Generating new ligand-binding RNAs by affinity maturation and disintegration of allosteric ribozymes

RNA

Volumn 7, Issue 4, 2001, Pages 524-536

  Soukup, Garrett A ^a,b   Derose, Elizabeth C ^a   Koizumi, Makoto ^a,c   Breaker, Ronald R ^a  

^a YALE UNIVERSITY   (United States)

^b CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DAIICHI SANKYO CO   (Japan)

Author keywords

Aptamer; Catalytic RNA; Effector; Hammerhead; In vitro selection; Molecular recognition

Indexed keywords

CYCLIC CMP; CYCLIC GMP; CYCLIC NUCLEOTIDE; RIBOZYME;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; CATALYSIS; HUMAN; LIGAND BINDING; MOLECULAR RECOGNITION; MUTAGENESIS; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE; RNA BINDING;

ALLOSTERIC REGULATION; BASE SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; CYCLIC AMP; CYCLIC CMP; CYCLIC GMP; DIRECTED MOLECULAR EVOLUTION; GENETIC ENGINEERING; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; NUCLEOTIDES, CYCLIC; RNA, CATALYTIC;

EID: 0035001974     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1355838201002175     Document Type: Article

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