Mucin-like glycoprotein genes are closely linked to members of the trans-sialidase super-family at multiple sites in the Trypanosoma cruzi genome

Molecular and Biochemical Parasitology

Volumn 78, Issue 1-2, 1996, Pages 127-136

  Salazar, Nelson A ^a   Mondragon, Angeles ^a   Kelly, John M ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Genetic linkage; Mucin; Trans sialidase; Trypanosoma cruzi

Indexed keywords

TRYPANOSOMA; TRYPANOSOMA CRUZI;

CELL SURFACE PROTEIN; DNA; GLYCOCONJUGATE; MUCIN LIKE GLYCOPROTEIN; SIALIC ACID; UNCLASSIFIED DRUG;

ARTICLE; DNA LIBRARY; ENZYME ASSAY; ENZYME BINDING; ENZYME MECHANISM; GENE ISOLATION; GENE LOCATION; GENETIC LINKAGE; PRIORITY JOURNAL; TRYPANOSOMA CRUZI;

EID: 0030008509     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(96)02617-5     Document Type: Article

References (42)

1. Schenkman, S., Eichinger, D., Pereira, M.E.A. and Nussenzweig, V. (1994) Structural and functional properties of Trypanosoma cruzi trans-sialidase. Annu. Rev. Microbiol. 48, 499-523.
2. Schenkman, S. and Eichinger, D. (1993) Trypanosoma cruzi trans-sialidase and cell invasion. Parasitol. Today 9, 218-222.
3. Colli, W. (1993) Trans-sialidase: a unique enzyme activity discovered in the protozoan Trypanosma cruzi. FASEB J. 7, 1257-1264.
4. Cross, G.A.M. and Takle, G.B. (1993) The surface transsialidase family of Trypanosoma cruzi. Annu. Rev. Microbiol. 46, 385-411.
5. Rosenberg, I., Prioli, R.P., Ortega-Barria, E. and Pereira, M.E.A. (1991) Stage-specific phospholipase C-mediated release of Trypanosoma cruzi neuraminidase. Mol. Biochem. Parasitol. 46, 303-306.
6. Vanderkerckhove, F., Schenkman, S., Pontes de Carvalho, L., Tomlinson, S., Kiso, M., Yoshida, M., Hasegawa, A. and Nussenzweig, V. (1992) Substrate specificity of the Trypanosoma cruzi trans-sialidase. Glycobiology 6, 541-548.
7. Scudder, P., Doom, J.P., Chuenkova, M., Manger, I.D. and Pereira, M.E.A. (1993) Enzymatic characterisation of the β-D-galactoside α2,3-trans-sialidase from Trypanosoma cruzi. J. Biol. Chem. 268, 9886-9891.
8. Schenkman, S., Jiang, M.-S., Hart, G.H. and Nussenzweig, V. (1991) A novel cell surface trans-sialidase of Trypanosoma cruzi generates a stage specific epitope required for invasion of mammalian cells. Cell, 65, 1117-1125.
9. Schenkman, S., Ferguson, M.A.J., Heise, N., Cardoso de Almeida, M.L., Mortara, R.A. and Yoshida, N. (1993) Mucin-like glycoproteins linked to the membrane by a glycosylphosphatidylinositol anchor are the major acceptors of sialic acid in a reaction catalysed by trans-sialidase in metacyclic forms of Trypanosoma cruzi. Mol. Biochem. Parasitol. 59, 293-304.
10. Yoshida, N., Mortara, R.A., Aragut, M.F., Gonzalez, J.C. and Russo, M. (1989) Metacyclic neutralising effect of monoclonal antibody 10D8 directed to the 35 and 50-kilodalton surface glycoconjugate of Trypanosoma cruzi. Infect. Immun. 57, 1663-1667.
11. Tomlinson, S., Pontes de Carvalho, L.C., Vanderkerckhove, F. and Nussenzweig, V. (1994) Role of sialic acid in resistance of Trypanosoma cruzi trypomastigotes to complement. J. Immunol. 153, 3141-3148.
