Epstein-barr virus SM protein interacts with mRNA in vivo and mediates a gene-specific increase in cytoplasmic mRNA

Journal of Virology

Volumn 75, Issue 13, 2001, Pages 6033-6041

  Ruvolo, V ^a   Gupta, A K ^a   Swaminathan, S ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; NUCLEAR PROTEIN; PROTEIN SM; RIBONUCLEASE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; EPSTEIN BARR VIRUS; GENE ACTIVATION; GENE CONTROL; GENE DELETION; GENE EXPRESSION REGULATION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN RNA BINDING; REPORTER GENE; RNA PROCESSING; RNA STABILITY;

CYTOPLASM; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HERPESVIRUS 4, HUMAN; PHOSPHOPROTEINS; RNA, MESSENGER; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; VIRAL PROTEINS;

EID: 0034979001     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.13.6033-6041.2001     Document Type: Article

References (55)

1. The human herpesvirus-8 ORF 57 gene and its properties
2. Association with the cellular export receptor CRM 1 mediates function and intracellular localization of Epstein-Barr virus SM protein, a regulator of gene expression
3. A small element from the Mason-Pfizer monkey virus genome makes human immunodeficiency virus type 1 expression and replication Rev-independent
4. The C-terminal region but not the Arg-X-Pro repeat of Epstein-Barr virus protein EB2 is required for its effect on RNA splicing and transport
5. The Epstein-Barr Virus (EBV) early protein EB2 is a posttranscriptional activator expressed under the control of EBV transcription factors EB1 and R
6. The Epstein-Barr Virus (EBV) early promoter DR contains a cis-acting element responsive to the EBV transactivator EB1 and an enhancer with constitutive and inducible activities
7. Herpesviruses: A study of parts
8. Herpes simplex virus ICP27 induces cytoplasmic accumulation of unspliced polyadenylated alpha-globin pre-mRNA in infected HeLa cells
9. Both Epstein-Barr virus (EBV)-encoded trans-acting factors, EB1 and EB2, are required to activate transcription from an EBV early promoter
10. Localization of the coding region for an Epstein-Barr virus early antigen and inducible expression of this 60-kilodalton nuclear protein in transfected fibroblast cell lines
11. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction
12. Epstein-Barr virus SM protein
13. The gene product encoded by ORF 57 of herpesvirus saimiri regulates the redistribution of the splicing factor SC35
14. Genetic relations between varicellazoster virus and Epstein-Barr virus
15. Human growth hormone DNA sequence and mRNA structure: Possible alternative splicing
16. Processing of alpha-globin and ICPO mRNA in cells infected with herpes simplex virus type 1 ICP27 mutants
17. Epstein-Barr virus EB2 protein exports unspliced RNA via a Crm-1-independent pathway
18. Epstein-Barr virus genome
19. SV40-transformed simian cells support the replication of early SV40 mutants
20. The human herpesvirus 8 homolog of Epstein-Barr virus SM protein (KS-SM) is a posttranscriptional activator of gene expression
21. The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infection
22. Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effect
23. Arginine-rich regions succeeding the nuclear localization region of the herpes simplex virus type 1 regulatory protein ICP27 are required for efficient nuclear localization and late gene expression
24. A novel hepatitis B virus (HBV) genetic element with Rev response element-like properties that is essential for expression of HBV gene products
25. Intervening sequences increase efficiency of RNA 3′ processing and accumulation of cytoplasmic RNA
26. The mouse histone H2a gene contains a small element that facilitates cytoplasmic accumulation of intronless gene transcripts and of unspliced HIV-1-related mRNAs
27. Intronless mRNA transport elements may affect multiple steps of pre-mRNA processing
28. Role of the hepatitis B virus posttranscriptional regulatory element in export of intronless transcripts
29. Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm
30. The Epstein-Barr virus immediate-early gene product, BMLF1, acts in trans by a posttranscriptional mechanism which is reporter gene dependent
31. An Epstein-Barr virus immediate-early gene product trans-activates gene expression from the human immunodeficiency virus long terminal repeat
32. The Epstein-Barr virus (EBV) SM protein enhances pre-mRNA processing of the EBV DNA polymerase transcript
33. Kaposi's sarcoma-associated herpesvirus open reading frame 57 encodes a posttranscriptional regulator with multiple distinct activities
34. Pre-mRNA splicing alters mRNP composition: Evidence for stable association of proteins at exon-exon junctions
35. Promiscuous trans activation of gene expression by an Epstein-Barr virus-encoded early nuclear protein
36. HnRNP L binds a cis-acting RNA sequence element that enables intron-dependent gene expression
37. Splicing is required for rapid and efficient mRNA export in metazoans
38. The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNA
39. Disparate effects of two herpesviruses immediate-early gene trans-activators on the HIV LTR
40. The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1
41. The RGG box motif of the herpes simplex virus ICP27 protein mediates an RNA-binding activity and determines in vivo methylation
42. Identification of nuclear and nucleolar localization signals in the herpes simplex virus regulatory protein ICP27
43. Establishment and characterization of an Epstein-Barr virus (EBV)-negative lymphoblastoid B cell line (BJA-B) from an exceptional EBV-genome-negative African Burkitt's lymphoma
44. Varicella-zoster virus open reading frame 4 encodes a transcriptional activator that is functionally distinct from that of herpes simplex virus homolog ICP27
45. The Epstein-Barr virus nuclear protein SM is both a post-transcriptional inhibitor and activator of gene expression
46. Mapping of genes in BamHI fragment M of Epstein-Barr virus DNA that may determine the fate of viral infection
47. ICP27 mediates HSV RNA export by shuttling through a leucine-rich nuclear export signal and binding viral intronless RNAs through an RGG motif
48. The C-terminal repressor region of herpes simplex virus type 1 ICP27 is required for the redistribution of small nuclear ribonucleoprotein particles and splicing factor SC35; however, these alterations are not sufficient to inhibit host cell splicing
49. A herpesvirus regulatory protein appears to act post-transcriptionally by affecting mRNA processing
50. Mta has properties of an RNA export protein and increases cytoplasmic accumulation of Epstein-Barr virus replication gene mRNA
51. Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: Genomic complexity and molecular evolution of the gene
52. UL69 of human cytomegalovirus, an open reading frame with homology to ICP27 of herpes simplex virus, encodes a transactivator of gene expression
53. Identification and mapping of Epstein-Barr virus early antigens and demonstration of a viral gene activator that functions in trans
54. 3-acetyltransferase (SSAT) gene in human lung carcinoma cells
55. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans