Benzodiazepine-induced chemotaxis is impaired in monocytes from patients with generalized anxiety disorder

Psychoneuroendocrinology

Volumn 24, Issue 2, 1999, Pages 243-249

  Sacerdote, P ^a   Panerai, A E ^a   Frattola, L ^b   Ferrarese, C ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b SAN GERARDO HOSPITAL   (Italy)

Author keywords

Anxiety disorder; Chemotaxis; Monocytes; Peripheral benzodiazepine receptor

Indexed keywords

4' CHLORODIAZEPAM; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR; CHEMOATTRACTANT; DIAZEPAM; FORMYLMETHIONYLLEUCYLPHENYLALANINE;

ADULT; AGED; ANXIETY NEUROSIS; ARTICLE; CHEMOTAXIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; MALE; MONOCYTE; MONONUCLEAR CELL; PRIORITY JOURNAL;

ADULT; AGED; ANTI-ANXIETY AGENTS; ANXIETY DISORDERS; BENZODIAZEPINES; BENZODIAZEPINONES; CHEMOTAXIS, LEUKOCYTE; DIAZEPAM; FEMALE; HUMANS; MALE; MIDDLE AGED; MONOCYTES; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE;

EID: 0033019292     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4530(98)00079-1     Document Type: Article

References (29)

