol Biochem Behav 1981; 15: 785-92
11. Rodriguez M, Castro R, Hernandez G, et al. Different roles of catecholaminergic and serotonergic neurons of the medial forebrain on male rat sexual behavior. Physiol Behav 1984; 33: 5-11
12. MacLean PD. Brain mechanisms of primal sexual functions and related behavior. In: Sandler M, Gessa GL, editors. Sexual behavior: pharmacology and biochemistry. New York: Raven Press, 1975: 1-11
13. Marson L, McKenna KE. The identification of a brainstem site controlling spinal sexual reflexes in male rats. Brain Res 1990; 515: 303-8
14. Levin RJ. The physiology of sexual function in women. Clin Obstet Gynecol 1980; 7: 213-52
15. Ogawa S, Kudo S, Kitsunai Y, et al. Increase in oxytocin secretion at ejaculation in male. Clin Endocrinol 1980; 13: 95-7
16. Murphy MR, Checkley SA, Seckl JR, et al. Naloxone inhibits oxytocin release at orgasm in man. J Clin Endocrinol Metab 1990; 71: 1056-8
17. Gartrell N. Increased libido in women receiving trazodone. Am J Psychiatry 1986; 143: 781-2
18. Sullivan G. Increased libido in three men treated with trazodone. J Clin Psychiatry 1988; 49: 202-3
19. Consensus development conference statement. National Institute of Health: impotence. Int J Impot Res 1993; 5: 181-99
20. Montorsi F, Guazzoni G, Rigatti P, et al. Pharmacological management of erectile dysfunction. Drugs 1995; 50: 465-79
21. Yohimbine: time for resurrection? [editorial]. Lancet 1986; II: 1194-5
22. Reid K, Morales A, Harris C, et al. Double-blind trial of yohimbine in treatment of psychogenic impotence. Lancet 1987 Aug 22; II: 421-3
23. Reid K, Surridge DH, Morales A, et al. Is yohimbine effective in the treatment of organic impotence? Results of a controlled trial. J Urol 1987; 137: 1168-72
24. Riley AJ, Riley EJ. Pharmacotherapy for sexual dysfunction: current status. In: Riley AJ, Peet M, Wilson C, editors. Sexual pharmacology. Oxford: Oxford Medical Publications, 1993: 211-35
25. Riley AJ, Goodman RE, Kellett JM, et al. Double blind trial of yohimbine hydrochloride in the treatment of erection inadequacy. Sex Marit Ther 1989; 4: 17-26
26. Susset JG, Tessier CD, Wincze J, et al. Effect of yohimbine hydrochloride on erectile impotence: a double-blind study. J Urol 1989; 141: 1360-3
27. Rosen RC, Ashton AK. Prosexual drugs: empirical status of the 'new aphrodisiacs'. Arch Sex Behav 1993; 22: 521-43
28. Saenz de Tajada I, Ware JC, Blanco R, et al. Pathophysiology of prolonged penile erection associated with trazodone use. J Urol 1991; 145: 60-4
29. Raymond L, Albo M, Costabile RA. Oral trazodone as empirical therapy for erectile dysfunction: a retrospective review. Urology 1995; 46: 117-20
30. Montorsi F, Strambi LF, Guazzoni G, et al. Effect of yohimbine-trazodone on psychogenic impotence: a randomized, double-blind, placebo-controlled study. Urology 1994; 44: 732-6
31. Scher M, Krieger JN, Juergens S. Trazodone and priapism. Am J Psychiatry 1983; 140: 1362-3
32. Thompson Jr JW, Ware MR, Blashfield RK. Psychotropic medication and priapism: a comprehensive review. J Clin Psychiatry 1990; 51: 430-3
33. Lal S, Ackman D, Thavundayil JX, et al. Effect of apomorphine, a dopamine receptor agonist, on penile tumescence in normal subjects. Prog Neuropsychopharmacol Biol Psychiatry 1984; 8: 695-9
34. Danjou P, Alexandre L, Warot D, et al. Assessment of erectogenic properties of apomorphine and yohimbine in man. Br J Clin Pharmacol 1988; 26: 733-9
35. Segraves RT, Bari M, Segraves K, et al. Effect of apomorphine on penile tumescence in men with psychogenic impotence. J Urol 1991; 145: 1174-5
