Fate of intravenously administered squalene and plant sterols in human subjects

Journal of Lipid Research

Volumn 42, Issue 6, 2001, Pages 988-994

  Relas, H ^a   Gylling, H ^a   Miettinen, T A ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Campesterol; Cholesteryl esters; Chylomicrons; Intralipid; Sitosterol; Stigmasterol; Triglycerides

Indexed keywords

CAMPESTEROL; CHOLESTEROL; CHYLOMICRON; INTRALIPID; PHYTOSTEROL; SITOSTEROL; SQUALENE; STIGMASTEROL; TRIACYLGLYCEROL;

ADULT; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; DRUG HALF LIFE; FATTY ACID METABOLISM; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL;

ADULT; ANTILIPEMIC AGENTS; CHOLESTEROL; HUMANS; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL; MALE; MIDDLE AGED; PHYTOSTEROLS; POSTPRANDIAL PERIOD; SITOSTEROLS; SQUALENE; STIGMASTEROL; TIME FACTORS; TRIGLYCERIDES;

EID: 0034974466     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Heterogeneity of apolipoprotein B: Isolation of a new species from human chylomicrons
2. Delayed clearance of chylomicron remnants following vitamin-A-containing oral fat loads in broad-β disease (type III hyperlipoproteinemia)
3. Postabsorptive metabolism of dietary squalene
4. A methodological study of an intravenous fat tolerance test with Intralipid® emulsion
5. Plasma kinetics of a chylomicron-like emulsion in patients with coronary artery disease
6. Effect of pravastatin on plasma removal of a chylomicron-like emulsion in men with coronary artery disease
7. Inborn errors in bile acid biosynthesis and storage of sterols other than cholesterol
8. Phytosterolemia
9. Redistribution of cholesterol and β-sitosterol between Intralipid and rat plasma lipoproteins and red blood cells in vivo
10. Features of cholesterol structure that regulate the clearance of chylomicron-like lipid emulsions
11. Impaired postprandial clearance of squalene and apolipoprotein B-48 in post-menopausal women with coronary artery disease
12. Squalene in human and rat blood plasma
13. Measurement of cholesterol synthesis in man by isotope kinetics of squalene
14. Fate of intravenously administered squalene in the rat
15. A rapid micromethod for apolipoprotein E phenotyping directly in serum
16. Quantitation of lipoproteins
17. Non-cholesterol sterols and bile acid production in hypercholesterolaemic patients with ileal bypass
18. Cholesterol metabolism during ketoconazole treatment in man
19. Remnant lipoprotein metabolism: Key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E
20. ApoE is necessary and sufficient for the binding of large triglyceride-rich lipoproteins to the LDL receptor; apoB is unnecessary
21. Metabolism of protein-free lipid emulsion models of chylomicrons in rats
22. Cholesterol is necessary for triacylglycerol-phospholipid emulsions to mimic the metabolism of lipoproteins
23. Intravenous lipid emulsions: Removal mechanisms as compared with chylomicrons
24. Studies on the elimination of exogenous lipids from the blood stream. The kinetics for the elimination of chylomicrons studied by single intravenous injections in man
25. Studies on the fat emulsion Intralipid®. I. Association of serum proteins to Intralipid® triglyceride particles (ITP)
26. Release of lipoprotein lipase to plasma by triacylglycerol emulsions. Comparison to the effect of heparin
27. Distribution of lipoprotein lipase and hepatic lipase between plasma and tissues: Effect of hypertriglyceridemia
28. Acute and chronic effects of a 24-hour intravenous triglyceride emulsion challenge on plasma lecithin:cholesterol acyltransferase, phospholipid transfer protein, and cholesteryl ester transfer protein activities
29. Metabolism of triglyceride-rich lipoproteins during alimentary lipemia
30. Relationships between the responses of triglyceride-rich lipoproteins in blood plasma containing apolipoproteins B-48 and B-100 to a fat-containing meal in normolipidemic humans
31. Accumulation of large very low density lipoprotein in plasma during intravenous infusion of a chylomicron-like triglyceride emulsion reflects competition for a common lipolytic pathway
32. The fate of intravenously administered radioactive cholesterol dispersion in the rat
33. Particle size determines the specificity of apolipoprotein E-containing triglyceride-rich emulsions for the LDL receptor versus hepatic remnant receptor in vivo
34. Clearance from plasma of triacylglycerol and cholesteryl ester after intravenous injection of chylomicron-like lipid emulsions in rats and man
35. Receptor-mediated mechanisms of lipoprotein remnant catabolism
36. The plasma lecithin:cholesterol acyltransferase reaction
37. Substrate specificity of lecithin:cholesterol acyltransferase. Esterification of desmosterol, β-sitosterol, and cholecalciferol in human plasma
38. Plasma lipid transfer proteins
39. Isolation and characterization of a phospholipid transfer protein (LTP-II) from human plasma
40. Molecular and macromolecular specificity of human plasma phospholipid transfer protein
41. Phospholipid transfer protein mediates transfer of not only phosphatidylcholine but also cholesterol from phosphatidylcholine-cholesterol vesicles to high density lipoproteins
42. Thermodynamic and molecular determinants of sterol solubilities in bile salt micelles
43. Metabolism of β-sitosterol in man
44. Comparison of intestinal absorption of cholesterol with different plant sterols in man
45. Serum plant sterols and cholesterol precursors reflect cholesterol absorption and synthesis in volunteers of a randomly selected male population