Th2-mediated host protective immunity to intestinal nematode infections

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 352, Issue 1359, 1997, Pages 1377-1384

  Grencis, R K ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0031590303     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.1997.0123     Document Type: Article

References (71)

1. Ahmad, A., Wang, C. H. & Bell, R. G. 1984 A role for IgE in intestinal immunity: Expression of rapid expulsion of Trichinella spiralis from rats transfused with IgE and thoracic duct lymphocytes. J. Immunol. 70(146), 767-3563.
2. v mice. J. Parasitol. 70, 767-771.
3. Bancroft, A. J., Else, K. J., Sypek, J. P. & Grencis, R. K. 1997 IL-12 promotes a chronic intestinal nematode infection. Eur. J. Imunol. 27, 866-870.
4. Behnke, J. M., Barnard, C. J. & Wakelin, D. 1992 Understanding chronic nematode infections: evolutionary considerations, current hypotheses and the way forward. J. Parasitol. 22, 861-907.
5. Behnke, J. M., Wahid, F. N., Grencis, R. K., Else, K. J., Ben-Smith, A. & Goyal, P. K. 1993 Immunological relationships during primary infection with Heligmosomoides polygyrus (Nematospiroides dubius): down regulation of specific cytokine secretion (IL-9 and IL-10) correlates with poor mastocytosis and chronic survival of adult worms. Parasite Immunol. 15, 415-421.
6. Chan, M. S., Medley, G. F., Jaimson, D. & Bundy, D. A. P. 1994 The evaluation of potential global morbidity attributable to intestinal nematode infections. Parasitology 109, 373-387.
7. Coffman, R. L., Seymour, B. W. P., Hadak, S., Jackson, J. & Rennick, D. 1989 Antibody to interleukin 5 inhibits helminth induced eosinophilia in mice. Science 245, 308-310.
8. v anaemic mice. Infect. Immun. 33, 54-58.
9. Dehlawi, M. S.,Wakelin, D. & Behnke, J. M. 1987 Suppression of mucosal mastocytosis by infection with the intestinal nematode Nematospiroides dubius. Parasite Immunol. 12, 561-566.
10. Donaldson, L. E., Schmitt, E., Huntley, J. F., Newlands, G. F. J. & Grencis, R. K. 1996 A critical role for stem cell factor and c-kit in host protective immunity to an intestinal helminth. Int. Immunol. 8, 559-567.
11. Else, K. J., Finkelman, F. D., Maliszewski, C. R. & Grencis, R. K. 1994 Cytokine mediated regulation of chronic intestinal helminth infection. J. Exp. Med. 179, 347-351.
12. Else, K. J. & Grencis, R. K. 1991 Cellular immune responses to the nematode parasite Trichuris muris. I. Differential cytokine production during acute or chronic infection. Immunology 72, 508-513.
13. Else, K. J. & Grencis, R. K. 1996 Antibody independent effector mechanisms in resistance to the intestinal nematode parasite Trichuris muris. Infect. Immun. 64, 2950-2954.
14. Else, K. J., Hühner, L. & Grencis, R. K. 1992 Cellular immune responses to the murine nematode parasite Trichuris muris. II. Differential induction of Th cell subsets in resistant versus susceptible mice. Immunology 75, 232-237.
15. Faulkner, H. C., Humphreys, N., Renauld, J. C., Van Snick, J. & Grencis, R.K. 1997 Interleukin-9 is involved in host protective immunity to intestinal nematode infection. Eur. J. Immunol. (In the press.)
16. Finkelman, F. D., Madden, K. B., Cheever, A. W., Katona, I. M., Morris, S. C., Gately, M. K., Hubbard, B. R., Gause, W. C. & Urban, J. F. Jr 1994 Effects of interleukin12 on immune responses and host protection in mice infected with intestinal nematode parasites. J. Exp. Med. 179, 1563-1572.
17. Finkelman, F. D., Shea-Donahue, T., Goldhill, J., Sullivan, C. A., Morris, S. C., Madden, K. B., Gause, W. C. & Urban, J.F. 1997 Cytokine regulation of host defence against parasit ic gastrointestinal nematodes: lessons from studies with rodent models. A. Rev. Immunol. 15, 505-534.
