HLA-DRB1 gene transcripts in rheumatoid arthritis

Clinical and Experimental Immunology

Volumn 124, Issue 1, 2001, Pages 142-149

  Kerlan Candon, S ^a   Combe, B ^a   Vincent, R ^a   Clot, J ^a   Pinet, V ^a   Eliaou, J F ^a,b  

^a MONTPELLIER UNIVERSITY HOSPITAL   (France)

^b HÔPITAL SAINT ELOI   (France)

Author keywords

B lymphocytes; Competitive PCR; MHC class II; mRNA

Indexed keywords

CD4 ANTIGEN; CORTICOSTEROID; CYCLOSPORIN; GOLD SALT; HLA DR ANTIGEN; HYDROXYCHLOROQUINE; LEFLUNOMIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; METHOTREXATE; SALAZOSULFAPYRIDINE;

ADULT; ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENE EXPRESSION; GENETIC LINKAGE; GENETIC TRANSCRIPTION; GENOTYPE; HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; T LYMPHOCYTE;

ALLELES; ARTHRITIS, RHEUMATOID; AUTOIMMUNE DISEASES; GENE EXPRESSION REGULATION; GENES, MHC CLASS II; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HLA-DR ANTIGENS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0035000487     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2001.01498.x     Document Type: Article

References (30)

1. 1 Gregersen P, Silver J, Winchester R. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987; 30:1205-13.
2. 2 Fox D. The role of T cells in the immunopathogenesis of rheumatoid arthritis. Arthritis Rheum 1996; 40:598-605.
3. 3 Janeway C, Bottomly K, Babish J et al. Quantitative variation in Ia antigen expression plays a central role in immune regulation. Immunol Today 1984; 5:99-101.
4. 4 Lechler R, Norcross M, Germain R. Qualitative and quantitative studies of antigen-presenting cell function by using I-A-expressing L cells. J Immunol 1985; 135:2914-22.
5. 5 Louis P, Eliaou J-F, Candon S et al. Polymorphism in the regulatory region of HLA-DRB genes correlating with haplotype evolution. Immunogenetics 1993; 38:21-6.
6. 6 Louis P, Vincent R, Cavadore P et al. Differential transcriptional activities of HLA-DR genes in the various haplotypes. J Immunol 1994; 153:5059-67.
7. 7 Vincent R, Louis P, Gongora C et al. Quantitative analysis of the expression of the HLA-DRB genes at the transcriptional level by competitive polymerase chain reaction. J Immunol 1996; 156:603-10.
8. 8 Andersen LC, Beaty JS, Nettles JW et al. Allelic polymorphism in trascriptional regulatory regions of HLA-DQB genes. J Exp Med 1991; 173:181-92.
9. 9 Singal DP, Qiu X. Polymorphism in the upstream regulatory region and level of expression of HLADRB genes. Mol Immunol 1994; 31:1117-20.
10. 10 Morzycka-Wroblewska E, Munshi A, Ostermayer M et al. Differential expression of HLA-DQA1 alleles associated with promoter polymorphism. Immunogenetics 1997; 45:163-70.
11. 11 Teyton L, Lotteau V, Turmel P et al. HLA-DR, DQ and DP antigen expression in rheumatoid synovial cells; a biochemical and quantitative study. J Immunol 1987; 138:1730-5.
12. 12 Eliaou J-F, Andary M, Favier F et al. Increase of class II HLA molecules on the membrane of B lymphocytes from patients with rheumatoid arthritis. Autoimmunity 1988; 1:217-22.
13. 13 Arnett FC, Edworthy SM, Bloch DA et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31:315-24.
14. 14 Combe B, Eliaou J-F, Daures J-P et al. Prognostic factors in rheumatoid arthritis. Comparative study of two subsets of patients according to severity of articular damage. Br J Rheumatol 1995; 34:529-34.
15. 15 Louis-Plence P, Kerlan-Candon S, Morel J et al. The down-regulation of HLA-DM genes expression in Rheumatoid Arthritis in not related to their promoter polymorphism. J Immunol 2000; 165:4861-9.
16. 16 Weyand C, Hicok K, Conn D et al. The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis. Ann Int Med 1992; 117:801-6.
17. 17 Gough A, Faint J, Salmon M et al. Genetic typing of patients with inflammatory arthritis at presentation can be used to predict outcome. Arthritis Rheum 1994; 37:1166-70.
18. 18 Müller-Ladner U, Roberts CR, Franklin BN et al. Human IL-1Ra gene transfer into human synovial fibroblasts is chondroprotective. J Immunol 1997; 158:3492-8.
19. 19 Moreland AW, Heck LW, Koopman WJ. Biologic agents for treating rheumatoid arthritis. Arthritis Rheum 1997; 40:397-409.
20. 20 Jouvenne P, Chaudhary A, Buchs N et al. Possible genetic association between interleukin-1alpha gene polymorphism and the severity of chronic polyarthritis. Eur Cytokine Netw 1999; 10:33-6.
21. 21 Hajeer AH, Lazarus M, Turner D et al. IL-10 gene promoter polymorphism in rheumatoid arthritis. Scand J Rheumatol 1998; 27:142-5.
22. 22 Cantagrel A, Navaux F, Loubet-Lescoulie P et al. Interleukin-1beta, interleukin-1 receptor antagonist, interleukin-4, and interleukin-10 gene polymorphisms: relationship to occurrence and severity of rheumatoid arthritis. Arthritis Rheum 1999; 42:1093-100.
23. 23 Rohn W, Tang LP, Dong Y et al. IL-1 beta inhibits IFN-gamma-induced class II MHC expression by suppressing transcription of the class II transactivator gene. J Immunol 1999; 162:886-96.
24. 24 Go NF, Castle B, Barrett R et al. IL-10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells. J Exp Med 1990; 172:1625-31.
25. 25 Ding L, Linsley PS, Huang L-Y et al. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulatiori of B7 expression. J Immunol 1993; 151:1224-34.
26. 26 Glimcher LH, Kara CJ. Sequences and factors: a guide to MHC class II transcription. Annu Rev Immunol 1992; 10:13-49.
27. 27 Czerwony G, Alten R, Gromnica-Ihle R et al. Differential surface expression of HLA-DRB1 and HLA-DRB4 among peripheral blood cells of DR4 positive individuals. Hum Immunol 1999; 60:1-9.
28. 28 Constantin A, Loubet-Lescoulié P, Lambert N et al. Anti-inflammatory and immunoregulatory action of methotrexate in the treatment of rheumatoid arthritis. Arthritis Rheum 1998; 41:48-57.
29. 29 Fertsch D, Schoenberg DR, Germain RN et al. Induction of macrophage Ia antigen expression by rIFN-γ and down-regulation by IFN-α/β and dexamethasone are mediated by changes in steady state levels of Ia mRNA. J Immunol 1987; 139:244-9.
30. 30 Koerner TJ, Hamilton TA, Adams DO. Suppressed expression of surface Ia antigen on macrophages by lipopolysaccharide: evidence for regulation at the level of accumulation of mRNA expression by rIFN-γ. J Immunol 1987; 139:239-43.