1. Hill K. Diagnostic and Statistical Manual of Mental Disorders. 4th:1994;American Psychiatric Association, Washington, DC.
2. Anholt P.R.H., Pedersen P.L., DeSouza E.B., Snyder S.H. The peripheral type benzodiazepine receptor. Localization to the mitochondria outer membrane. J. Biol. Chem. 261:1986;576-583.
3. Berkovich A., Ferrarese C., Cavaletti G., Alho H., Marzorati C., Bianchi G., Guidotti A., Costa E. Topology of two DBI receptors in human lymphocytes. Life Sci. 52:1993;1265-1277.
4. Blalock J.A. Molecular basis for bidirectional communication between the immune and neuroendocrine system. Physiol. Rev. 69:1990;1-31.
5. Bond P.A., Cundall R., Rolfe B. 3H-diazepam binding to human granulocytes. Life Sci. 37:1985;11-16.
6. Drugan R.C., Basile A.S., Crawley J.N., Paul S.M., Skolnick P. Inescapable shock reduces H3 RO-5-4864 binding to peripheral type benzodiazepine receptors in the rat. Pharmacol. Biochem. Behav. 24:1986;1673-1677.
7. Ferrarese C., Apollonio I., Bianchi G., Frigo M., Marzorati C., Pecora N., Perego M., Pierpaoli C., Frattola L. Benzodiazepine receptors and diazepam binding inhibitor: a possible link between stress, anxiety and the immune system. Psychoneuroendocrinology. 18:1993;1-22.
8. Ferrarese C., Apollonio I., Frigo M., Perego M., Pierpaoli C., Trabucchi M., Frattola L. Characterization of peripheral benzodiazepine receptors in human blood mononuclear cells. Neuropharmacology. 29:1990;375-378.
9. Ferrarese C., Apollonio I., Frigo M., Perego M., Piolti R., Trabucchi M. Decreased density of benzodiazepine receptors in lymphocytes of anxious patients: reversal after chronic diazepam treatment. Acta Psychiatr. Scand. 84:1990;537-544.
10. Ferrarese C., Mennini T., Pecora N., Pierpaoli C., Frigo M., Marzorati C., Gobbi M., Bizzi A., Codegoni A., Garattini S., Frattola L. Diazepam binding inhibitor increase after acute stress in the rat. Neuropharmacology. 30:1991;1445-1452.
11. Gavish M., Laor N., Bidder M., Fisher D., Fonia O., Muller U., Reiss A., Wolmer L., Karp L., Weizman R. Altered platelet peripheral-type benzodiazepine receptor in postratumatic stress disorder. Neuropsychopharmacology. 14:1996;181-186.
12. Hamilton M. The assessment of anxiety states by rating. Br. J. Med. Psychol. 32:1959;50-55.
13. Johnson M.R., Marazziti D., Brawman-Mintzer O., Emmanuel N.P., Ware M.R., Morton W.A., Rossi A., Cassano G.B., Lydiard R.B. Abnormal peripheral benzodiazepine receptor density associated with generalized social phobia. Biol. Psychiatry. 43:1998;306-309.
14. Law P.Y., Hom D.S., Loh H.H. Opiate receptor downregulaton and desensitization in neuroblastoma×glioma NG 108-15 cells are two separate cellular adaptation processes. Mol. Pharmacol. 23:1983;25-35.
15. Marazziti D., Rotondo A., Martini C., Giannaccini G., Lucacchini A., Pancioli-Guadagnucci M.L., Diamond B.I., Borison R., Cassano G.B. Changes in peripheral benzodiazepine receptors in patients with panic disorders and obsessive compulsive disorder. Neuropsychobiology. 29:1994;8-11.
16. Mennini T., Gobbi M., Caruchinda C. Noise induced opposite changes in central and peripheral benzodiazepine receptors in rat brain cortex. Neurosci. Res. Commun. 5:1989;27-34.
17. Novas M.L., Medina J.H., Calvo D., De Robertis E. Increase of peripheral type benzodiazepine binding sites in kidney and olfactory bulbs in acutely stressed rats. Eur. J. Pharmacol. 135:1987;243-246.
18. Ottaway C.A. In vitro alteration of receptor for vasoactive intestinal peptide changes the in vivo localization of mouse T-cells. J. Exp. Med. 160:1984;820s-826.
19. Rocca P., Bellone G., Benna P., Bergamasco B., Ravizza L., Ferrero P. Peripheral type benzodiazepine receptors and diazepam binding inhibitor like immunoreactivity distribution in human peripheral mononuclear cells. Immunopharmacology. 25:1993;163-178.
20. Ruff M.R., Pert C.B., Weber R.J., Wahl L.M., Wahl S., Paul S.M. Benzodiazepine receptor-mediated chemotaxis of human monocytes. Science. 229:1985;1281-1283.
21. Sacerdote P., Bianchi M., Panerai A.E. Human monocyte chemotaxis activity of calcitonin somatostatin related peptides: modulation by chronic peptide treatment. J. Clin. Endocrinol. Metab. 70:1990;141-148.
22. Sacerdote P., Locatelli L.D., Panerai A.E. Benzodiazepine induced chemotaxis of human monocytes: a tool for the study of benzodiazepine receptors. Life Sci. 53:1993;653-658.
23. Spitzer R.L., Williams J.B. Revised diagnostic criteria and a new structural interview for diagnosing anxiety disorders. J. Psych. Res. 22s:1988;55-85.
24. Taupin V., Herbelin A., Deschamps Latcha B., Zavala F. Endogenous anxiogenic peptide, ODN-diazepam-binding inhibitor, and benzodazepines enhance the production of IL-1 and tumor necrosis factor by human monocytes. Lymphokine Res. 10:1991;7-13.
25. Weizman A., Burgin R., Harel Y., Gavish M. Platelet peripheral type benzodiazepine receptor in major depression. J. Affect. Disord. 33:1995;257-261.
26. Weizman R., Tanne Z., Karp L., Tyano S., Gavish M. Peripheral type benzodiazepine-binding sites in plateletes os schizophrenics with and without tardive dyskinesia. Life Sci. 39:1986;549-555.
27. Zavala F., Haumont J., Lenfant M. Interaction of benzodiazepines with mouse macrophages. Eur. J. Pharmacol. 106:1985;561-566.
28. Zavala F., Lenfant M. Peripheral benzodiazepines enhance the respiratory burst of machrophage -like P388D1 cells stimulated by arachidonic acid. Int. J. Immunopharmacol. 9:1987;269-274.
29. Zavala F. Benzodiazepine, anxiety and immunity. Pharmacol. Ther. 75:1997;199-216.