IL-18, a product of choriodecidual cells, increases during premature rupture of membranes but fails to turn on the Fas - FasL-mediated apoptosis pathway

Journal of Assisted Reproduction and Genetics

Volumn 18, Issue 5, 2001, Pages 276-284

  Menon, Ramkumar ^a   Lombardi, Salvatore J ^a   Fortunato, Stephen J ^a  

^a Perinatal Research Center   (United States)

Author keywords

Amniotic fluid; Apoptosis; Fas FasL; Fetal membranes; IL 18; PROM

Indexed keywords

CASPASE 8; FAS ANTIGEN; FAS LIGAND; INTERLEUKIN 18; MESSENGER RNA;

AMNION FLUID; APOPTOSIS; ARTICLE; CHORION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DECIDUA; ENZYME LINKED IMMUNOSORBENT ASSAY; FETUS; GENE EXPRESSION; GENE LOCATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; PREGNANCY COMPLICATION; PREMATURE FETUS MEMBRANE RUPTURE; PREMATURE LABOR; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMNIOTIC FLUID; ANTIGENS, CD95; APOPTOSIS; CHORION; DECIDUA; ENZYME-LINKED IMMUNOSORBENT ASSAY; FAS LIGAND PROTEIN; FEMALE; FETAL MEMBRANES, PREMATURE RUPTURE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTERLEUKIN-18; MEMBRANE GLYCOPROTEINS; MODELS, BIOLOGICAL; ORGAN CULTURE TECHNIQUES; POLYMERASE CHAIN REACTION; PREGNANCY; PROTEIN STRUCTURE, TERTIARY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 0034964338     PISSN: 10580468     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016626620137     Document Type: Article

References (19)

1. Cloning of a new cytokine that induces IFN-gamma production by T cells
2. Overview of IL-18: More than an interferon-gamma inducing factor
3. Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme
4. Purification and characterization of the human IL-18 receptor
5. IL-18 activates NF-kappaB in murine T helper type 1 cells
6. Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-FasL- and perforin-induced tumor apoptosis, respectively
7. Interleukin 18 enhances FasL expression and induces apoptosis in Fas-expressing human myelomonocytic KG-1 cells
8. Cytokine networking in the placenta
9. Premature labor and intra-amniotic infection. Clinical aspects and role of the cytokines in diagnosis and pathophysiology
10. Programmed cell death (apoptosis): A possible pathway to metalloproteinase activation and fetal membrane degradation in pPROM
11. Expression of inflammatory cytokines (IL-1, IL-6) in amniochorion
12. Gene expression, synthesis, and secretion of interleukin 18 and interleukin1beta are differentially regulated in human blood mononuclear cells and mouse spleen cells
13. MMP/TIMP imbalance in amniotic fluid during PPPROM: An indirect support for endogenous pathway to membrane rupture
14. Amniochorion gelatinase-gelatinase inhibitor imbalance in vitro: A possible infectious pathway to rupture
15. IL-18: A novel cytokine tat augments both innate and acquired immunity
16. IL-15, a novel cytokine produced by human fetal membranes increases during preterm labor
17. Apoptosis and Fas expression in human fetal membranes
18. A role of the cell death factor system (Fas/FasL) in spontaneous rupture of membranes
19. Death receptor Fas/Apo-1/CD95 expressed by human placental cytotrophoblasts does not mediate apoptosis