In vitro activity of PR-39, a proline-arginine-rich peptide, against susceptible and multi-drug-resistant Mycobacterium tuberculosis

Journal of Antimicrobial Chemotherapy

Volumn 47, Issue 5, 2001, Pages 575-580

  Linde, Charlotte M A ^a,b   Hoffner, Sven E ^a   Refai, Essam ^b   Andersson, Mats ^b  

^a SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; POLYPEPTIDE ANTIBIOTIC AGENT; PR 39; PROLINE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIUM ISOLATE; COLONY FORMING UNIT; CONCENTRATION RESPONSE; CONTROLLED STUDY; GROWTH INHIBITION; IN VITRO STUDY; MULTIDRUG RESISTANCE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; RADIOMETRY;

EID: 0035001927     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/47.5.575     Document Type: Article

References (37)

1. Boman, H. G. (1995). Peptide antibiotics and their role in innate immunity. Annual Review of Immunology 13, 61-92.
2. Andreu, D. & Rivas, L. (1998). Animal antimicrobial peptides: an overview. Biopolymers 47, 415-33.
3. Agerberth, B., Lee, J. Y., Bergman, T., Carlquist, M., Boman, H. G., Mutt, V. et al. (1991). Amino acid sequence of PR-39. Isolation from pig intestine of a new member of the family of proline-arginine-rich antibacterial peptides. European Journal of Biochemistry 202, 849-54.
4. Vunnam, S., Juvvadi, P. & Merrifield, R. B. (1997). Synthesis and antibacterial action of cecropin and proline-arginine-rich peptides from pig intestine. Journal of Peptide Research 49, 59-66.
5. Shi, J., Ross, C. R., Chengappa, M. M., Sylte, M. J., McVey, D. S. & Blecha, F. (1996). Antibacterial activity of a synthetic peptide (PR-26) derived from PR-39, a proline-arginine-rich neutrophil antimicrobial peptide. Antimicrobial Agents and Chemotherapy 40, 115-21.
6. Cabiaux, V., Agerberth, B., Johansson, J., Homble, F., Goormaghtigh, E. & Ruysschaert, J. M. (1994). Secondary structure and membrane interaction of PR-39, a Pro+Arg-rich antibacterial peptide. European Journal of Biochemistry 224, 1019-27.
7. Boman, H. G., Agerberth, B. & Boman, A. (1993). Mechanisms of action on Escherichia coli of cecropin P1 and PR-39, two antibacterial peptides from pig intestine. Infection and Immunity 61, 2978-84.
8. Gallo, R. L., Ono, M., Povsic, T., Page, C., Eriksson, E., Klagsbrun, M. et al. (1994). Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds. Proceedings of the National Academy of Sciences, USA 91, 11035-9.
9. Shi, J., Ross, C. R., Leto, T. L. & Blecha, F. (1996). PR-39, a proline-rich antibacterial peptide that inhibits phagocyte NADPH oxidase activity by binding to Src homology 3 domains of p47 phox. Proceedings of the National Academy of Sciences, USA 93, 6014-8.
10. Huang, H. J., Ross, C. R. & Blecha, F. (1997). Chemoattractant properties of PR-39, a neutrophil antibacterial peptide. Journal of Leukocyte Biology 61, 624-9.
11. Miyakawa, Y., Ratnakar, P., Rao, A. G., Costello, M. L., Mathieu-Costello, O., Lehrer, R. I. et al. (1996). In vitro activity of the antimicrobial peptides human and rabbit defensins and porcine leukocyte protegrin against Mycobacterium tuberculosis. Infection and Immunity 64, 926-32.
12. Ogata, K., Linzer, B. A., Zuberi, R. I., Ganz, T., Lehrer, R. I. & Catanzaro, A. (1992). Activity of defensins from human neutrophilic granulocytes against Mycobacterium avium-Mycobacterium intracellulare. Infection and Immunity 60, 4720-5.
13. Sharma, S., Verma, I. & Khuller, G. K. (1999). Biochemical interaction of human neutrophil peptide-1 with Mycobacterium tuberculosis H37Ra. Archives of Microbiology 171, 338-42.
14. Lehrer, R. I., Barton, A., Daher, K. A., Harwig, S. S., Ganz, T. & Selsted, M. E. (1989). Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity. Journal of Clinical Investigation 84, 553-61.
15. Hoffner, S. E., Gezelius, L. & Olsson-Liljequist, B. (1997). In-vitro activity of fluorinated quinolones and macrolides against drug-resistant Mycobacterium tuberculosis. Journal of Antimicrobial Chemotherapy 40, 885-8.
16. Meier, A., Sander, P., Schaper, K. J., Scholz, M. & Bottger, E. C. (1996). Correlation of molecular resistance mechanisms and phenotypic resistance levels in streptomycin-resistant Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy 40, 2452-4.
