Acetylcholine-induced desensitization of the contractile response to histamine in guinea pig ileum is prevented by either pertussis toxin treatment or by selective inactivation of muscarinic M3 receptors

Journal of Pharmacology and Experimental Therapeutics

Volumn 297, Issue 3, 2001, Pages 1152-1159

  Shehnaz, Darakhshanda ^a   Ansari, Khurram Z ^a   Ehlert, Frederick J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; ACETYLCHOLINE; HISTAMINE; INOSITOL PHOSPHATE; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; PERTUSSIS TOXIN; PHOSPHOLIPASE C;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; GUINEA PIG; ILEUM; MALE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DENSITY; SMOOTH MUSCLE CONTRACTILITY;

ACETYLCHOLINE; ANIMALS; DIPHENYLACETIC ACIDS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUINEA PIGS; HISTAMINE; ILEUM; INOSITOL PHOSPHATES; ISOENZYMES; MALE; MUSCARINIC ANTAGONISTS; MUSCLE CONTRACTION; PERTUSSIS TOXIN; PHOSPHOLIPASE C; PIPERIDINES; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M3; RECEPTORS, MUSCARINIC; VIRULENCE FACTORS, BORDETELLA;

EID: 0034999178     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Abdel-Latif AA (1986) Calcium-mobilizing receptors, polyphosphoinositides, and the generation of second messengers. Pharmacol Rev 38:227-272.
2. Arrang JM, Drutel G, Garbarg M, Ruat M, Traiffort E and Schwartz JC (1995) Molecular and functional diversity of histamine receptor subtypes. Ann NY Acad Sci 757:314-323.
3. Berridge MJ (1984) Inositol trisphosphate and diacylglycerol as second messengers. Biochem J 220:345-360.
4. Berridge MJ, Downes CP and Hanley MR (1982) Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochem J 206:587-595.
5. Black JW, Duncan WA, Durant CJ, Ganellin CR and Parsons EM (1972) Definition and antagonism of histamine H 2 -receptors. Nature (Lond) 236:385-390.
6. Bolton TB (1979) Mechanisms of action of transmitters and other substances on smooth muscle. Physiol Rev 59:606-718.
7. Candell LM, Yun SH, Tran LL and Ehlert FJ (1990) Differential coupling of subtypes of the muscarinic receptor to adenylate cyclase and phosphoinositide hydrolysis in the longitudinal muscle of the rat ileum. Mol Pharmacol 38:689-697.
8. Cantoni GL and Eastman G (1946) On the response of the intestine to smooth muscle stimulants. J Pharmacol Exp Ther 87:392-399.
9. Dale MM (1958) An inhibitory effect of acetylcholine on the response of the guinea-pig ileum to histamine. Br J Pharmacol 13:17-19.
10. Dell'Acqua ML, Carroll RC and Peralta EG (1993) Transfected m2 muscarinic acetylcholine receptors couple to G alpha i2 and G alpha i3 in Chinese hamster ovary cells. Activation and desensitization of the phospholipase C signaling pathway. J Biol Chem 268:5676-5685.
11. Eglen RM, Adham N and Whiting RL (1992) Acute desensitization of muscarinic receptors in the isolated guinea-pig ileal longitudinal muscle. J Auton Pharmacol 12:137-148.
12. Eglen RM, Hegde SS and Watson N (1996) Muscarinic receptor subtypes and smooth muscle function. Pharmacol Rev 48:531-565.
13. Eglen RM, Huff MM, Montgomery WW and Whiting RL (1988) Differential effects of pertussis toxin on muscarinic responses in isolated atria and smooth muscle. J Auton Pharmacol 8:29-37.
14. Eglen RM and Whiting RL (1987) Estimation of apparent agonist affinity constants using desensitization of the ileal muscarinic receptor. J Pharmacol Exp Ther 240:404-409.
15. Ehlert FJ, Sawyer GW and Esqueda EE (1999) Contractile role of M2 and M3 muscarinic receptors in gastrointestinal smooth muscle [published erratum appears in Life Sci (1999) 64:2535]. Life Sci 64:387-394.
16. Ehlert FJ, Thomas EA, Gerstin EH and Griffin MT (1997) Muscarinic receptors and gastrointestinal smooth muscle, in Muscarinic Receptor Subtypes in Smooth Muscle (Eglen RM ed) pp 92-147, CRC Press, Boca Raton, FL.
17. Gosselin RE and Gosselin RS (1973) Tachyphylaxis of guinea-pig ileum to histamine and furtrethonium. J Pharmacol Exp Ther 184:494-505.
18. Griffin MT and Ehlert FJ (1992) Specific inhibition of isoproterenol-stimulated cyclic AMP accumulation by M2 muscarinic receptors in rat intestinal smooth muscle. J Pharmacol Exp Ther 263:221-225.
