M2 mutations of the nicotinic acetylcholine receptor increase the potency of the non-competitive inhibitor phencyclidine

Journal of Neuroscience Research

Volumn 61, Issue 1, 2000, Pages 44-51

  Eaton, Misty J ^a   Labarca, C ^b   Eterovic V A ^a  

^a SCHOOL OF MEDICINE   (Puerto Rico)

^b CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Nicotinic acetylcholine receptor; Non competitive inhibitor; Phencyclidine; Voltage clamp; Xenopus laevis oocytes

Indexed keywords

NICOTINIC RECEPTOR; PHENCYCLIDINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; COMPETITIVE INHIBITION; DRUG EFFECT; DRUG POTENCY; GENE MUTATION; HYDROPHOBICITY; LIPID BILAYER; MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; VOLTAGE CLAMP;

EID: 0034234481     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4547(20000701)61:1<44::AID-JNR5>3.0.CO;2-R     Document Type: Article

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