12. Ming, M., Chuenkova, M., Ortega-Barria, E. and Pereira, M.E.A. (1993) Mediation of Trypanosoma cruzi invasion by sialic acid on the host cell and transsialidase on the trypanosomes. Mol. Biochem. Parasitol. 59, 243-252.
13. Schenkman, R.P.S., Vanderkerckhove, F. and Schenkman, S. (1993) Mammalian cell sialic acid enhances Trypanosoma cruzi invasion. Infect. Immun. 61, 898-902.
14. Hall, B.F., Webster, P., Ma, A.K., Joiner, K.A. and Andrews, N.W. (1992) Desialylation of lysosomal membrane glycoproteins by Trypanosoma cruzi: a role for surface neuraminidase facilitating parasite entry into the host cell cytoplasm. J. Exp. Med. 176, 313-325.
15. Chuenkova, M. and Pereira, M.E.A. (1995) Trypanosoma cruzi: enhancement of virulence in a murine model of Chagas' disease. J. Exp. Med. 181, 1693-1703.
16. Frasch, A.C.C. (1994) Trans-sialidase, SAPA amino acid repeats and the relationship between Trypanosoma cruzi and the mammalian host. Parasitology 108, S37-S44.
17. Uemura, H., Schenkman, S., Nussenzweig, V. and Eichinger, D. (1992) Only some members of a gene family in Trypanosoma cruzi encode proteins which express both trans-sialidase and neuraminidase. EMBO J. 11, 3837-3844.
18. Parodi, A.J., Pollevick, G.D., Mautner, M., Buschiazzo, A., Sanchez, D.O. and Frasch, A.C.C. (1992) Identification of the genes coding for the trans-sialidase of Trypanosoma cruzi. EMBO J. 11, 1705-1710.
19. Briones, M.R.S., Egima, C.M. and Schenkman, S. (1995) Trypanosoma cruzi trans-sialidase gene lacking C-terminal repeats and expressed in epimastigote forms. Mol. Biochem. Parasitol. 70, 9-17.
20. Van Voorhis, W.C. and Eisen, H. (1989) F1-160: A surface antigen of Trypanosoma cruzi that mimics mammalian nervous tissue. J. Exp. Med. 169, 641-652.
21. Van Voorhis, W.C., Schlekewy, L. and Le Trong, H. (1991) Molecular mimicry by Trypanosoma cruzi: the F1-160 epitope that mimics mammalian nerve can be mapped to a 12 amino acid peptide. Proc. Natl. Acad. Sci. USA 88, 5993-5997.
22. Takle, G.B., O'Connor, J., Young, A.J. and Cross, G.A.M. (1992) Sequence homology and absence of mRNA defines a possible pseudogene member of the Trypanosoma cruzi gp85/sialidase family. Mol. Biochem. Parasitol. 56, 117-128.
23. Campetella, O., Sanchez. D., Cazzulo, J.J. and Frasch, A.C.C. (1992) A superfamily of Trypanosoma cruzi surface antigens. Parasitol. Today 8, 378-381.
24. Peterson, D.S., Fouts, D.L. and Manning, J.E. (1989) The 85-kD surface antigen gene of Trypanosoma cruzi is telomeric and a member of a multigene family. EMBO J. 8, 3911-3916.
25. Kendall, G., Wilderspin, A.F., Ashall, F., Miles, M.A. and Kelly, J.M. (1990) Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase does not conform to the 'hotspot' topogenic signal model. EMBO J. 9, 2751-2758.
26. Kelly, J.M. (1993) Isolation of DNA and RNA from Leishmania. In: Protocols in Molecular Parasitology (Hyde, J.E., ed.), pp. 123-132. Humana Press, New Jersey, USA.
27. Kelly, J.M., Das, P. and Tomas, A.M. (1994) An approach to functional complementation by introduction of large DNA fragments into Trypanosoma cruzi and Leishmania donovani using a cosmid shuttle vector. Mol. Biochem. Parasitol. 65, 51-62.
