Increase in plasma levels of clozapine and norclozapine after administration of nefazodone [4]

Journal of Clinical Psychiatry

Volumn 62, Issue 5, 2001, Pages 375-376

  Khan, A Y ^a   Preskorn, S H ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE WICHITA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; CYTOCHROME P450 3A4; NEFAZODONE; NORCLOZAPINE; RISPERIDONE;

ADULT; ANXIETY; CASE REPORT; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG METABOLISM; DRUG POTENTIATION; HUMAN; HYPOTENSION; LETTER; MALE; NEGATIVE SYNDROME; PRIORITY JOURNAL; SCHIZOPHRENIA; VERTIGO;

EID: 0034971228     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: 10.4088/JCP.v62n0512d     Document Type: Letter

References (8)

1. The assay of clozapine and N-desmethylclozapine in human serum by high-performance liquid chromatography
2. Nefazodone, metachlorophenylpiperazine, and their metabolites in vitro: Cytochromes mediating transformation, and P450-3A4 inhibitory actions
3. The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine
4. Coadministration of nefazodone and benzodiazepines: A pharmacokinetic interaction study with triazolam
5. Serum concentration of clozapine and norclozapine are unaffected by the potent CYP3A4 inhibitor itraconazole
6. The effect of nefazodone on clozapine plasma concentrations
7. Seizure following addition of erythromycin to clozapine treatment
8. Erythromycin induced clozapine toxic reaction