Msx1 is present in thyrotropic cells and binds to a consensus site on the glycoprotein hormone α-subunit promoter

Molecular Endocrinology

Volumn 11, Issue 12, 1997, Pages 1782-1794

  Sarapura, Virginia D ^a   Strouth, Heidi L ^a   Gordon, David F ^a   Wood, William M ^a   Ridgway, E Chester ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GLYCOPROTEIN; HOMEODOMAIN PROTEIN; PROTEIN SUBUNIT; TRANSCRIPTION FACTOR;

ALPHA CHAIN; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CRANIOFACIAL DEVELOPMENT; GENE EXPRESSION; HYPOPHYSIS CELL; LIMB BUD; LIMB DEVELOPMENT; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; THYROTROPIN RELEASE;

ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE; CLONING, MOLECULAR; CONSENSUS SEQUENCE; DEOXYRIBONUCLEASE I; DNA, COMPLEMENTARY; GENE LIBRARY; GLYCOPROTEIN HORMONES, ALPHA SUBUNIT; HOMEODOMAIN PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MSX1 TRANSCRIPTION FACTOR; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS (GENETICS); REPETITIVE SEQUENCES, NUCLEIC ACID; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0030716496     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.11.12.1782     Document Type: Article

References (74)

1. Sarapura VD, Wood WM, Gordon DF, Ocran KW, Kao MY, Ridgway EC 1990 Thyrotrope expression and thyroid hormone inhibition map to different regions of the mouse glycoprotein hormone α-subunit promoter. Endocrinology 127:1352-1361
2. Hamernik DL, Keri RA, Clay CM, Clay JN, Sherman GB, Hawyer HRJ, Nett TM, Nilson JH 1992 Gonadotrope and thyrotrope specific expression of the human and bovine glycoprotein hormone a subunit genes is regulated by distinct cis-acting elements. Mol Endocrinol 6:1745-1755
3. Bokar JA, Keri RA, Farmerie TA, Fenstermaker RA, Andersen B, Hamernik DL, Yun J, Wagner T, Nilson JH 1989 Expression of the glycoprotein hormone α-subunit gene in the placenta requires a functional cyclic AMP response element, whereas a different cis-acting element mediates pituitary-specific expression. Mol Cell Biol 9:5113-5122
4. Kendall SK, Saunders TL, Jin L, Lloyd RV, Glode LM, Nett TM, Keri RA, Nilson JH, Camper SA 1991 Targeted ablation of pituitary gonadotropes in transgenic mice. Mol Endocrinol 5:2025-2036
5. Delegeane AM, Ferland LH, Mellon PL 1987 Tissue-specific enhancer of the human glycoprotein α-subunit gene: dependence on cyclic AMP-inducible elements. Mol Cell Biol 7:3994-4002
6. Steger DJ, Altschmied J, Buscher M, Mellon P 1991 Evolution of placenta-specific gene expression: comparison of the equine and human gonadotropin α-subunit genes. Mol Endocrinol 5:243-255
7. Fenstermaker RA, Farmerie TA, Clay CM, Hamernik DL, Nilson JH 1990 Different combinations of regulatory elements may account for expression of the glycoprotein hormone α-subunit gene in primate and horse placenta. Mol Endocrinol 4:1480-1487
8. Jameson JL, Deutsch PJ, Gallagher GD, Jaffe RC, Habener JF 1987 Trans-acting factors interact with a cyclic AMP response element to modulate expression of the human gonadotropin α gene. Mol Cell Biol 7:3032-3040
9. Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF 1988 Cyclic-AMP responsive DMA-binding protein structure based on a cloned placental cDNA. Science 242:1430-1432
10. Jameson JL, Albanese C, Habener JF 1989 Distinct adjacent protein-binding domains in the glycoprotein hormone a gene interact independently with a cAMP-responsive enhancer. J Biol Chem 264:16190-16196
11. Barnhart KM, Mellon PM 1994 The orphan nuclear receptor, steroidogenic factor-1, regulates the glycoprotein hormone α-subunit gene in pituitary gonadotropes. Mol Endocrinol 8:878-885
12. Bach I, Rhodes SJ, Pearse IIRV, Heinzel T, Gloss B, Scully KM, Sawchenko PE, Rosenfeld MG 1995 P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1. Proc Natl Acad Sci USA 92:2720-2724
