Differential sensitivity to the anxiolytic effects of ethanol and flunitrazepam in PKCγ null mutant mice

Pharmacology Biochemistry and Behavior

Volumn 69, Issue 1-2, 2001, Pages 99-110

  Bowers, Barbara J ^a   Elliott, Katherine J ^a   Wehner, Jeanne M ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Anxiety; Benzodiazepines; Ethanol; Genetics; Null mutant mice; PKC

Indexed keywords

ALCOHOL; ANXIOLYTIC AGENT; FLUNITRAZEPAM;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CONTROLLED STUDY; DEVICE; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG EFFICACY; DRUG RESPONSE; DRUG SENSITIVITY; FEMALE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPECIES DIFFERENCE; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; BEHAVIOR, ANIMAL; BRAIN CHEMISTRY; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FEMALE; FLUNITRAZEPAM; ISOENZYMES; MALE; MICE; MICE, KNOCKOUT; PROTEIN KINASE C;

EID: 0034979429     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(01)00510-X     Document Type: Article

References (50)

1. Modified hippocampal long-term potentiation in PKCγ-mutant mice
2. Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behavior and are hypersensitive to stress
3. Comparison of different behavioral test situations used in psychopharmacology for measurement of anxiety
4. Link between emotional memory and anxiety states: A study by principal component analysis
5. Decreased ethanol sensitivity and tolerance development in γ-protein kinase C null mutant mice is dependent on genetic background
6. Mice lacking PKCγ exhibit decreased anxiety
7. A genetic comparison of behavioral actions of ethanol and nicotine in the mirrored chamber
8. Anxiety- and activity-related effects of diazepam and chlordiazepoxide in the rat light/dark and dark/light tests
9. Abnormal fear response and aggressive behavior in mutant mice deficient for alpha-calcium-calmodulin kinase II
10. Neurogenetic adaptive mechanisms in alcoholism
11. Exploration of mice in a black and white test box: Validation as a model of anxiety
12. Response to diazepam in sons of alcoholics
13. Eye movement effects of diazepam in sons of alcoholic fathers and male control subjects
14. Genetic determinants of sensitivity to diazepam in inbred mice
15. Preliminary report of a simple animal behavioral model for the anxiolytic effects of benzodiazepines
16. A-receptor clustering results in enhanced anxiety and a bias for threat cues
17. Time course of ethanol's effects on locomotor activity, exploration and anxiety in mice
18. The effects of alcohol on anxiety in problem- and nonproblem-drinking women
19. Recent developments in anxiety, stress, and depression
20. Social interaction and elevated plus-maze tests: Changes in release and uptake of 5-HT and GABA
21. The therapeutic value, limitations and hazards of treatment of psychiatric disorders with benzodiazepines
22. Mirror-image stimulation
23. Differences in anxiety-related behaviors and in sensitivity to diazepam in inbred and outbred strains of mice
24. Mutant mice lacking the γ isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of γ-aminobutyrate type A receptors
25. 1A receptor mutant mice
26. A review of the validity and variability of the elevated plus-maze as an animal model of anxiety
27. Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase
28. Neurobiology and new psychopharmacological strategies for treatment of anxiety disorders
29. Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2
30. A receptor
31. A receptor specifically binds PKCγ: Effect of chronic ethanol consumption
32. The relation between alcohol problems and the anxiety disorders
33. The effects of alcohol consumption on laboratory induced panic and state anxiety
34. The use of a plus-maze to measure anxiety in the mouse
35. Ethologically-based animal models of anxiety disorders
36. Increased anxiety of mice lacking the serotonin 1A receptor
37. Stress and alcohol interaction: An update of human research
38. Possible role of protein kinase C in regulation of 5-hydroxytryptamine 2A receptors in rat brain
39. Serotonin receptor 1A knockout: An animal model of anxiety-related disorder
40. Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety
41. Benzodiazepine treatment of panic disorder
42. Risk for alcoholism and individual differences in the stress-response-dampening effect of alcohol
43. A receptors
44. Corticotropin releasing factor receptor deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development
45. Comparison of alcohol-preferring (P) and nonpreferring (NP) rats on tests of anxiety and for the anxiolytic effects of ethanol
46. The effects of ethanol and Ro 15-4513 on elevated plus-maze and rotarod performance in long-sleep and short-sleep mice
47. Ethanol and protein kinase C
48. Latency to enter a mirrored chamber: A novel behavioral assay for anxiolytic agents
49. A receptors requires phosphorylation of the alternatively spliced variant of the γ2 subunit
50. A receptor γ2L subunit in rat sensory neurons may not be necessary for ethanol sensitivity