Enhanced endothelin-1 response and receptor expression in small mesenteric arteries of insulin-resistant rats

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 280, Issue 2 49-2, 2001, Pages

  Katakam, Prasad V G ^a,c   Pollock, Jennifer S ^b   Pollock, David M ^b   Ujhelyi, Michael R ^a,c   Miller, Allison W ^a,c,d  

^a UNIVERSITY OF GEORGIA   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

ETA; ETB; Hyperinsulinemia

Indexed keywords

4 (1,3 BENZODIOXOL 5 YL) 1 [(2,6 DIETHYLPHENYL)CARBAMOYLMETHYL] 2 (4 PROPOXYPHENYL) 3 PYRROLIDINECARBOXYLIC ACID; ATRASENTAN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST; ENDOTHELIN RECEPTOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; HORMONE RECEPTOR INTERACTION; HORMONE RESPONSE; INSULIN RESISTANCE; MALE; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RAT;

EID: 0035000090     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.280.2.h522     Document Type: Article

References (17)

1. Ferrannini E, Buzzigoli G, Bonadonna R, Giorico MA, Oleggini M, Graziadei L, Pedrinelli R, Brandi L, and Bevilacqua S. Insulin resistance in essential hypertension. N Engl J Med 317: 350-357, 1987.
2. Ferri C, Bellini C, Desideri G, Baldoncini R, DeSiati L, and Santucci A. Elevated plasma endothelin-1 levels as an additional risk factor in non-obese essential hypertensive patients with metabolic abnormalities. Diabetologia 40: 100-102, 1997.
3. Ferri C, Bellini C, Desideri G, DeMattia G, and Santucci A. Endogenous insulin modulates circulating endothelin-1 concentrations in humans. Diabetes Care 19: 504-506, 1996.
4. Herbert V, Lau K, and Gottlieb CW. Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab 25: 1375-1384, 1965.
5. A receptor expression in rat aortic smooth muscle cells. Diabetes 47: 937-944, 1998.
6. Howard G, O'Leary DH, Zaccaro D, Haffner S, Rewers M, Hamman R, Selby JV, Saad MF, Savage P, and Bergman R (for the IRAS Investigators). Insulin sensitivity and atherosclerosis. Circulation 93: 1809-1817, 1996.
7. Juan CC, Fang VS, Hsu YP, Huang YJ, Hsia DB, Yu PC, Kwok CF, and Ho LT. Overexpression of vascular endothelin-1 and endothelin-A receptors in a fructose-induced hypertensive rat model. J Hypertens 16: 1775-1782, 1998.
8. Katakam PVG, Ujhelyi MR, Hoenig ME, and Miller AW. Endothelial dysfunction precedes hypertension in diet-induced insulin resistance. Am J Physiol Regulatory Integrative Comp Physiol 275: R788-R792, 1998.
9. Katakam PVG, Ujhelyi MR, and Miller AW. EDHF mediated relaxation is impaired in fructose fed rats. J Cardiovasc Pharmacol 34: 461-467, 1999.
10. Levin ER. Endothelins. N Engl J Med 333: 356-363, 1995.
11. Navarro-Cid J, Maeso R, Vizcaino FP, Cachofeiro V, Ruilope LM, Tamargo J, and Lahera V. Effects of losartan on blood pressure, metabolic alterations, and vascular reactivity in the fructose-induced hypertensive rat. Hypertension 26: 1074-1078, 1995.
12. Piatti P, Monti LD, Conti M, Baruffaldi L, Galli L, Phan CV, Guazzini B, Pontiroli AE, and Pozza G. Hypertriglyceidemia and hyperinsulinemia are potent inducers of endothelin-1 release in humans. Diabetes 45: 316-321, 1996.
13. Pollock DM. Endothelin receptor subtypes and tissue distrubution. In: Endothelin: Molecular Biology, Physiology, and Pathology. Totowa, NJ: Humana, 1997, p. 1-29.
14. Pollock DM, Allcock GH, Krishnan A, Dayton BD, and Pollock JS. Upregulation of endothelin-B receptors in kidneys of DOCA-salt hypertensive rats. Am J Physiol Renal Physiol 278: F279-F286, 2000.
15. Verma S, Banot S, and McNeill JH. Effect of chronic endothelin blockade in hyperinsulinemic hypertensive rats. Am J Physiol Heart Circ Physiol 269: H2017-H2021, 1995.
16. Verma S, Bhanot S, Yao L, and McNeill JH. Defective endothelium-dependent relaxation in fructose-hypertensive rats. Am J Hypertens 9: 370-376, 1996.
17. Verma S, Skarsgard P, Bhanot S, Yao L, Laher I, and McNeill JH. Reactivity of mesenteric arteries from fructose hypertensive rats to endothelin-1. Am J Hypertens 10: 1010-1019, 1997.