17. Andersson, M. (1990). Solid-phase synthesis of a 31-residue mammalian cecropin and its C-terminally amidated analogue. Journal of Protein Chemistry 9, 359.
18. Snider, D. E., Jr, Good, R. C., Kilburn, J. O., Laskowski, L. F., Jr, Lusk, R. H., Marr, J. J. et al. (1981). Rapid drug-susceptibility testing of Mycobacterium tuberculosis. American Review of Respiratory Disease 123, 402-6.
19. Middlebrook, G., Reggiardo, Z. & Tigertt, W. D. (1977). Automatable radiometric detection of growth of Mycobacterium tuberculosis in selective media. American Review of Respiratory Diseases 115, 1066-9.
20. Heifets, L. B., Iseman, M. D., Lindholm-Levy, P. J. & Kanes, W. (1985). Determination of ansamycin MICs for Mycobacterium avium complex in liquid medium by radiometric and conventional methods. Antimicrobial Agents and Chemotherapy 28, 570-5.
21. Heifets, L. B., Iseman, M. D. & Lindholm-Levy, P. J. (1986). Ethambutol MICs and MBCs for Mycobacterium avium complex and Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy 30, 927-32.
22. Agerberth, B., Grunewald, J., Castanos-Velez, E., Olsson, B., Jörnvall, H., Wigzell, H. et al. (1999). Antibacterial components in bronchoalveolar lavage fluid from healthy individuals and sarcoidosis patients. American Journal of Respiratory and Critical Care Medicine 160, 283-90.
23. Pedrosa, J., Saunders, B. M., Appelberg, R., Orme, I. M., Silva, M. T. & Cooper, A. M. (2000). Neutrophils play a protective nonphagocytic role in systemic Mycobacterium tuberculosis infection of mice. Infection and Immunity 68, 577-83.
24. Brown, A. E., Holzer, T. J. & Andersen, B. R. (1987). Capacity of human neutrophils to kill Mycobacterium tuberculosis. Journal of Infectious Diseases 156, 985-9.
25. May, M. E. & Spagnuolo, P. J. (1987). Evidence for activation of a respiratory burst in the interaction of human neutrophils with Mycobacterium tuberculosis. Infection and Immunity 55, 2304-7.
26. Denis, M. (1991). Human neutrophils, activated with cytokines or not, do not kill virulent Mycobacterium tuberculosis. Journal of Infectious Diseases 163, 919-20.
27. Majeed, M., Perskvist, N., Ernst, J. D., Orselius, K. & Stendahl, O. (1998). Roles of calcium and annexins in phagocytosis and elimination of an attenuated strain of Mycobacterium tuberculosis in human neutrophils. Microbial Pathogenesis 24, 309-20.
28. Jones, G. S., Amirault, H. J. & Andersen, B. R. (1990). Killing of Mycobacterium tuberculosis by neutrophils: a nonoxidative process. Journal of Infectious Diseases 162, 700-4.
29. Ganz, T., Selsted, M. E., Szklarek, D., Harwig, S. S., Daher, K., Bainton, D. F. et al. (1985). Defensins. Natural peptide antibiotics of human neutrophils. Journal of Clinical Investigation 76, 1427-35.
30. Bonetto, V., Andersson, M., Bergman, T., Sillard, R., Norberg, A., Mutt, V. et al. (1999). Spleen antibacterial peptides: high levels of PR-39 and presence of two forms of NK-lysin. Cellular and Molecular Life Sciences 56, 174-8.
31. Ganz, T. (1987). Extracellular release of antimicrobial defensins from human polymorphonuclear leukocytes. Infection and Immunity 55, 568-71.
32. Zhang, G., Ross, C. R., Dritz, S. S., Nietfeld, J. C. & Blecha, F. (1997). Salmonella infection increases porcine antibacterial peptide concentrations in serum. Clinical and Diagnostic Laboratory Immunology 4, 774-7.
33. Territo, M. C., Ganz, T., Selsted, M. E. & Lehrer, R. (1989). Monocyte-chemotactic activity of defensins from human neutrophils. Journal of Clinical Investigation 84, 2017-20.
34. Chan, Y. R. & Gallo, R. L. (1998). PR-39, a syndecan-inducing antimicrobial peptide, binds and affects p130(Cas). Journal of Biological Chemistry 273, 28978-85.
35. Peschel, A., Otto, M., Jack, R. W., Kallbacher, H., Jung, G. & Götz, F. (1999). Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides. Journal of Biological Chemistry 274, 8405-10.
36. Guo, L., Lim, K. B., Poduje, C. M., Daniel, M., Gunn, J. S., Hackett, M. et al. (1998). Lipid A acylation and bacterial resistance against vertebrate antimicrobial peptides. Cell 95, 189-98.
37. Shafer, W. M., Qu, X.-D., Waring, A. J. & Lehrer, R. I. (1998). Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family. Proceedings of the National Academy of Sciences, USA 95, 1829-33.