18. Galli, S. J., Geissler, E. N. & Zsebo, K. M. 1994 The kit ligand, stem cell factor. Adv. Immunol. 55, 1.
19. Garside, P., Grencis, R. K. & Mowat, A. McI. 1992 T lymphocyte dependent enteropathy in murine Trichinella spiralis infection. Parasite Immunol. 14, 217-225.
20. Ghildyal, N., McNeil, H. P., Gurish, M. F., Austen, K. F. & Stevens, R. L. 1992 Transcriptional regulation of the mucosal mast cell specific protease gene, MMCP-2, by interleukin 10 and interleukin3. J. Biol. Chem. 12, 8473-8477.
21. Gordon, J. R., Burd, P. R. & Galli, S. J. 1990 Mast cells as a source of multifunctional cytokines. Immunol. Today 11, 458-464.
22. Grencis, R. K., Hültner, L. & Else, K. J. 1991 Host protective immunity to Trichinella spiralis in mice: activation of Th cell subsets and lymphokine secretion in mice expressing different response phenotypes. Immunology 74, 329-332.
23. Grencis, R .K., Reidlinger, J. & Wakelin, D. 1985 L3T4 positive lymphoblasts are responsible for transfer of immunity to Trichinella spiralis in mice. Immunology 56, 213-218.
24. Herndon, F. J. & Kayes, S. G. 1992 Depletion of eosinophils by anti-IL-5 monoclonal antibody treatment of mice infected with Trichinella spiralis does not alter parasite burden or immunologic resistance to re-infection. J. Immunol. 149, 3642-3647.
25. - secretion and parasite rejection in rat intestine. J. Immunol. 138, 1250-1255.
26. Horri, Y, Khan, A. I. & Nawa, Y 1993 Persistent infection with Strongyloides venezuelensis and normal expulsion of Nippostrongylus brasiliensis in mongolian gerbils, Meriones unguliculatus, with reference to the cellular responses in the intestinal mucosa. Parasite Immunol. 15, 175-179.
27. Hühner, L., Druez, C., Moeller, J., Uyutenhove, C., Schmitt, E., Rüde, E., Dörmer, P. & Van Snick, J. 1990 Mast cell growth-enhancing activity (MEA) is structurally related and functionally identical to the novel mouse T cell growth factor P40/TCGF III (interleukin 9). Eur. J. Immunol. 20, 1413-1416.
28. Ishikawa, N., Horii, Y. & Nawa, Y 1993 Immune mediated alteration of the terminal sugars of goblet cell mucins in the small intestine of Nippostrongylus brasiliensis infected rats. Immunology 78, 303-307.
29. Jacobson, R. H., Reed, N. D. & Manning, D. D. 1977 Expulsion of Nippostrongylus brasiliensis from mice lacking antibody production potential. Immunology 32, 867-874.
30. Jarrett, E. E. E. & Bazin, H. 1974 Elevation of total serum IgE in rats following helminth parasite infection. Nature 251, 613-615.
31. Katona, I. M., Urban, J. F. Jr & Finkelman, F. D. 1988 The role of L3T4+ and Ly2+ Tcells in the IgE response and immunity to Nippostrongylus brasiliensis. J. Immunol. 140, 3206-3211.
32. Keegan, A. D., Ryan, J. J. & Paul, W. E. 1996 IL-4 regulates growth and differentiation by distinct mechanisms. Immunologist 4, 194-198.
33. Khan, W. I., Abe, T., Ishikawa, N., Nawa,Y. & Yoshimura, K. 1995 Reduced amount of intestinal mucus treatment with anti-CD4 antibody intereferes with the spontaneous cure of Nippostrongylus brasiliensis infection in mice. Parasite Immunol. 17, 485-491.
34. Kopf, M., Le Gros, G., Bachmann, M., Lamers, M. C., Bleuthmann, H. & Kohler, G. 1993 Disruption of the murine IL-4 gene blocksTh2 cytokine response. Nature 362, 245-248.
35. Koyama, K., Tamanchi, H. & Ito, Y. 1995 The role of CD4+ and CD8+ T cells in protective immunity to the murine parasite Trichuris muris. Parasite Immunol. 17, 161-165.
36. Kühn, R., Rajewsky, K. & Müller, W. 1991 Generation and analysis of interleukin 4 deficient mice. Science 254, 707-710.
