Regulation of sodium channel gene expression by transcriptional silencing

Developmental Neuroscience

Volumn 19, Issue 1, 1996, Pages 25-26

  Eggen, Bart J L ^a   Mandel, Gail ^a  

^a Stony Brook University   (United States)

Author keywords

Neuronal gene expression; REST; Silencer; Transcriptional repressor

Indexed keywords

COMPLEMENTARY DNA; SODIUM CHANNEL; TRANSCRIPTION FACTOR;

ACTION POTENTIAL; CELL LINE; CELL STRAIN; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; GENE EXPRESSION REGULATION; MAMMAL; NERVE CELL; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0031045141     PISSN: 03785866     EISSN: 14219859     Source Type: Journal    
DOI: 10.1159/000111181     Document Type: Article

References (5)

1. Simpson P: Positive and negative regulators of neural fate. Neuron 1995;15:739-742.
2. Kraner SD, Chong JA, Tsay H-J, Mandel G: Silencing the type II sodium channel gene: A model for neural-specific gene regulation. Neuron 1992;9:37-44.
3. Wang MW, Reed RR: Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast. Nature 1993;364: 121-126.
4. Chong JA, Tapia-Ramirez J, Kim S, Toledo-Aral JJ, Zheng Y, Boutros MC, Altschuller YM, Frohman MA, Kraner SD, Mandel G: REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 1995;80:949-957.
5. Schoenherr CJ, Anderson DJ: The neuron-restrictive silencing factor (NRSF): A coordinate repressor of multiple neuron-specific genes. Science 1995;267:1360-1363.