A microsatellite polymorphism in the gamma interferon gene is associated with resistance to gastrointestinal nematodes in a naturally-parasitized population of Soay sheep

Parasitology

Volumn 122, Issue 5, 2001, Pages 571-582

  Coltman, D W ^a,d   Wilson, K ^b   Pilkington, J G ^a   Stear, M J ^c   Pemberton, J M ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF STIRLING   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Cytokine; Helminth; Immunity; Ovis aries; Parasite

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN A; MICROSATELLITE DNA;

ANIMAL EXPERIMENT; ARTICLE; FECES ANALYSIS; FEMALE; GENE LOCUS; GENETIC POLYMORPHISM; HELMINTH; IMMUNE RESPONSE; INFECTION RESISTANCE; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SHEEP;

ANIMALS; FEMALE; GASTROINTESTINAL DISEASES; IMMUNITY, NATURAL; IMMUNOGLOBULIN A; INTERFERON TYPE II; MALE; MICROSATELLITE REPEATS; NEMATODE INFECTIONS; QUANTITATIVE TRAIT, HERITABLE; SHEEP; SHEEP DISEASES;

ANIMALIA; NEMATODA; OVIS ARIES; TELADORSAGIA CIRCUMCINCTA; VERMES;

EID: 0035003126     PISSN: 00311820     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0031182001007570     Document Type: Article

References (52)

1. Transmission-disequilibrium tests for quantitative traits
2. Extensive protein and microsatellite variability in an isolated, cyclic ungulate population
3. Prospects for development of genetic markers for resistance to gastrointestinal parasite infection in sheep
4. Genetic parameters for faecal egg count following mixed, natural, predominantly Ostertagia circumcincta infection and relationships with live weight in young lambs
5. Persistent instability and population regulation in Soay sheep
6. Early development and population fluctuations in Soay sheep
7. Male reproductive success in a promiscuous mammal: Behavioural estimates compared with genetic paternity
8. Parasite-mediated selection against inbred Soay sheep in a free-living, island population
9. Finding disease resistance QTL in sheep
10. A second-generation linkage map of the sheep genome
11. Intestinal nematode parasites, cytokines and effector mechanisms
12. Cytokine-mediated regulation of chronic intestinal helminth infection
13. Development of an assay to measure in vivo cytokine production in the mouse
14. Mapping of the interferon gamma gene (IFNG) to chromomes 3 in sheep and 5 in goat by FISH
15. Th2-mediated host protective immunity to intestinal nematode infections
16. Overcompensation and population cycle in an ungulate
17. Noise and determinism in synchronized sheep dynamics
18. The role of nematode parasites in Soay sheep (Ovis aries L.) mortality during a population crash
19. Parasite-associated polymorphism in a cyclic ungulate population
20. Epidemiology of nematode infections of Soay sheep (Ovis aries L.) on St Kilda
21. Selection for foraging efficiency during a population crash in Soay sheep
22. Early cytokine responses during intestinal parasitic infections
23. Major histocompatibility complex variation associated with juvenile survival and parasite resistance in a large unmanaged ungulate population (Ovis aries L.)
24. Molecular analysis of a promiscuous, fluctuating mating system
25. Ovine microsatellites at the OarVH34, OarVH41, OarVH58, OarVH61 and OarVH72 loci
26. Anthelmintic resistance
27. Relationship between immunological responsiveness controlled by T-helper 2 lymphocytes and infections with parasitic helminths
28. A transmission disequilibrium test for quantitative trait loci
29. Genepop (Version-1.2)-Population-genetics software for exact tests and ecumenicism
30. Group report: Genetics and evolution of infectious diseases in natural populations
31. Analyzing tables of statistical tests
32. The role of drugs in the control of parasitic nematode infections: Must we do without?
33. A diallelic tetranucleotide repeat, (GT(3))(5 or 6), within intron 1 of the ovine interferon-gamma gene
34. An ovine major histocompatibility complex Drb1 allele is associated with low fecal egg counts following natural, predominantly Ostertagia circumcincta infection
35. Local and plasma antibody responses to the parasitic larval stages of the abomasal nematode Ostertagia circumcincta
36. Heritable variation in resistance to gastro-intestinal nematodes in an unmanaged mammal population
37. Anchoring of bovine chromosomes 4, 6, 7, 10, and 14 linkage group telomeric ends via FISH analysis of lambda clones
38. How hosts control worms
39. Regulation of egg production, worm burden, worm length and worm fecundity by host responses in sheep infected with Ostertagia circumcincta
40. The key components of resistance to Ostertagia circumcincta in lambs
41. How lambs control infection with Ostertagia circumcincta
42. Mechanisms underlying resistance to nematode infection
43. Fluctuating trade-offs favour precocial maturity in male Soay sheep
44. The temporal relationship among anti-parasite immune elements expressed during the early phase of infection of the rat with Trichinella spiralis
45. Inferences about linkage disequilibrium
46. Generalized linear modelling for parasitologists
47. Analysis of aggregated parasite distributions: A comparison of methods
48. Prospects of breeding small ruminants for resistance to internal parasites