Tumour necrosis factor-α (TNF-α) polymorphisms -857c/a and -863c/a are associated with tnf-α secretion from human adipose tissue

Diabetologia

Volumn 44, Issue 5, 2001, Pages 654-655

  Skoog, T ^a   Eriksson, P ^a   Hoffstedt, J ^a   Ryden M ^a   Hamsten, A ^a   Arner, P ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE TISSUE; ALLELE; CELL TYPE; DISEASE ASSOCIATION; GENETIC POLYMORPHISM; LETTER; MACROPHAGE; MONOCYTE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADIPOSE TISSUE; ADULT; ALLELES; BODY MASS INDEX; CHOLESTEROL; CHOLESTEROL, HDL; FEMALE; HUMANS; INSULIN; MALE; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035003016     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051673     Document Type: Letter

References (8)

1. A common functional polymorphism (C→A substitution at position -863) in the promoter region of the tumour necrosis factor-alpha (TNF-alpha) gene associated with reduced circulating levels of TNF-alpha
2. The -308 tumor necrosis factor-alpha promoter polymorphism effects transcription
3. Different transcriptional activity and in vitro TNF-alpha production in psoriasis patients carrying the TNF-alpha 238A promoter polymorphism
4. The TNF-alpha gene Nco I polymorphism influences the relationship among insulin resistance, percent body fat, and increased serum leptin levels
5. Polymorphisms of the tumour necrosis factor-alpha gene, coronary heart disease and obesity
6. Excessive fat accumulation is associated with the TNF alpha-308 G/A promoter polymorphism in women but not in men
7. Tumor necrosis factor-alpha-238 and -308 polymorphisms do not associate with traits related to obesity and insulin resistance
8. Secretion of tumor necrosis factor-alpha shows a strong relationship to insulin-stimulated glucose transport in human adipose tissue