Agonist activity of the δ-antagonists TIPP and TIPP-ψ in cellular models expressing endogenous or transfected δ-opioid receptors

Journal of Pharmacology and Experimental Therapeutics

Volumn 298, Issue 1, 2001, Pages 240-248

  Martin, Nancy A ^a   Terruso, Maguerite T ^a   Prather, Paul L ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; ENKEPHALIN DERIVATIVE; GUANINE NUCLEOTIDE BINDING PROTEIN; N TYROSINYL(1,2,3,4 TETRAHYDROISOQUINOLINE)PHENYLALANYLPHENYLALANINE; N,N DIALLYLTYROSYL 2 METHYLALANYL 2 METHYLALANYLPHENYLALANYLLEUCINE; NALOXONE; NALTRIBEN; OPIATE ANTAGONIST; PEPTIDE DERIVATIVE; PERTUSSIS TOXIN; SIGMA OPIATE RECEPTOR; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY;

ADENYLATE CYCLASE; ANALGESICS, OPIOID; ANIMALS; CELL LINE; CRICETINAE; CYCLIC AMP; DIPRENORPHINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENKEPHALIN, D-PENICILLAMINE (2,5)-; HUMANS; NARCOTIC ANTAGONISTS; OLIGOPEPTIDES; RECEPTORS, OPIOID, DELTA; TETRAHYDROISOQUINOLINES;

EID: 0034972526     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice
2. A separation method for the assay of adenylylcyclase, intracellular cyclic AMP, and cyclic-AMP phosphodiesterase using tritium-labeled substrates
3. Role of aromatic transmembrane residues of the delta-opioid receptor in ligand recognition
4. Constitutive activation of the delta opioid receptor by mutations in transmembrane domains III and VII
5. Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
6. Selectivities of opioid peptide analogues as agonists and antagonists at the delta-receptor
7. ICI 174864: A highly selective antagonist for the opioid delta-receptor
8. Attenuation of morphine tolerance and dependence with the highly selective delta-opioid receptor antagonist TIPP-ψ
9. Antinociceptive profile of biphalin, a dimeric enkephalin analog
10. Visualization of time-dependent redistribution of delta-opioid receptors in neuronal cells during prolonged agonist exposure
11. Relationship between kappa 1 opioid receptor binding and inhibition of adenylyl cyclase in guinea pig brain membranes
12. Inverse agonism by dmt-Tic analogues and HS 378, a naltrindole analogue
13. Opiate receptor down-regulation and desensitization in neuroblastoma X glioma NG108-15 hybrid cells are two separate cellular adaptation processes
14. Opiate regulation of adenosine 3′:5′-cyclic monophosphate level in neuroblastoma X glioma NG108-15 hybrid cells. Relationship between receptor occupancy and effect
15. Molecular mechanisms and regulation of opioid receptor signaling
16. Protein measurement with the Folin phenol reagent
17. Spontaneous degradation via diketopiperazine formation of peptides containing a tetrahydroisoquinoline-3-carboxylic acid residue in the 2-position of the peptide sequence
18. Interaction of co-expressed mu- and delta-opioid receptors in transfected rat pituitary GH3 cells
19. Delta-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2
20. Involvement of delta 2 opioid receptors in the development of morphine dependence in mice
21. Analysis of inverse agonism at the delta opioid receptor after expression in Rat 1 fibroblasts
22. Constitutive activity of the delta-opioid receptor expressed in C6 glioma cells: Identification of non-peptide delta-inverse agonists
23. 3 cells
24. Naltrindole, a highly selective and potent non-peptide delta opioid receptor antagonist
25. Interaction of delta-opioid receptors with multiple G proteins: A non-relationship between agonist potency to inhibit adenylyl cyclase and to activate G proteins
26. Delta-opioid receptors are more efficiently coupled to adenylyl cyclase than to L-type Ca2+ channels in transfected rat pituitary cells
27. The delta-opioid receptor: Molecular pharmacology, signal transduction, and the determination of drug efficacy
28. Factors determining specificity of signal transduction by G-protein-coupled receptors. Regulation of signal transfer from receptor to G-protein
29. Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: Development of a class of potent and highly delta-selective peptide antagonists
30. The TIPP opioid peptide family: Development of delta antagonists, delta agonists, and mixed mu agonist/delta antagonists
31. TIPP-ψ: A highly potent and stable pseudopeptide delta opioid receptor antagonist with extraordinary delta selectivity
32. Subtleties of structure-agonist versus antagonist relationships of opioid peptides and peptidomimetics
33. G proteins and opioid receptor-mediated signalling
34. Antinociception after intracerebroventricular administration of naltrindole in the mouse
35. Interaction of clonidine and clonidine analogs with human platelet alpha 2-adrenergic receptors
36. Inhibition of calcium currents by noradrenaline, somatostatin and opioids in guinea-pig submucosal neurones
37. 35S]thio)triphosphate to NG108-15 cell membranes: Characterization of agonist and inverse agonist effects
38. Statistical analysis of drug-drug and site-site interactions with isobolograms
39. Side chain methyl substitution in the delta-opioid receptor antagonist TIPP has an important effect on the activity profile
40. Involvement of Trp-284, Val-296, and Val-297 of the human delta-opioid receptor in binding of delta-selective ligands
41. TIPP-ψ, a highly selective delta ligand
42. Influence of G protein type on agonist efficacy