19. Hermans E, Saunders R, Selkirk JV, Mistry R, Nahorski SR and Challiss RAJ (2000) Complex involvement of pertussis toxin-sensitive G proteins in the regulation of type 1a metabotropic glutamate receptor signaling in baby hamster kidney cells. Mol Pharmacol 58:352-360.
20. Ishii K and Kato R (1987) Suppression by muscarinic M2 stimulation of the contractile mechanism via histamine H1 receptors in the longitudinal muscle of guinea pig ileum. J Pharmacol Exp Ther 241:587-593.
21. 3H]inositol phospholipid turnover, in Methods in Neurotransmitter Receptor Analysis (Yamamura HI ed) pp 68-87, Raven Press, New York.
22. Lai J, Waite SL, Bloom JW, Yamamura HI and Roeske WR (1991) The m2 muscarinic acetylcholine receptors are coupled to multiple signaling pathways via pertussis toxin-sensitive guanine nucleotide regulatory proteins. J Pharmacol Exp Ther 258:938-944.
23. Lambrecht G, Feifel R, Moser U, Wagner-Roder M, Choo LK, Camus J, Tastenoy M, Waelbroeck M, Strohmann C, Tacke R, Rodrigues de Miranda JF, Christophe J and Mutschler E (1989) Pharmacology of hexahydro-difenidol, hexahydro-siladifenidol and related selective muscarinic antagonists. Trends Pharmacol Sci Suppl:60-64.
24. Leurs R, Smit MJ, Brozius MM, Jansen W, Bast A and Timmerman H (1991) Is protein kinase C involved in histamine H1-receptor desensitization? Agents Actions Suppl 33:393-402.
25. Matsui M, Motomura D, Karasawa H, Fujikawa T, Jiang J, Komiya Y, Takahashi S and Taketo MM (2000) Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype. Proc Natl Acad Sci USA 97:9579-9584.
26. 2 muscarinic receptor inhibition of agonist-induced cyclic adenosine monophosphate accumulation and relaxation in the guinea pig ileum. J Pharmacol Exp Ther 280:1-11.
27. Ostrom RS and Ehlert FJ (1999) Comparison of functional antagonism between isoproterenol and M2 muscarinic receptors in guinea pig ileum and trachea. J Pharmacol Exp Ther 288:969-976.
28. Paton WDM (1961) A theory of drug action based on the rate of drug-receptor combination. Proc R Soc Lond B Biol Sci 154:21-69.
29. Paton WD and Vizi ES (1969) The inhibitory action of noradrenaline and adrenaline on acetylcholine output by guinea-pig ileum longitudinal muscle strip. Br J Pharmacol 35:10-28.
30. Peralta EG, Ashkenazi A, Winslow JW, Ramachandran J and Capon DJ (1988) Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes. Nature (Lond) 334:434-437.
31. Reddy H, Watson N, Ford AP and Eglen RM (1995) Characterization of the interaction between muscarinic M2 receptors and beta-adrenoceptor subtypes in guinea-pig isolated ileum. Br J Pharmacol 114:49-56.
32. Sawyer GW and Ehlert FJ (1998) Contractile role of the M2 and M3 muscarinic receptors in the guinea pig colon. J Pharmacol Exp Ther 284:269-277.
33. Sawyer G and Ehlert F (1999a) Pertussis toxin increases isoproterenol induced relaxation in field-stimulated ileum [published erratum appears in Eur J Pharmacol (1999) 372:329]. Eur J Pharmacol 367:81-84.
34. Sawyer GW and Ehlert FJ (1999b) Muscarinic M3 receptor inactivation reveals a pertussis toxin-sensitive contractile response in the guinea pig colon. J Pharmacol Exp Ther 289:464-476.
35. Stengel PW, Gomeza J, Wess J and Cohen ML (2000) M(2) and M(4) receptor knockout mice: muscarinic receptor function in cardiac and smooth muscle in vitro. J Pharmacol Exp Ther 292:877-885.
36. Thomas EA, Baker SA and Ehlert FJ (1993) Functional role for the M2 muscarinic receptor in smooth muscle of guinea pig ileum. Mol Pharmacol 44:102-110.
37. Thomas EA and Ehlert FJ (1994) Pertussis toxin blocks M2 muscarinic receptor-mediated effects on contraction and cyclic AMP in the guinea pig ileum, but not M3-mediated contractions and phosphoinositide hydrolysis. J Pharmacol Exp Ther 271:1042-1050.
38. Thomas EA, Hsu HH, Griffin MT, Hunter AL, Luong T and Ehlert FJ (1992) Conversion of N-(2-chloroethyl)-4-piperidinyl diphenylacetate (4-DAMP mustard) to an aziridinium ion and its interaction with muscarinic receptors in various tissues. Mol Pharmacol 41:718-726.
39. Wang XB, Osugi T and Uchida S (1993) Muscarinic receptors stimulate Ca2+ influx via phospholipase A2 pathway in ileal smooth muscles. Biochem Biophys Res Commun 193:483-489.
40. Zhang LB and Buxton IL (1991) Muscarinic receptors in canine colonie circular smooth muscle. II. Signal transduction pathways. Mol Pharmacol 40:952-959.