Paradoxical interactions among estrogen receptors, estrogens and SERMS: Mutual annihilation and synergy

Journal of Steroid Biochemistry and Molecular Biology

Volumn 76, Issue 1-5, 2001, Pages 85-93

  Kaye, A M ^a   Spatz, M ^b   Waisman, A ^a   Sasson, S ^c   Tamir, S ^d   Vaya, J ^d   Somjen, D ^e  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b PHARMOS LTD   (Israel)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^d MIGAL GALILEE TECHNOLOGY CENTER   (Israel)

^e TEL AVIV UNIVERSITY   (Israel)

Author keywords

17 Estradiol; Antagonism; Creatine kinase B; Estrogens; SERMS

Indexed keywords

17ALPHA ESTRADIOL; CREATINE KINASE; CREATINE KINASE B; DAIDZEIN; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; FULVESTRANT; GENISTEIN; IODINE DERIVATIVE; LIGAND; MONOMER; QUERCETIN; RALOXIFENE; RESVERATROL; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; TAMOXIFEN METHIODIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; CELL STRAIN HEPG2; CELL STRAIN MCF 7; COMPETITIVE INHIBITION; CONFERENCE PAPER; CONFORMATION; CONTROLLED STUDY; DIAPHYSIS; ENZYME ACTIVITY; EPIPHYSIS; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; OSTEOSARCOMA CELL; PLASMID; PROTEIN PROTEIN INTERACTION; RAT; UTERUS;

ANTINEOPLASTIC AGENTS, HORMONAL; CREATINE KINASE; ESTROGENS; HUMANS; LIGANDS; NEOPLASMS; RECEPTORS, ESTROGEN; TAMOXIFEN; TRANSFECTION; TUMOR CELLS, CULTURED;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0034982234     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(00)00147-3     Document Type: Conference Paper

References (47)

1. Selective estrogen receptor modulators
2. Basic guide to the mechanism of antiestrogen action
3. Plasma levels of unconjugated estrone, estradiol and estriol and of HCS throughout pregnancy in normal women
4. The early history of estriol
5. Tamoxifen: The herald of a new era of preventive therapeutics
6. Lignans and phytoestrogens. Possible preventive role in cancer
7. Evolution, nutrition, intestinal microflora and prevention of cancer: A hypothesis
8. Tissue selective action of tamoxifen methiodide, raloxifene and tamoxifen on creatine kinase B activity in vitro and in vivo
9. An estrogen receptor paradox: Why do estrogen and tamoxifen antagonize each other's activity?
10. Enterolactone and estradiol inhibit each other's proliferative effect on MCF-7 breast cancer cells in culture
11. Molecular and kinetic basis for the mixed agonist/antagonist activity of estriol
12. Responsiveness of the 5′ flanking region of the brain type isozyme of creatine kinase to estrogens and antiestrogens
13. Effect of dietary components, including lignans and phyto-estrogens, on enterohepatic circulation and liver metabolism of estrogens and sex hormone binding globulin (SHBG)
14. Changes in the concentrations of dehydroepiandrosterone sulfate and estriol in maternal plasma during pregnancy: A longitudinal study in healthy women throughout gestation and term
15. Type II antagonists impair the DNA binding of steroid hormone receptors without affecting dimerization
16. Identification of the major component of the estrogen induced protein of rat uterus as the BB isozyme of creatine kinase
17. Estrogen-induced synthesis of a specific uterine protein
18. Delineation of sites mediating estrogen regulation of the rat creatine kinase B gene
19. A compound silencer region in the gene for creatine kinase B
20. Parathyroid hormone-responsive clonal cell lines from rat osteosarcoma
21. Direct and sex-specific stimulation by sex steroids of creatine kinase activity and DNA synthesis in rat bone
22. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
23. High efficiency gene transfer into mammalian cells
24. Firefly luciferase gene: Structure and expression in mammalian cells
25. A simple phase extraction assay for chloramphenical acetyl transferase activity
26. An improved CAT assay for promoter analysis in either transgenic mice or tissue culture cells
27. 2 and vitamin D metabolites
28. Stimulation of creatine kinase specific activity in human osteoblasts and endometrial cells by estrogens and antiestrogens and its modulation by calciotropic hormones
29. Raloxifene (LY 139481 HCl) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats
30. A permanently changed tamoxifen derivative displays improved activity and tissue selectivity in rodents
31. Non-hypercalcemic analogs of vitamin D stimulate creatine kinase B activity in osteoblast-like ROS 17/2.8 cells and upregulate their responsiveness to estrogens
32. Hormonal stimulation of bone cell proliferation
33. Resveratrol, a polyphenolic compound found in grapes and wine is an agonist for the estrogen receptor
34. Soy, its components and cancer prevention: A review of the in vitro, animal and human data
35. The two phyto-oestrogens genistein and quercetin exert different effects on oestrogen receptor function
36. Antioxidant constituents from licorice roots: Isolation, structure elucidation and antioxidant capacity towards LDL oxidation
37. Expression and regulation of estrogen receptor beta in human breast tumors and cell lines
38. The cloned human oestrogen receptor contains a mutation which alters its hormone binding properties
39. Induction properties of a transiently transfected glucocorticoid responsive gene vary with glucocorticoid receptor concentration
40. A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex
41. Estrogen receptor interaction with co-activators and co-repressors
42. Opposing effects of corepressors and coactivators in determining the dose-response curve of agonists and residual agonist activity of antagonists, for glucocortoid receptor-regulated gene expression
43. Purification and identification of p68 RNA helicase acting as transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha
44. An estrogen receptor-selective co-regulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogen
45. Molecular basis of agonism and antagonism in the oestrogen receptor
46. The estrogen receptor β isoform (ERβ) of the human estrogen receptor modulates ERα transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens
47. Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist