Smart screening: Approaches to efficient HTS

Current Opinion in Drug Discovery and Development

Volumn 4, Issue 3, 2001, Pages 275-283

  Engels, M F M ^a   Venkatarangan, P ^a  

^a JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

Cost efficiency; High throughput screening; In silico screening; Sequential screening

Indexed keywords

COST EFFECTIVENESS ANALYSIS; DRUG SCREENING; DRUG TARGETING; REVIEW; SCREENING TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

COMPUTATIONAL BIOLOGY; COMPUTERS; DATABASES, FACTUAL; DRUG EVALUATION, PRECLINICAL;

EID: 0034994014     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (43)

1. Beyond uHTS: Ridiculously HTS?
2. Optimum utilization of a compound collection or chemical library for drug discovery
3. What is the future of high-throughput screening?
4. Drug discovery: A historical perspective
5. Virtual screening - An overview
6. Compound collections get focused
7. Diversity screening versus focussed screening in drug discovery
8. CerBeruS: A system supporting the sequential screening process
9. Bioactive diversity and screening library selection via affinity fingerprinting
10. Analysis of a large, high-throughput screening data using recursive partitioning
11. Diversity analysis in high-throughput screening
12. Chemical similarity searching
13. Effectiveness of retrieval in similarity searches of chemical databases: A review of performance measures
14. Use of recursive partitioning in the sequential screening of G-protein-coupled receptors
15. Clustering a large number of compounds. 1. Establishing the method on an initial sample
16. Cluster-based selection
17. Subset-selection methods for chemical databases
18. Molecular diversity and representativity in chemical databases
19. VisualiSAR: A web-based application for clustering, structure browsing and structure-activity relationship study
20. Dissimilarity-based compound selection techniques
21. Developmental Therapeutics Program
22. Sequential screening of large compound libraries
23. Analyzing high-throughput screening data by neural networks
24. Self-organizing neural networks for screening and development of novel artificial sweetener candidates
25. Recursive partitioning analysis of a large structure-activity data set using three-dimensional descriptors
26. Analysis of a large structure/biological activity data set using recursive partitioning
27. A sequential approach for identifying lead compounds in large chemical databases
28. Atom pairs as molecular features in structure-activity studies: Definition and applications
29. Topological torsion: A new molecular descriptor for SAR applications: Comparisons with other descriptors
30. Potential drugs and non-drugs: Prediction and identification of important structural features
31. Evolutionary combinatorial chemistry: Application of genetic algorithms
32. Simulated molecular evolution in a full combinatorial library
33. Addressing the problem of molecular diversity
34. Approaches for mining high-throughput screening data sets
35. Comparison of 2D fingerprint types and hierarchy level selection methods for structural grouping using Ward's clustering
36. Giving IT an integral role in research
37. Chemoinformatics: What it is and how does it impact drug discovery
38. Virtual chemical stores
39. Directed diversity: An operating system for combinatorial chemistry