Regulation of both gene expression and protein stability provides genetically assisted target evaluation (GATE) for microbial target validation

Pharmacogenomics

Volumn 2, Issue 2, 2001, Pages 95-106

  Buurman, E T ^a   Bradley, J D ^a   Donnelly, C E ^a   Moore, J B ^a   Healy, J M ^a   Averett, D R ^a   Thompson, C M ^a   Wobbe, C R ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Anti infectives; Cidality; Copper ions; Genomics; Regulation; Saccharomyces cerevisiae; Target

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; COPPER ION; GENE PRODUCT; NEW DRUG;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL THERAPY; ARTICLE; CANDIDA ALBICANS; DRUG TARGETING; GENE EXPRESSION; GENETICALLY ASSISTED TARGET EVALUATION; GENOME; LETHALITY; MICROBIAL GROWTH; MICROORGANISM; NONHUMAN; PROTEIN STABILITY; PROTEIN SYNTHESIS; SACCHAROMYCES CEREVISIAE; SURVIVAL; TECHNOLOGY; VALIDATION PROCESS;

ANIMALS; ANTI-INFECTIVE AGENTS; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION; GENE TARGETING; HUMANS; PROTEINS;

EID: 0035001244     PISSN: 14622416     EISSN: None     Source Type: Journal    
DOI: 10.1517/14622416.2.2.95     Document Type: Article

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