Common variants in the regulatory region of the insulin gene are associated with fasting plasma insulin levels in juvenile obesity

European Journal of Endocrinology

Volumn 144, Issue 5, 2001, Pages 457-459

  Undlien, Dag E ^a   Berg, Jens P ^b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b AKER UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; MESSENGER RNA;

ADULT; ALLELE; ARTICLE; BODY MASS; CHILD; CHROMOSOME 11; DISEASE MARKER; DNA POLYMORPHISM; FEMALE; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; HUMAN; INSULIN BLOOD LEVEL; INSULIN RELEASE; JUVENILE; LIPID STORAGE; MALE; MORBID OBESITY; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; REGULATOR GENE; RNA TRANSCRIPTION; THYMUS; VARIABLE NUMBER OF TANDEM REPEAT;

EID: 0035001307     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1440457     Document Type: Article

References (17)

1. Bell GI, Karam JH & Rutter WJ. Polymorphic DNA region adjacent to the 5′ end of the human insulin gene. PNAS 1981 78 5759-5763.
2. Bennett ST & Todd JA. Human type 1 diabetes and the insulin gene: principles of mapping polygenes. Annual Review of Genetics 1996 30 343-370.
3. Stead JD, Buard J, Todd JA & Jeffreys AJ. Influence of allele lineage on the role of the insulin minisatellite in susceptibility to type 1 diabetes. Human Molecular Genetics 2000 9 2929-2935.
4. Stead JD & Jeffreys AJ. Allele diversity and germline mutation at the insulin minisatellite. Human Molecular Genetics 2000 9 713-723.
5. Lucassen AM, Julier C, Beressi JP, Boitard C, Froguel P, Lathrop M et al. Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR. Nature Genetics 1993 4 305-310.
6. Bell GI, Horita S & Karam JH. A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus. Diabetes 1984 33 176-183.
7. Bennett ST, Lucassen AM, Gough SC, Powell EE, Undlien DE, Pritchard LE et al. Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nature Genetics 1995 9 284-292.
8. Lucassen AM, Screaton GR, Julier C, Elliott TJ, Lathrop M & Bell JI. Regulation of insulin gene expression by the IDDM associated, insulin locus haplotype. Human Molecular Genetics 1995 4 501-506.
9. Kennedy GC, German MS & Rutter WJ. The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription. Nature Genetics 1995 9 293-298.
10. Vafiadis P, Bennett ST, Todd JA, Nadeau J, Grabs R, Goodyer CG et al. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nature Genetics 1997 15 289-292.
11. Le Stunff C, Fallin D, Schork NJ & Bougneres P. The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity. Nature Genetics 2000 26 444-446.
12. Ong KKL, Phillips DI, Fall C, Poulton J, Bennett ST, Golding J et al. The insulin gene VNTR, type 2 diabetes and birth weight. Nature Genetics 1999 21 262-263.
13. Huxtable SJ, Saker PJ, Haddad L, Walker M, Frayling TM, Levy JC et al. Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles. Diabetes 2000 49 126-130.
14. O'Dell SD, Bujac SR, Miller GJ & Day IN. Associations of IGF2 Apal RFLP and INS VNTR class I allele size with obesity. European Journal of Human Genetics 1999 7 821-827.
15. Pugliese A, Zeller M, Fernandez A Jr, Zalcberg LJ, Bartlett RJ, Ricordi C et al. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nature Genetics 1997 15 293-297.
16. Waterworth DM, Bennett ST, Gharani N, McCarthy MI, Hague S, Batty S et al. Linkage and association of insulin gene VNTR regulatory polymorphism with polycystic ovary syndrome. Lancet 1997 349 986-990.
17. Dunger DB, Ong KKL, Huxtable SJ, Sherriff A, Woods KA, Ahmed ML et al. Association of the INS VNTR with size at birth. Nature Genetics 1998 19 98-100.