28. Sambrook, J., Fritsch, E.F. and Maniatis, T. (1989) Molecular cloning: A laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
29. Bishop, R.P. and Miles, M.A. (1987) Chromosome size polymorphisms of Leishmania donovani. Mol. Biochem. Parasitol. 24, 263-272.
30. Reyes, M.B., Pollevick, G.D. and Frasch, A.C.C. (1994) An unusually small gene encodes a putative mucin-like glycoprotein in Trypanosoma cruzi. Gene 40, 139-140.
31. Pereira, M.E.A., Mejia, J.S., Ortega-Barria, E., Matzilevich, D. and Prioli, R.P. (1991) The Trypanosoma cruzi neuraminidase contains sequences similar to bacterial neuraminidases, YWTD repeats of the low density lipoprotein receptor, and type III modules of fibronectin. J. Exp. Med. 174, 179-191.
32. Jazin, E.E., Bontempi, E.J., Sanchez, D.O., Aslund, L., Henrikson, J., Frasch, A.C.C. and Pettersson, U. (1995) Trypanosoma cruzi exoantigen is a member of a 160 kDa gene family. Parasitology 110, 61-69.
33. Di Noia, J.M., Sachez, D.O. and Frasch, A.C.C. (1995) The protozoan Trypanosoma cruzi has a family of genes resembling the mucin genes of mammalian cells. J. Biol. Chem. 270, 24146-24149.
34. Englund, P.T. (1993) The structure and biosynthesis of glycosylphosphatidylinositol protein anchors. Annu. Rev. Biochem. 62, 121-138.
35. Almeida, I.C., Ferguson, M.A.J., Schenkman, S. and Travassos, L.R. (1994) Lytic anti-α-galactosyl antibodies from patients with chronic Chagas' disease recognise novel O-linked oligosaccharides on mucin-like glycosylphosphatidylinositol-anchored glycoproteins of Trypanosoma cruzi. Biochem. J. 304, 793-802.
36. Pereira-Chioccola, V.L., Franquini, J., Ribeirao, M., Rodrigues, M.M. and Schenkman, S. (1995) Can immunity to trans-sialidase and sialic acid acceptors control parasitism of Chagas' disease? Mem. Inst. Oswaldo Cruz 90, 11-12.
37. O'Connell, B.C., Tabak, L.A. and Ramasubbu, N. (1991) The influence of flanking sequences on O-glycosylation. B.B.R.C. 180, 1024-1030.
38. Wang, Y., Abernethy, J.L., Allen, E.E. and Hill, R.L. (1992) Purification and characterisation of a UDP-Gal-NAc:polypeptide N-acetylgalactosaminyl-transferase specific for threonine residues. J. Biol. Chem. 18, 12709-12716.
39. O'Connel, B.C., Hage, F.K. and Tabak, L.A. (1992) The influence of flanking sequence on the O-glycosylation of threonine in vitro. J. Biol. Chem. 267, 25010-25018.
40. Hansen, J.E., Lund, O., Engelbrecht, J., Bohr, H., Nielsen, J.O., Hansen, J.-E.S. and Brunak, S. (1995) Prediction of O-glycosylation of mammalian proteins: specificity patterns of UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase. Biochem. J. 308, 801-813.
41. Freitas Jr., L.H.G., Egima, C.M., Komninakis, S.C.V. and Schenkman, S. (1995) A highly repeated DNA sequence is present downstream of each group of trans-sialidase genes. Mem. Inst. Oswaldo Cruz 90, 112.
42. Le Blancq, S.M., Swinkels, B.W., Gibson, W.C. and Borst, P. (1988) Evidence of gene conversion between the phosphoglycerate kinase genes of Trypanosoma brucei. J. Mol. Biol. 200, 439-447.