Effects of mechanical ventilation of isolated mouse lungs on surfactant and inflammatory cytokines

European Respiratory Journal

Volumn 17, Issue 3, 2001, Pages 488-494

  Veldhuizen, R A W ^a   Slutsky, A S ^a   Joseph, M ^a   McCaig, L ^a  

^a LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

Author keywords

ARDS; Lung injury; Mechanical ventilation; Surfactant

Indexed keywords

CYTOKINE; INTERLEUKIN 6; LUNG SURFACTANT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; CHEMICAL COMPOSITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE RELEASE; GENETIC ENGINEERING; INFLAMMATION; ISOLATED ORGAN; LUNG; LUNG COMPLIANCE; LUNG INJURY; LUNG INSUFFICIENCY; LUNG LAVAGE; MALE; MORPHOLOGY; MOUSE; NONHUMAN; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; RANDOMIZATION; RESPIRATORY DISTRESS; SYNDROME; TIDAL VOLUME;

ANIMALS; INFLAMMATION; INTERLEUKIN-6; LUNG; MALE; MICE; MICE, INBRED BALB C; POSITIVE-PRESSURE RESPIRATION; PULMONARY SURFACTANTS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034959051     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.01.17304880     Document Type: Article

References (39)

1. Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome
2. Low mortality rate in adult respiratory distress syndrome using low-volume, pressure-limited ventilation with permissive hypercapnia: A prospective study
3. NHLBI clinical trial stopped early: Successful ventilation strategy found for intensive care patients on life support
4. Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome. The Multicenter Trail Group on tidal volume reduction in ARDS
5. Evaluation of a ventilation strategy to prevent barotrauma in patients at high risk for acute respiratory distress syndrome. Pressure- and Volume-Limited Ventilation Strategy Group
6. Ventilator-induced lung injury: Lessons from experimental studies
7. Mechanisms of ventilation-induced lung injury: Physiological rationale to prevent it
8. Role of tidal volume, FRC, and end-expiratory volume in the development of pulmonary edema following mechanical ventilation
9. Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model
10. Tidal ventilation at low airway pressures can augment lung injury
11. Ventilation strategies affect surfactant aggregate conversion in acute lung injury
12. Alveolar surfactant aggregate conversion in ventilated normal and injured rabbits
13. Surfactant impairment after mechanical ventilation with large alveolar surface area changes and effects of positive end-expiratory pressure
14. Pulmonary surfactant is altered during mechanical ventilation of isolated rat lung
15. Altered surfactant function and metabolism in rabbits with acute lung injury
16. A rapid method of total lipid extraction and purification
17. A rapid sensitive method for determining phospholipid phosphorus involving digestion with magnesium nitrate
18. Deficient hydrophilic lung surfactant proteins A and D with normal surfactant phospholipid molecular species in cystic fibrosis
19. The American-European consensus conference on ARDS: Definitions, mechanisms, relevant outcomes, and clinical trial coordination
20. Multi system organ failure: Is mechanical ventilation a contributing factor?
21. Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: A randomized controlled trial
22. Effects of lung injury on pulmonary surfactant aggregate conversion in vivo and in vitro
23. Lung overinflation without positive end-expiratory pressure promotes bacteremia after experimental Klebsiella pneumoniae inoculation
24. Pulmonary surfactant subfractions in patients with the acute respiratory distress syndrome
25. Surfactant alterations in severe pneumonia, acute respiratory distress syndrome, and cardiogenic lung edema
26. Phospholipid lung profile in adult respiratory distress syndrome - Evidence for surfactant abnormality
27. Alterations of the endogenous surfactant system in septic adult rats
28. Altered alveolar surfactant is an early marker of acute lung injury in septic adult sheep
29. Changes in subphase aggregates in rabbits injured by free fatty acid
30. Effects of surfactant subfractions on preterm rabbit lung function
31. The release of surfactant in rat lung by brief periods of hyperventilation
32. Regulatory mechanisms of surfactant secretion
33. Inhibition of surfactant subtype convertase in radiation model of adult respiratory distress syndrome
34. Surfactant subtypes in experimental lung damage: Radiation pneumonitis
35. Pulmonary surfactant subtype metabolism is altered after short-term ozone exposure
36. Experimental radiation pneumonitis. Corticosteroids increase the replicative activity of alveolar type 2 cells
37. The function of surfactant is impaired during the reimplantation response in rat lung transplants
38. Bovine pulmonary surfactant: Chemical composition and physical properties
39. Inflammatory chemical mediators during conventional ventilation and during high frequency oscillatory ventilation