13. Roberson MS, Schoderbek WE, Tremml G, Maurer RA 1994 Activation of the glycoprotein hormone α-subunit promoter by a LIM-homeodomain transcription factor. Mol Cell Biol 14:2985-2993
14. Lamonerie T, Tremblay JJ, Lanctot C, Therrien M, Gauthier Y, Drouin J 1996 Ptx1, a bicoid-related homeo box transcription factor involved in transcription of the pro-opiomelanocortin gene. Genes Dev 10:1284-1295
15. Szeto DP, Ryan AK, O'Connell SM, Rosenfeld MG 1996 P-otx: a Pit-1 interacting homeodomain factor expressed during anterior pituitary development. Proc Natl Acad Sci USA 93:7706-7710
16. Ross DS, Downing MF, Chin WW, Kieffer JD, Ridgway EC 1983 Changes in tissue concentrations of thyrotropin, free thyrotropin-β, and α-subunits after thyroxine administration: comparison of mouse hypothyroid pituitary and thyrotropic tumors. Endocrinology 112:2050-2053
17. Shupnik MA, Chin WW, Ross DS, Downing MF, Habener JF, Ridgway EC 1983 Regulation by thyroxine of the mRNA encoding the a subunit of mouse thyrotropin. J Biol Chem 258:15120-15124
18. Chin WW, Shupnik MA, Ross DS, Habener JF, Ridgway EC 1985 Regulation of the a and thyrotropin β-subunit messenger ribonucleic acids by thyroid hormones. Endocrinology 116:873-878
19. Shupnik MA, Ridgway EC 1985 Triiodothyronine rapidly decreases transcription of the thyrotropin subunit genes in thyrotropic tumor explants. Endocrinology 117:1940-1946
20. Akerblom IE, Ridgway EC, Mellon PL 1990 An α-subunit secreting cell line derived from a mouse pituitary tumor. Mol Endocrinol 4:589-596
21. Ridgway EC, Kieffer JD, Ross DS, Downing M, Mover H, Chin WW 1983 Mouse pituitary tumor line secreting only the α-subunit of the glycoprotein hormones: development from a thyrotropic tumor. Endocrinology 113:1587-1591
22. Robert B, Sassoon D, Jacq B, Gehring W, Buckingham M 1989 Hox-7, a mouse homeobox gene with a novel pattern of expression during embryogenesis. EMBO J 8:91-100
23. Hill RE, Jones PF, Rees AR, Sime CM, Justice MJ, Copeland NG, Jenkins NA, Graham E, Davidson DR 1989 A new family of mouse homeobox-containing genes: molecular structure, chromosomal location, and developmental expression of Hox-7.1. Genes Dev 3:26-37
24. MacKenzie A, Ferguson MWJ, Sharpe PT 1991 Hox-7 expression during murine craniofacial development. Development 113:601-611
25. MacKenzie A, Leeming GL, Jowett AK, Ferguson MWJ, Sharpe PT 1991 The homeobox gene Hox 7.1 has specific regional and temporal expression patterns during early murine craniofacial embryogenesis, specially tooth development in vivo and in vitro. Development 111:269-285
26. Pavlova A, Boutin E, Cunha G, Sassoon D 1994 Msx1 (Hox-7.1) in the adult mouse uterus: cellular interactions underlying regulation of expression. Development 120:335-346
27. Phippard DJ, Weber-Hall SJ, Sharpe PT, Naylor MS, Jayatalake H, Maas R, Woo I, Roberts-Clark D, Francis-West PH, Liu Y-H, Maxson R, Hill. RE, Dale TC 1996 Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development. Development 122:2729-2737
28. Friedman Y, Daniel CW 1996 Regulated expression of homeobox genes Msx-1 and Msx-2 in mouse mammary gland development suggests a role in hormone action and epithelial-stromal interactions. Dev Biol 177:347-355
29. Shang Z, Ebright YW, Her N, Pendergrast PS, Echelard Y, McMahon AP, Ebright RH, Abate C 1994 DNA affinity cleaving analysis of homeodomain-DNA interaction: identification of homeodomain consensus sites in genomic DNA. Proc Natl Acad Sci USA 91:118-122
30. Kuzuoka M, Takahashi T, Guron C, Raghow R 1994 Murine homeobox-containing gene, Msx1: analysis of genomic organization, promoter structure, and potential autoregulatory cis-acting elements. Genomics 21:85-91
31. Monaghan AP, Davidson DR, Sime C, Graham E, Baldock R, Bhattacharya SS, Hill RE 1991 The Msh-like homeobox genes define domains in the developing vertebrate eye. Development 112:1053-1061
