Pathogenesis of type 2 diabetes mellitus

Experimental and Clinical Endocrinology and Diabetes

Volumn 109, Issue SUPPL. 2, 2001, Pages

  Dostou, J ^a   Gerich, J ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Beta cell dysfunction; Insulin resistance

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; INSULIN; METFORMIN; SULFONYLUREA DERIVATIVE;

ARTICLE; GENETICS; GLUCOSE METABOLISM; HUMAN; HYPERGLYCEMIA; INSULIN RELEASE; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL;

DIABETES MELLITUS, TYPE 2; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERGLYCEMIA; INSULIN; INSULIN RESISTANCE; POSTPRANDIAL PERIOD;

EID: 0034973156     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2001-18577     Document Type: Article

References (69)

1. Role of hyperglucagonemia in maintenance of increased rates of hepatic glucose output in type II diabetics
2. Assessment of the postprandial pattern of glucose metabolism in nondiabetic subjects and patients with noninsulin-dependent diabetes mellitus using a simultaneous infusion of [2-3H] and [3-3H]-glucose
3. Impaired physical fitness and insulin secretion in normoglycaemic subjects with familial aggregation of type II diabetes mellitus
4. The early serum insulin response to intravenous glucose in patients with decreased glucose tolerance and in subjects with a familial history of diabetes
5. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
6. Elevated serum human growth hormone and decreased serum insulin in prediabetic males after intravenous tolbutamide and glucose
7. Contribution to postprandial hyperglycemia and effect on initial splanchnic glucose clearance of hepatic glucose cycling in glucose-intolerant or NIDDM patients
8. Loss of early phase of insulin release in humans impairs glucose tolerance and blunts thermic effect of glucose
9. Plasma-insulin response to sustained hyperglycemia induced by glucose infusion in human subjects
10. "What is inherited - What is added" hypothesis for the pathogenesis of diabetes mellitus
11. Mechanism of increased gluconeogenesis in noninsulin dependent diabetes mellitus: Role of alterations in systemic, hepatic and muscle lactate and alanine metabolism
12. Untersuchungen des Kohlenhydrat und Fettstoffwechsels bei Prädiabetes
13. The triumvirate: B-cell, muscle, and liver: A collusion responsible for NIDDM
14. Insulin resistance: A multifaceted syndrome response for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease
15. Fasting hyperglycemia in noninsulin-dependent diabetes mellitus: Contributions of excessive hepatic glucose production and impaired tissue glucose uptake
16. Hepatic and peripheral insulin resistance: A common feature of type II (noninsulin-dependent) and type I (insulin-dependent) diabetes mellitus
17. Carbohydrate metabolism in noninsulin-dependent diabetes mellitus
18. Beta-cell dysfunction in first-degree relatives of patients with non-insulin-dependent diabetes mellitus
19. The disposal of an oral glucose load in patients with noninsulin-dependent diabetes
20. The role of fractional glucose extraction in the regulation of splanchnic glucose metabolism in normal and diabetic man
21. Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus. Role of hepatic and extrahepatic tissues
22. Metabolic abnormalities in impaired glucose tolerance
23. The genetic basis of type 2 diabetes mellitus: Impaired insulin secretion versus impaired insulin sensitivity
24. Insulin resistance versus impaired insulin secretion as the genetic basis for type 2 diabetes
25. Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus
26. Genetic regulation of the kinetics of glucose-induced insulin release in man
27. Forearm glucose uptake during the oral glucose tolerance test in normal subjects
28. A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA
29. Diabetes mellitus and its vascular complications in Japanese migrants on the Island of Hawaii
30. Impaired postprandial glucose utilization in non-insulin-dependent diabetes mellitus
31. Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus
32. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
33. Trends in the prevalence and incidence of diabetes: Non-insulin-dependent diabetes mellitus
34. Diabetes mellitus in the Pima Indians: Incidence, risk factors and pathogenesis
35. Diabetes incidence in Pima indians: Contributions of obesity and parental diabetes
36. Gm3;5,13,14 and type 2 diabetes mellitus: An association in American Indians with genetic admixture
37. Heterogenous glycemic and insulinemic responses to oral glucose in nondiabetic men: Interactions between duration of obesity, body fat distribution and family history of diabetes mellitus
38. Evidence for decreased splanchnic glucose uptake after oral glucose administration in non-insulin-dependent diabetes mellitus
39. Increased rate of gluconeogenesis in type II diabetes. A 13C nuclear magnetic resonance study
40. A prospective study of exercise and incidence of diabetes among US male physicians
41. Physical activity and incidence of non-insulin-dependent diabetes mellitus in women
42. Role of glucose and insulin resistance in development of type II diabetes mellitus: Results of a 25-year follow-up study
43. Effects of basal insulin supplementation on disposition of a mixed meal in obese patients with NIDDM
44. Effects of physiological hyperinsulinemia on systemic, renal and hepatic substrate metabolism
45. Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus
46. Role of reduced suppression of glucose production and diminished early insulin release in impaired glucose tolerance
47. Contribution of abnormal muscle and liver glucose metabolism in postprandial hyperglycemia in noninsulin-dependent diabetes mellitus
48. Concordance in type II (noninsulin-dependent) diabetes mellitus in male twins
49. Increased lipolysis and its consequences on gluconeogenesis in noninsulin-dependent diabetes mellitus
50. Insulin resistance in relatives of NIDDM patients: The role of physical fitness and muscle metabolism
51. Impaired pulsatile secretion of insulin in relatives of patients with noninsulin-dependent diabetes
52. Glucose tolerance and insulin response to glucose in two large families with diabetic mothers in the first generation
53. Evidence of increased systemic glucose production and gluconeogenesis in an early stage of NIDDM
54. Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM
55. Insulin sensitivity of forearm tissues in prediabetic man
56. Effects of a traditional lifestyle on obesity in Pima Indians
57. Offspring of two diabetic parents: Differential serum insulin responses to intravenous glucose and tolbutamide
58. Levels of plasma insulin during cortisone glucose tolerance tests in "nondiabetic" relatives of diabetic patients: Implications of diminished insulin secretory reserve in subclinical diabetes
59. A two-step model for development of noninsulin dependent diabetes
60. Disorderly and nonstationary insulin secretion in relatives of patients with NIDDM
61. Studies in prediabetes insulin response to oral glucose intravenous tolbutamide and rapid intravenous glucose infusion in genetic prediabetes
62. Early phase of insulin release
63. Uptake and release of glucose by the human kidney: Postabsorptive rates and responses to epinephrine
64. Glutamine and alanine metabolism in NIDDM
65. Insulin secretion, insulin action, and hepatic glucose production in identical twins discordant for non-insulin-dependent diabetes mellitus
66. Insulin secretion in normal glucose-tolerant relatives of type 2 diabetic subjects: Assessments using hyperglycemic glucose clamps and oral glucose tolerance tests
67. Monogenic diabetes mellitus in youth. The MODY syndromes
68. The NIDDM epidemic: Global estimates and projections - A look into the crystal ball