37. Lawrence, R. A., Gray, C. A., Osbourne, J. & Maizels, R. 1996 Nippostrongylus brasiliensis. Cytokine responses and nematode expulsion in normal and IL-4 deficient mice. Expl Parasitol. 84, 65-73.
38. Madden, K. B., Urban, J. F. Jr, Ziltner, H. J., Schrader, J. W., Finkelman, F. D. & Katona, I. M. 1991 Antibodies to IL-3 and IL-4 suppress helminth induuced intestinal mastocytosis. J. Immunol. 147, 1387-1394.
39. Maizels, R. M., Bundy, D. A. P., Selkirk, M. E., Smith, D. F. & Anderson, R. M. 1993 Immunological modulation and evasion by helminth parasites in human populations. Nature 365, 797-805.
40. Manson-Smith, D. F., Bruce, R. G. & Parrott, D. M. V. 1979 Villous atrophy and expulsion of intestinal Trichinella spiralis are mediated by T cells. Cell. Immunol. 47, 285-292.
41. Miller, H. R. P. 1987 Gastrointestinal mucus, a medium for survival and for elimination of parasitic nematodes and protozoa. Parasitolugy 94, S77-S100.
42. Miller, H. R. P. & Nawa, Y. 1979 Nippostrongylus brasiliensis: intestinal goblet cell response in adoptively immunized rats. Expl Parasitol. 47, 81-90.
43. Moqbel, R., Wakelin, D., MacDonald, A. J., King, S. J., Grencis, R. K. & Kay, A. B. 1987 Release of leukotrienes during rapid expulsion of Trichinella spiralis from immune rats. Immunology 60, 425-430.
44. Morawetz, R. A., Gabriele, L., Rizzo, L. V., Noben-Trauth, N., Kühn, R., Rajewsky, K., Müller, W., Doherty, T. M., Finkelman, F. D., Coffman, R. G. & Morse, H. C. III 1996 Interleukin (IL-) 4- independent immunoglobulin class switch to immunoglobulin (Ig) E in the mouse. J. Exp. Med. 184, 1651-1661.
45. Mosmann, T. R. & Coffman, R. L. 1989 Thl and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. A. Rev. Immunol. 7, 145-173.
46. Mosmann, T. R. & Subach, S. 1996 The expanding universes of Tcell subsets: Thl, Th2 and more. Immunol. Today 17, 139-146.
47. Mowat, A. M. 1989 Antibody to IFN-g prevents immunologically mediated damage in murine GVH reaction. Immunology 68, 18-23.
48. Murray, M. 1972 Immediate hypersensitivity effector mechanisms. II. In vivo reactions. In Immunity to animal parasites (ed. E. J. L. Soulsby), pp. 155-190. New York: Academic Press.
49. Nawa, Y, Ishikawa, N., Tsuchiya, K., Horii, Y, Abe, T., Khan, A. I., Shi, B., Itoh, H., Ide, H. & Uchiyama, F. 1994 Selective mechanisms for the expulsion of intestinal helminths. Parasite Immunol. 16, 333-338.
50. Ogilvie, B. M. & Jones, V. E. 1968 Passive protection with cells or antiserum against Nippostrongylus brasiliensis in the rat. Parasitology 58, 939-949.
51. Ogilvie, B. M. & Love, R. J. 1974 Co-operation between antibodies and cells in immunity to a nematode parasite. Transplantn Rev. 19, 147-168.
52. Perdue, M. H., Ramage, J. K., Bürget, D., Marshall, J. & Masson, S. 1989 Intestinal mucosal injury is associated with mast eel activation and leukotriene generation during Nippostrongylus brasiliensis induced inflammation in the rat. Digest. Dis. Sci. 34, 724-731.
53. Pritchard, D. I. 1993 Immunity to helminths. Is too much IgE parasite rather than host protective? Parasite Immunol. 15, 5-8.
54. Pritchard, D. I., Williams, D. J., Behnke, J. M. & Lee, T. D. G. 1983 The role of IgG1 hypergammaglobulinaemia in immunity to the gastrointestinal nematode Nematospiroides dubius. The immunochemical purification, antigen specificity and in vivo anti-parasite effect of IgG1 from immune scrum. Immunology 49, 353-365.