32. Holland P 1991 Cloning and evolutionary analysis of msh-like homeobox genes from mouse, zebrafish and ascidian. Gene 98:253-257
33. Bell JR, Noveen A, Liu YH, Ma L, Dobias S, Kundu R, Luo W, Xia Y, Lusis AJ, Snead ML, Maxson R 1993 Genomic structure, chromosomal localization, and evolution of the mouse Hox 8 gene. Genomics 16:123-131
34. Hoffmann HM, Catron KM, van Wijnen AJ, McCabe LR, Lian JB, Stein GS, Stein JL 1994 Transcriptional control of the tissue-specific, developmentally regulated osteocalcin gene requires a binding motif for the Msx family of homeodomain proteins. Proc Natl Acad Sci USA 91:12887-12891
35. Vocke C, Bastia D 1983 DNA-protein interaction at the origin of DNA replication of the plasmid pSC101. Cell 35:495-502
36. Sarapura VD, Wood WM, Gordon DF, Ridgway EC 1992 A cell line which produces the glycoprotein hormone α-subunit contains specific nuclear factors similar to those present in thyrotropes. Thyroid 2:31-38
37. Catron KM, Her N, Abate C 1993 Nucleotides flanking a conserved TAAT core dictate the DNA binding specificity of three murine homeodomain proteins. Mol Cell Biol 13:2354-2365
38. Catron KM, Zhang H, Marshall SC, Inostroza JA, Wilson JM, Abate C 1995 Transcriptional repression by Msx-1 does not require homeodomain DNA-binding sites. Mol Cell Biol 15:861-871
39. Zhang H, Catron KM, Abate-Shen C 1996 A role for the Msx-1 homeodomain in transcriptional regulation: residues in the N-terminal arm mediate TATA binding protein interaction and trancriptional repression. Proc Natl Acad Sci USA 93:1764-1769
40. Hewitt JE, Clarke LN, Ivens A, Williamson R 1991 Structure and sequence of the human homeobox gene HOX7. Genomics 11:670-678
41. Simmons DM, Voss JW, Holloway JM, Broide RS, Rosenfeld MG, Swanson LW 1990 Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors. Genes Dev 4:695-711
42. Lyons GE, Houzelstein D, Sassoon D, Robert B, Buckingham ME 1992 Multiple sites of Hox-7 expression during mouse embryogenesis: comparison with retinoic acid receptor mRNA localization. Mol Reprod Dev 32:303-314
43. Reginelli AD, Wang Y-Q, Sassoon D, Muneoka K 1995 Digit tip regeneration correlates with regions of Msx1 (Hox 7) expression in fetal and newborn mice. Development 121:1065-1076
44. MacKenzie A, Ferguson MWJ, Sharpe PT 1992 Expression patterns of the homeobox gene, Hox-8, in the mouse embryo suggests a role in specifying tooth initiation and shape. Development 115:403-420
45. Nishikawa K, Nakanishi T, Aoki C, Hattori T, Takahashi K, Taniguchi K, Taniguchi S 1994 Differential expression of homeobox-containing genes Msx-1 and Msx-2 and homeoprotein Msx-2 expression during chick craniofacial development. Biochem Mol Biol Int 32:763-771
46. Hodgkinson JE, Davidson CL, Beresford J, Sharpe PT 1993 Expression of a human homeobox-containing gene is regulated by 1,25(OH)2D3 in bone cells. Biochim Biophys Acta 1174:11-16
47. Towler DA, Rutledge SJ, Rodan GA 1994 Msx2/Hox 8.1: a transcriptional regulator of the rat osteocalcin promoter. Mol Endocrinol 8:1484-1493
48. Shimeld SM, McKay IJ, Sharpe PT 1996 The murine homeobox gene Msx-3 shows highly restricted expression in the developing neural tube. Mech Dev 55:201-210
49. Catron KM, Wang H, Hu G, Shen MM, Abate-Shen C 1996 Comparison of MSX-1 and MSX-2 suggests a molecular basis for functional redundancy. Mech Dev 55:185-199
50. Wang Y, Sassoon D 1995 Ectoderm-mesenchyme and mesenchyme interactions regulate Msx-1 expression and cellular differentiation in the murine limb bud. Dev Biol 168:374-382
51. Simon H-G, Nelson C, Goff D, Laufer E, Morgan BA, Tabin C 1995 Differential expression of myogenic regulatory genes and Msx-1 during dedifferentiation and redifferentiation of regenerating amphibian limbs. Dev Dynam 202:1-12
