Relationship of p15 and p16 gene alterations to elevated dihydrofolate reductase in childhood acute lymphoblastic leukaemia

British Journal of Haematology

Volumn 113, Issue 3, 2001, Pages 746-756

  Shah, Sanjay J ^a   Taub, Jeffrey W ^a,b,c   Witt, Teah L ^a   Pollock, Brad H ^c   Ding, Bee Ching ^b   Moore, Daniel S ^a   Amylon, Michael ^c   Pullen, Jeanette ^c   Ravindranath, Yaddanapudi ^a,b,c   Matherly, Larry H ^a,b,c,d  

^a CHILDREN'S HOSPITAL OF MICHIGAN   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Pediatric Oncology Group   (United States)

^d KARMANOS CANCER INSTITUTE   (United States)

Author keywords

Acute lymphoblastic leukaemia; Dihydrofolate reductase; Methotrexate; p15; p16

Indexed keywords

COMPLEMENTARY DNA; DIHYDROFOLATE REDUCTASE; DOXYCYCLINE; METHOTREXATE; PROTEIN P15; PROTEIN P16; RETINOBLASTOMA PROTEIN; TETRACYCLINE; TRIMETREXATE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; CELL CYCLE S PHASE; CELL STRAIN K 562; CHILD; FEMALE; FLOW CYTOMETRY; GENE DELETION; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING;

ADOLESCENT; BLOTTING, SOUTHERN; CASE-CONTROL STUDIES; CELL CYCLE; CELL CYCLE PROTEINS; CHILD; CHILD, PRESCHOOL; CONFIDENCE INTERVALS; CYCLIN-DEPENDENT KINASE INHIBITOR P15; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXYCYCLINE; FEMALE; FLOW CYTOMETRY; GENE DELETION; GENE EXPRESSION; GENES, P16; HUMANS; INFANT; K562 CELLS; LEUKEMIA, B-CELL, ACUTE; LOGISTIC MODELS; MALE; ODDS RATIO; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TETRAHYDROFOLATE DEHYDROGENASE; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 0034989650     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2001.02775.x     Document Type: Article

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