36. Pellegrini-Quarantotti B, Borda M, Paglietti E, et al. Inhibition of copulatory behavior in male rat by D-Ala-Met-enkephalinamide. Life Sci 1978; 23: 673-8
37. Gessa GL, Paglietti E, Pellegrini-Quarantotti B. Induction of copulatory behavior in sexually inactive rats by naloxone. Science 1979; 204: 203-5
38. Fabbri A, Jannini EA, Gnessi L, et al. Endorphins in male impotence: evidence for naltrexone stimulation of erectile activity in patient therapy. Psychoneuroendocrinology 1989; 14: 103-11
39. Gwinup G. Oral phentolamine in nonspecific erectile insufficiency. Ann Intern Med 1988; 109: 162-3
40. Hellstrom WJG, Monga M, Wang R, et al. Penile erection in the primate: induction with nitric-oxide donors. J Urol 1994; 151: 1723-7
41. St Lawrence JS, Madakasira S. Evaluation and treatment of premature ejaculation: a critical review. Int J Psychiatry Med 1992; 22: 77-97
42. Frank E, Anderson C, Rubinstein D. Frequency of sexual dysfunction in 'normal' couples. N Engl J Med 1978; 299: 111-5
43. Goodman RE. An assessment of clomipramine (Anafranil) in the treatment of premature ejaculation. J Int Med Res 1980; 8 Suppl. 3: 53-9
44. Girgis SM, El-Haggar S, El-Hermouzy S. A double-blind trial of clomipramine in premature ejaculation. Andrologia 1982; 14: 364-8
45. Segraves RT, Saran A, Segraves K, et al. Clomipramine versus placebo in the treatment of premature ejaculation: a pilot study. J Sex Marital Ther 1993; 19: 198-200
46. Althof SE, Levine SB, Corty EW, et al. A double-blind crossover trial of clomipramine for rapid ejaculation in 15 couples. J Clin Psychiatry 1995; 56: 402-7
47. Waldinger MD, Hengeveld MW, Zwinderman AH. Paroxetine treatment of premature ejaculation: a double-blind, randomized, placebo-controlled study. Am J Psychiatry 1994; 151: 1377-9
48. Mendels J, Camera A, Sikes C. Sertraline treatment for premature ejaculation. J Clin Psychopharmacol 1995; 15: 341-6
49. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: American Psychiatric Association, 1994
50. Segraves RT. Sexual dysfunction complicating the treatment of depression. J Clin Psychiatry 1992; 10: 75-9
51. Balon R, Yeragani VK, Pohl R. Sexual dysfunction during antidepressant treatment. J Clin Psychiatry 1993; 54: 209-12
52. Smith JM. Abuse of the antiparkinson drugs: a review of the literature. J Clin Psychiatry 1980; 41: 351-4
53. Wilson CA. Pharmacological targets for the control of male and female sexual behaviour. In: Riley AJ, Peet M, Wilson C, editors. Sexual pharmacology. Oxford: Oxford Medical Publications, 1993: 1-58
54. Gorzalka BB, Mendelson SD, Watson NV. Serotonin receptor subtypes and sexual behavior. Ann NY Acad Sci 1990; 600: 435-46
55. Berendsen HHG, Broekkamp CLE. Behavioural evidence for functional interactions between 5-HT-receptor subtypes in rats and mice. Br J Pharmacol 1990; 101: 667-73
56. Rothschild AJ. Selective serotonin reuptake inhibitor-induced sexual dysfunction: efficacy of a drug holiday. Am J Psychiatry 1995; 152: 1514-6
57. Feder R. Reversal of antidepressant activity of fluoxetine by cyproheptadine in three patients. J Clin Psychiatry 1991; 52: 163-4
58. DeCastro R. Reversal of MAOI-induced anorgasmia with cyproheptadine [letter]. Am J Psychiatry 1985; 142: 783
59. McCormick S, Olin J, Brotman AW. Reversal of fluoxetine-induced anorgasmia by cyproheptadine in two patients. J Clin Psychiatry 1990; 51: 383-4
60. Arnoth S, Nutt D. Successful treatment of fluvoxamine-induced anorgasmia by cyproheptadine. Br J Psychiatry 1994; 164: 838-9
61. Sovner R. Anorgasmia associated with imipramine but not desipramine: case report. J Clin Psychiatry 1983; 44: 345-6