52. Mina M, Gluhak J, Upholt WB, Kollar EJ, Rogers B 1995 Experimental analysis of Msx-1 and Msx-2 gene expression during chick mandibular morphogenesis. Dev Dynam 202:195-214
53. Ferrari D, Kosher RA, Dealy CN 1994 Limb mesenchymal cells inhibited from undergoing cartilage differentiation by a tumor promoting phorbol ester maintain expression of the homeobox-containing gene Msx1 and fail to exhibit gap junctional communication. Biochem Biophys Res Commun 205:429-434
54. Song K, Wang Y, Sassoon D 1992 Expression of Hox-7.1 in myoblasts inhibits terminal differentiation and induces cell transformation. Nature 360:477-481
55. Isaac VE, Sciavolino P, Abate C 1995 Multiple amino acids determine the DNA binding specificity of the Msx1 homeodomain. Biochemistry 34:7127-7134
56. Woloshin P, Song K, Degnin C, Killary AM, Goldhamer D 1995 MSX1 inhibits MyoD expression in fibroblast × 10T1/2 cell hybrids. Cell 82:611-620
57. Goldhamer DJ, Brunk BP, Faerman A, King A, Shani M, Emerson CPJ 1995 Embryonic activation of the myoD gene is regulated by a highly conserved distal control element. Development 121:637-649
58. Dodig M, Kronenberg MS, Bedalov A, Kream BE, Gronowicz G, Clark SH, Mack K, Liu Y-H, Maxon R, Pan Z-Z, Upholt WB, Rowe DW, Lichtler AC 1996 Identification of a TAAT-containing motif required for high level expression of the COL1A1 promoter in differentiated osteoblasts of transgenic mice. J Biol Chem 271:16422-16429
59. Golos TG, Durning M, Fisher JM 1991 Molecular cloning of the rhesus monkey glycoprotein hormone α-subunit gene. DNA Cell Biol 10:367-380
60. Kato Y, Erashi T, Hirai T, Kato T 1991 The gene for the common α subunit of porcine pituitary glycoprotein hormone. J Mol Endocrinol 7:27-34
61. Palazzolo MJ, Hamilton BA, Ding D, Martin CH, Mead DA, Mierendorf RC, Raghavan KV, Meyerowitz EM, Lipshitz HD 1990 Phage λ cDNA cloning vectors for subtractive hybridization, fusion-protein synthesis and CreloxP automatic plasmid subcloning. Gene 88:25-36
62. Gubler U, Hoffman BJ 1983 A simple and very efficient method for generating cDNA libraries. Gene 25:263-269
63. Meissner PS, Sisk WP, Berman ML 1987 Bacteriophage λ cloning system for the construction of directional cDNA libraries. Proc Natl Acad Sci USA 84:4171-4175
64. Gordon DF, Wagner J, Atkinson BL, Chiono M, Berry R, Sikela J, Gutierrez-Hartmann A 1996 Human Cart-1: structural organization, chromosomal localization, and functional analysis of a cartilage-specific homeodomain cDNA. DNA Cell Biol 15:531-541
65. Gordon DF, Wood WM, Ridgway EC 1988 Organization and nucleotide sequence of the mouse α-subunit gene of the pituitary glycoprotein hormones. DNA 7:679-690
66. Benton WD, Davis RW 1977 Screening λ gt recombinant clones by hybridization to single plaques in situ. Science 196:180-182
67. Sanger F, Nicklen S, Coulson AR 1977 DNA sequencing with chain terminating inhibitors. Proc Natl Acad Sci USA 74:5463-5468
68. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ 1990 Basic local alignment search tool. J Mol Biol 215:403-410
69. Gordon DF, Haugen BR, Sarapura VDS, Nelson AR, Wood WM, Ridgway EC 1993 Analysis of Pit-1 in regulating mouse TSHβ promoter activity in thyrotropes. Mol Cell Endocrinol 96:75-84
70. Church GM, Gilbert W 1984 Genomic sequencing. Proc Natl Acad Sci USA 81:1991-1995
71. Rigby PWJ, Dieckmann M, Rhodes C, Berg P 1977 Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase. J Mol Biol 113:237-251
72. Kozak M 1987 An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res 15:8125-8145
73. Bradford MM 1976 A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 72:248-254
74. Ocran KW, Sarapura VD, Wood WM, Gordon DF, Gutierrez-Hartmann A, Ridgway EC 1990 Identification of cis-acting promoter elements important for expression of the mouse glycoprotein hormone α-subunit gene in thyrotropes. Mol Endocrinol 4:766-772