The glutathione-related detoxification system is increased in human breast cancer in correlation with clinical and histopathological features

Journal of Cancer Research and Clinical Oncology

Volumn 127, Issue 6, 2001, Pages 368-374

  Perquin, Magali ^a   Oster, Thierry ^a   Maul, Armand ^a   Froment, Nicolas ^b   Untereiner, Michel ^c   Bagrel, Denyse ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

^b Bon Secours Hospital   (France)

^c Centre François Baclesse   (Luxembourg)

Author keywords

Breast cancer; Glutathione pathway; Proliferation markers; Resistance

Indexed keywords

CATHEPSIN D; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; ISOENZYME;

ADULT; AGED; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER INVASION; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL;

ADULT; AGED; BREAST NEOPLASMS; CATHEPSIN D; DRUG RESISTANCE, NEOPLASM; FEMALE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; HUMANS; MENOPAUSE; METABOLIC DETOXICATION, DRUG; MIDDLE AGED; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN;

EID: 0035001370     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004320000228     Document Type: Article

References (30)

1. Aceto A, Di Ilio C, Lo Bello M, Bucciarelli T, Angelucci S, Federici G (1990) Differential activity of human, rat, mouse and bacteria glutathione transferase isoenzymes towards 4-nitroquinoline 1-oxide. Carcinogenesis 11: 2267-2269
2. Akiyama S, Chen ZS, Sumizawa T, Furukawa T (1999) Resistance to cisplatin. Anticancer Drug Des 14: 143-151
3. Benderra Z, Trussardi A, Morjani H, Villa AM, Doglia SM, Manfait M (2000) Regulation of cellular glutathione modulates nuclear accumulation of daunorubicin in human MCF7 cells overexpressing multidrug resistance associated protein. Eur J Cancer 36: 428-434
4. Buser K, Joncourt F, Altermatt HJ, Bacchi M, Oberli A, Cerny T (1997) Breast cancer: pretreatment drug resistance parameters (GSH-system, ATase, P-glycoprotein) in tumor tissue and their correlation with clinical and prognostic characteristics. Ann Oncol 8: 335-341
5. Carlberg I, Mannervick B (1975) Purification and characterization of the flavoenzyme glutathione reductase from rat liver. J Biol Chem 250: 5475-5480
6. Carmagnol F, Sinet PM, Jérôme H (1983) Selenium-dependent and non-selenium-dependent glutathione peroxidases in human tissue extracts. Biochim Biophys Acta 759: 49-57
7. 6-alkylguanine-DNA-alkyltransferase of human tumour xenografts. Eur J Cancer 34: 1749-1755
8. Dogru-Abbasoglu S, Aykac-Toker G, Locak T, Unluer E, Uysal M (1999) Antioxidant enzyme activities and lipid peroxides in the plasma of patients with benign prostatic hyperplasia or prostate cancer are not predictive. J Cancer Res Clin Oncol 125: 402-404
9. Hall AG (1999) The role of glutathione in the regulation of apoptosis. Eur J Clin Invest 29: 238-245
10. Harman D (1992) Free radical theory of aging. Mutat Res 275: 257-266
11. Hayes JD, Pulford DJ (1995) The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 30: 445-600
12. Ishii M, Iwahana M, Mitsui I, Minami M, Imagawa S, Tohgo A, Ejima A (2000) Growth inhibitory effect of a new camptothecin analog, DX-8951f, on various drug-resistant sublines including BCRP-mediated camptothecin derivative-resistant variants derived from the human lung cancer cell line PC-6. Anticancer Drugs 11: 353-362