62. Sovner R. Treatment of tricyclic antidepressant-induced orgasmic inhibition with cyproheptadine [letter]. J Clin Psychopharmacol 1984; 4: 169
63. Steele TE, Howell EF. Cyproheptadine for imipramine-induced anorgasmia [letter]. J Clin Psychopharmacol 1986; 6: 326-7
64. Aizenberg D, Zemishlany Z, Weizman A. Cyproheptadine treatment of sexual dysfunction induced by serotonin reuptake inhibitors. Clin Neuropharmacol 1995; 18: 320-4
65. Cohen AJ. Fluoxetine-induced yawning and anorgasmia reversed by cyproheptadine treatment [letter]. J Clin Psychiatry 1992; 53: 174
66. Yager J. Bethanechol chloride can reverse erectile and ejaculatory dysfunction induced by tricyclic antidepressants and mazindol: case report. J Clin Psychiatry 1986; 47: 210-1
67. Segraves RT. Reversal by bethanechol of imipramine-induced ejaculatory dysfunction [letter]. Am J Psychiatry 1987; 144: 1243-4
68. Gross M. Reversal of sexual dysfunction by antidepressants. Am J Psychiatry 1982; 139: 1193-4
69. Price J, Grunhaus LJ. Treatment of clomipramine-induced anorgasmia with yohimbine: a case report. J Clin Psychiatry 1990; 51: 32-3
70. Hollander E, McCarley A. Yohimbine treatment of sexual side effects induced by serotonin reuptake blockers. J Clin Psychiatry 1992; 53: 207-9
71. Jacobsen FM. Fluoxetine-induced sexual dysfunction and an open trial of yohimbine. J Clin Psychiatry 1992; 53: 119-22
72. Beraldi M, Bertolini A. Penile erections induced by amantadine in male rats. Life Sci 1974; 14: 1231-5
73. Sachs B, Meisel R. The physiology of male sexual behavior. In: Knobil E, Neill J, editors. The physiology of reproduction. New York: Raven Press, 1988: 1432-5
74. Balogh S, Hendricks SE, Kang J. Treatment of fluoxetine-induced anorgasmia with amantadine [letter]. J Clin Psychiatry 1992; 53: 212-3
75. Masand PS, Reddy N, Gregory R. SSRI-induced sexual dysfunction successfully treated with amantadine. Depression 1995; 2: 319-21
76. Shrivastava RK, Shrivastava S, Overweg N, et al. Amantadine in the treatment of sexual dysfunction associated with selective serotonin reuptake inhibitors [letter]. J Clin Psychopharmacol 1995; 15: 83-4
77. Gardner EA, Johnson JA. Bupropion: an antidepressant without sexual pathophysiological action. J Clin Psychopharmacol 1985; 5: 24-9
78. Walker PW, Cole JO, Gardner EA, et al. Improvement in fluoxetine-associated sexual dysfunction in patients switched to bupropion. J Clin Psychiatry 1993; 54: 459-65
79. Ascher JA, Cole JO, Colin JN, et al. Bupropion: a review of its mechanism of antidepressant activity. J Clin Psychiatry 1995; 56: 395-401
80. Labbate LA, Pollack MH. Treatment of fluoxetine-induced sexual dysfunction with bupropion: a case report. Ann Clin Psychiatry 1994; 6: 13-5
81. Norden MJ. Buspirone treatment of sexual dysfunction associated with selective serotonin re-uptake inhibitors. Depression 1994; 2: 109-12
82. Jacobsen FM. Possible augmentation of antidepressant response by buspirone. J Clin Psychiatry 1991; 525: 217-20
83. Bakish D. Fluoxetine potentiation by buspirone: three case histories. Can J Psychiatry 1991; 36: 749-50
84. Joffe RT, Schuller DR. An open study of buspirone augmentation of serotonin reuptake inhibitors in refractory depression. J Clin Psychiatry 1993; 54: 269-71
85. Gitlin MJ. Treatment of sexual side effects with dopaminergic agents [letter]. J Clin Psychiatry 1995; 56: 124
86. Harrison WM, Rabkin JG, Ehrhardt AA, et al. Effects of antidepressant medication on sexual function: a controlled study. J Clin Psychopharmacol 1986; 6: 144-9