Small proteins that modulate calmodulin-dependent signal transduction: Effects of pep- 19, neuromodulin, and neurogranin on enzyme activation and cellular homeostasis

Molecular Neurobiology

Volumn 22, Issue 1-3, 2001, Pages 99-113

  Randall Slemmon, J ^a   Feng, Bingbing ^a   Erhardt, Joseph A ^b  

^a SK Beecham Pharmaceut Res Devt   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Calcium signaling; Calmodulin; CAP 19; GAP 43; IQ motif; Mbf1; Neurogranin; Neuromodulin; PEP 19; RC3; Regulation

Indexed keywords

BRAIN PROTEIN; CALCIUM; CALMODULIN; CALMODULIN BINDING PROTEIN; CALMODULIN BINDING PROTEIN CAP 19; CALMODULIN INHIBITOR; NEUROGRANIN; NEUROMODULIN; PROTEIN PEP 19; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; ENZYME ACTIVATION; INHIBITION KINETICS; MOLECULAR INTERACTION; NEUROMODULATION; NEUROTOXICITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0034976714     PISSN: 08937648     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (66)

1. Calcium signaling in neurons: Molecular mechanisms and cellular consequences
2. Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons
3. Sensitivity of CaM Kinase II to the frequency of Ca2+ oscillations
4. The role of Ca2+ in cell injury, necrosis and apoptosis
5. Glutamate, immediate-early genes, and cell death in the nervous system
6. Memories of fos
7. CREB phosphorylation and dephosphorylation: A Ca2+- and stimulus duration-dependent switch for hippocampal gene expression
8. Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation
9. Quantitative determinations of calmodulin in the supernatant and particulate fractions of mammalian tissues
10. Calmodulin
11. Regulation of free calmodulin levels by neuromodulin: Neuron growth and regeneration
12. Phosphorylation-dependent binding of a synthetic MARCKS peptide to calmodulin
13. Mutational and biophysical studies suggest RC3/neurogranin regulates calmodulin availability
14. Dependence of calmodulin localization in the retina on the NINAC unconventional myosin
15. The activity of calmodulin is altered by phosphorylation: Modulation of calmodulin function by the site of phosphate incorporation
16. Phosphorylation of calmodulin alters its potency as an activator of target enzymes
17. The relationship between the free concentrations of Ca2+ and Ca2+-calmodulin in intact cells
18. Axonal growth-associated proteins
19. B-50 (GAP-43): Biochemistry and functional neurochemistry of a neuron-specific phosphoprotein
20. RC3/neurogranin, a postsynaptic calpacitin for setting the response threshold to calcium influxes
21. Isolation, sequence, and developmental profile of a brain-specific polypeptide, PEP-19
22. Cerebellar Purkinje cell markers are expressed in retinal bipolar neurons
23. PEP-19 immunohistochemistry defines the basal ganglia and associated structures in the adult human brain, and is dramatically reduced in Huntington's disease
24. Distribution and targets of the cartwheel cell axon in the dorsal cochlear nucleus of the guinea pig
25. PEP-19 immunoreactivity in the cochlear nucleus and superior olive of the cat
26. Molecular cloning of a neuron-specific transcript and its regulation during normal and aberrant cerebellar development
27. Peptide 19 in the dorsal root ganglion and the mesencephalic trigeminal tract nucleus of the adult rat
28. Peptide 19-immunoreactive primary sensory neurons in the rat trigeminal ganglion
29. Structure and regulation of the gene encoding the neuron-specific protein PEP-19
30. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
31. Increased levels of hemoglobin-derived ad other peptides in Alzheimer's disease cerebellum
32. Dicing with death: Dissecting the components of the apoptosis machinery
33. Neuroprotective effects of gangliosides may involve inhibition o nitric oxide synthase
34. Expansion of polyglutamine repeat in huntingtin leads to abnormal protein interactions involving calmodulin
35. Identification of a neuronal calmodulin-binding peptide, CAP-19, containing an IQ motif
36. Neuromodulin (GAP-43) can regulate a calmodulin-dependent target in vitro
37. The dendritic peptide neurogranin can regulate a calmodulin-dependent target
38. Primary structure and cellular localization of chicken brain myosin-V (p190), an unconventional myosin with calmodulin light chains
39. Camstatins are peptide antagonists of calmodulin based upon a conserved structural motif in PEP-19, neurogranin, and neuromodulin
40. Identification of the protein kinase C phosphorylation site in neuromodulin
41. Purification and characterization of a brain-specific protein kinase C substrate, neurogranin (p17)
42. Regulation of calmodulin binding to P57
43. Dephosphorylation of neuromodulin by calcineurin
44. Posttranslational membrane attachment and dynamic fatty acylation of a neuronal growth cone protein, GAP-43
45. The neuronal-associated protein GAP-43 induces filopodia in non-neuronal cells
46. Targeting of neuromodulin (GAP-43) fusion proteins to growth cones in cultured rat embryonic neurons
47. Palmitoylation alters protein activity: Blockade of Go stimulation by GAP-43
48. GAP-43 augments G protein-coupled receptor transduction in Xenopus laevis oocytes
49. The distribution of nitric oxide synthase immunoreactivity in the human brain
50. Cerebellar injury induces NOS in Purkinje cells in cerebellar afferent neurons
51. Isolation of nitric oxide synthase, a calmodulin-requiring enzyme
52. Calmodulin-binding peptide PEP-19 modulates activation of calmodulin kinase II in situ
53. Isolation of phosphorylated calmodulin from rat liver and identification of the in vivo phosphorylation sites
54. Phosphorylation of calmodulin by plasma-membrane-associated protein kinase(s)
55. Identification of insulin-stimulated phosphorylation sites on calmodulin
56. Phosphorylation of calmodulin by permeabilized fibroblasts overexpressing the human epidermal growth factor receptor
57. Expression of PEP-19 inhibits apoptosis in PC12 cells
58. Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells
59. Calcium and reactive oxygen species in staurosporine-induced neuronal apoptosis
60. Multiple bridging factor 1 (MBF1) is an evolutionarily conserved transciptional coactivator that connects a regulatory factor TATA element-binding protein
61. The role of human MBF1 as a transcriptional coactivator
62. Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo
63. EDF-1, a novel gene product down-regulated in human endothelial cell differentiation
64. Concerted regulation of protein phosphorylation and dephosphorylation by calmodulin
65. 2+/calmodulin-dependent protein kinase II
66. Calmodulin trapping by calcium-calmodulin-dependent protein kinase