13. Kelley MK, Engqvist-Goldstein A, Montali JA, Wheatley JB, Schmidt DE Jr, Kauvar LM (1994) Variability of glutathione S-transferase isoenzyme patterns in matched normal and cancer human breast tissue. Biochem J 304: 843-8
14. Kute TE, Quadri Y, Muss H, Zbieranski N, Cirrincione C, Berry DA, Barcos M, Thor AP, Liu E, Koerner F, Henderson IC (1995) Flow cytometry in node-positive breast cancer: cancer and leukemia group B protocol 8869. Cytometry 22: 297-306
15. Lacave R, Coulet F, Ricci S, Touboul E, Flahault A, Rateau JG, Cesari D, Lefranc JP, Bernaudin JF (1998) Comparative evaluation by semiquantitative reverse transcriptase polymerase chain reaction of MDR1, MRP, and GST π gene expression in breast carcinomas. Br J Cancer 77: 694-702
16. Leroy P, Nicolas A, Wellman M, Michelet F, Oster T, Siest G (1993) Evaluation of o-phthalaldehyde as bifunctional fluorogenic post-column reagent for glutathione in liquid chromatography. Chromatographia 36: 130-134
17. Lowry OH, Rosebrough NJ, Farr AL, Randall RL (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275
18. Marx D, Schauer A, Reiche C, May A, Ummenhofer L, Reles A, Rauschecker H, Sauer R, Schumacher M (1990) c-ErbB-2 expression in correlation to other biological parameters of breast cancer. J Cancer Res Clin Oncol 116: 15-20
19. Morrow CS, Smitherman PK, Diah SK, Schneider E, Townsend AJ (1998) Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification. Mechanism of GST A1 - 1-and MRP1-associated resistance to chlorambucil in MCF7 breast carcinoma cells. J Biol Chem 273: 20114-20120
20. Muss HB, Thor AD, Berry DA, Kute T, Liu ET, Koerner F, Cirrincione CT, Budman DR, Wood WC, Barcos M, Henderson IC (1994) c-ErbB-2 expression and response to adjuvant therapy in women with node-positive early breast cancer. N Engl J Med 330: 1260-1266
21. Perry RR, Mazetta JA, Levin M, Barranco SC (1993) Glutathione levels and variability in breast tumors and normal tissues. Cancer 72: 783-787
22. Punnonen K, Ahotupa M, Asaishi K, Hyoty M, Kudo R, Punnonen R (1994) Antioxidant enzyme activities and oxidative stress in human breast cancer. J Cancer Res Clin Oncol 120: 374-377
23. Ravaioli A, Bagli L, Zucchini A, Monti F (1998) Prognosis and prediction of response in breast cancer: the current role of the main biological markers. Cell Prolif 31: 113-126
24. Richie JP Jr (1992) The role of glutathione in aging and cancer. Exp Gerontol 27: 615-626
25. Severini G (1993) Glutathione S-transferase activity in patients with cancer of the digestive tract. J Cancer Res Clin Oncol 120: 112-114
26. Silvestrini R, Veneroni S, Benini E, Daidone MG, Luisi A, Leutner M, Maucione A, Kenda R, Zucali R, Veronesi U (1997) Expression of p53, glutathione S-transferase-pi, and Bc1-2 proteins and benefit from adjuvant radiotherapy in breast cancer. J Natl Cancer Inst 89: 639-645
27. Tagliabue E, Menard S, Robertson JF, Harris L (1999) c-ErbB-2 expression in primary breast cancer. Int J Biol Markers 14: 16-26
28. Tew KD, O'Brien M, Laing NM, Shen H (1998) Coordinate changes in expression of protective genes in drug-resistant cells. Chem Biol Interact 111-112: 199-211
29. Tsuchida S, Sato K (1992) Glutathione transferases and cancer. Crit Rev Biochem Mol Biol 27: 337-384
30. Van der Zee AG, Hollema H, Suurmeijer AJ, Krans M, Sluiter WJ, Willemse PH, Aalders JG, de Vries EG (1995) Value of P-glycoprotein, glutathione S-transferase π, c-erbB-2, and p53 as prognostic factors in ovarian carcinomas. J Clin Oncol 13: 70-78