Cytotoxicity of the MEIC reference chemicals in antioxidant-enriched rat hepatoma-derived Fa32 cells

Alternatives to Laboratory Animals

Volumn 29, Issue 3, 2001, Pages 217-223

  Dierickx, P J ^a   Smit, C ^a   Scheers, E M ^a  

^a Laboratorium Biochemische Toxikologie   (Belgium)

Author keywords

Antioxidant status; Cytotoxicity; Fa32 cells; Human toxicity; Neutral red uptake; Protection; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; CAFFEINE; GLUTATHIONE; NEUTRAL RED; PARACETAMOL; REACTIVE OXYGEN METABOLITE; SODIUM CHLORIDE;

ANIMAL CELL; CELL PROTECTION; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; HEPATOMA CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REFERENCE VALUE; TOXICITY TESTING;

EID: 0034968524     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290102900304     Document Type: Conference Paper

References (14)

1. MEIC evaluation of acute systemic toxicity. Part I. Methodology of 68 in vitro toxicity assays used to test the first 30 reference chemicals
2. MEIC evaluation of acute systemic toxicity. Part II. In vitro results from 68 toxicity assays used to test the first 30 reference chemicals and a comparative cytotoxicity analysis
3. MEIC evaluation of acute systemic toxicity. Part IV. In vitro results from 67 toxicity assays used to test reference chemicals 31-50 and a comparative cytotoxicity analysis
4. MEIC evaluation of acute systemic toxicity. Part V. Rodent and human toxicity data for the 50 reference chemicals
5. MEIC evaluation of acute systemic toxicity. Part VI. The prediction of human toxicity by rodent LD50 values and results from 61 in vitro methods
6. Protein measurement with the Folin phenol reagent
7. Overview of the final MEIC results. II. The in vitro-in vivo evaluation, including the selection of a practical battery of cell tests for prediction of acute lethal blood concentration in humans
8. Cytotoxicity of the MEIC reference chemicals in rat hepatoma-derived Fa32 cells
9. Stimulation of NADPH-dependent reactive oxygen species formation and DNA damage by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat peritoneal lavage cells
10. Glutathione disulfide enhances the reduced glutathione inhibition of lipid peroxidation in rat liver microsomes
11. Cadmium toxicity: Unique cytoprotective properties of alpha-tocopheryl succinate in hepatocytes
12. Correlation between the in vitro cytotoxicity to cultured fathead minnow fish cells and fish lethality data for 50 chemicals
13. Toxicity monitored with a correlated set of cell culture assays
14. Increased cytotoxic sensitivity of cultured FHM fish cells by simultaneous treatment with sodium dodecyl sulphate and buthionine sulfoximine