55. Puddington, L., Olson, S. & Lefrancois, L. 1994 Interactions between stem cell factor and c-kit are required for intestinal immune system homeostasis. Immunity 1, 733-740.
56. Ramaswamy, K., Goodman, R. E. & Bell, R. G. 1994 Cytokine profile of protective anti-Trichinella spiralis CD4+ Ox22+ and non-protective CD4+ Ox22+ thoracic duct cells in rats: secretion of 11-4 alone does not determine protective capacity. Parasite Immunol. 16, 435-445.
57. Ramaswamy, K., Jakami, J. & Bell, R. G. 1994 Evidence for an interleukin 4 inducible immunoglobulin E uptake and transport mechanism in the intestine. J. Exp. Med. 180, 1793-1803.
58. Rennick, D. M., Lee, F. D., Yokota, T., Arai, K., Cantor, H. & Nabel, G. J. 1985 A cloned MCGF cDNA encodes a multilineage hemopoetic growth factor: multiple activities of interleukin 3. J. Immunol. 134, 910-914.
59. Scudamore, C. L., Thornton, E. M., McMillan, L., Newlands, G.F.J. & Miller, H.R.P. 1995 Release of the mucosal mast cell granule chymase, rat mast cell protease II during anaphylaxis is associated with the rapid development of paracellular permeability to macromolecules in rat jejunum. J. Exp. Med. 182, 1871-1881.
60. Symons, L. E. A. 1965 Kinetics of epithelial cells and morphology of villi and crypts in the jejunum of the rat infected with Nippostrongylus brasiliensis. Gastroenterologe 49, 158-168.
61. Symons, L. E. A. 1978 Epithelial cell mitosis and morphology in worm free regions of the intestine of the rat infected with Nippostronglus brasiliensis. J. Parasitol. 64, 958-959.
62. Takai, T., Li, M., Sylvestre, D., Clynes, R. & Ravetch, J. V. 1994 FcRg Chain deletion results in pleiotrophic effector cell defects. Cell 76, 519-529.
63. Taliaferro, W. H. & Sarles, M. P. 1939 The cellular reactions in the skin, lungs and intestine of normal and immune rats after infection with Nippostrongylus brasiliensis. J. Infect. Dis. 64, 157-192.
64. Tuohy, M., Lammas, D. A., Wakelin, D., Huntley, J. F., Newlands, G. F. J. & Miller, H. R. P. 1990 Functional correlations between mucosal mast cell activity and immunity to Trichinella spiralis in high and low responder mice. Parasite Immunol. 12, 675-685.
65. Urban, J. F. Jr, Katona, I. M. & Finkelman, F. D. 1991a Heligmosomoides polygyrus: CD4+ but not CD8+ T cells regulate the IgE response and protective immunity in mice. Expl Parasitol. 75, 500-511.
66. Urban, J. F. Jr, Katona, I. M, Paul, W. E. & Finkelman, F. D. 1991b Interlcukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice. Proc. Natn. Acad. Sci. USA 88, 5513-5517.
67. Urban, J. F. Jr, Maliszewski, C. R., Madden, K. B., Katona, I. M. & Finkelman, F. D. 1995 IL-4 treatment can cure established gastrointestinal nematode infection in immunocompetent and immunodeficient mice. J. Immunol. 154, 4675-4680.
68. Wahid, F. N. & Behnke, J. M. 1993 Immunological relationships during primary infection with with Heligmosomoides polygyrus. Regulation of fast response phenotype by H-2 and non-H-2 genes. Parasitology 107, 343-350.
69. Wahid, F. N., Behnke, J. M., Grencis, R. K., Else, K. J. & Ben-Smith, A. W. 1994 Immunological relationships during primary infection with Heligmosomoides polygyrus: Th2 cytokines and primary response phenotype. Parasitology 108, 461-471.
70. Wakelin, D. 1978 Immunity to intestinal parasites. Nature 273, 617-620.
71. Woodbury, R. G., Miller, H. R. P., Huntley, J. F., Newlands, G. F. J., Palliser, A. C. & Wakclin, D. 1984 Mucosal mast cells are functionally active during the spontaneous expulsion of intestinal nemtode infections in the rat. Nature 312, 450-452.