Prophylactic intravenous ondansetron reduces the incidence of intrathecal morphine-induced pruritus in patients undergoing cesarean delivery

Anesthesia and Analgesia

Volumn 91, Issue 1, 2000, Pages 172-175

  Yeh, Heui Ming ^a   Chen, Li Kuei ^a   Lin, Chen Jung ^a   Chan, Wei Hung ^a   Chen, Yen Po ^a   Lin, Chou Shun ^a   Sun, Wei Zen ^a   Wang, Ming Jiuh ^a   Tsai, Shen Kou ^a  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; DIPHENHYDRAMINE; MORPHINE; ONDANSETRON;

ADULT; ARTICLE; CESAREAN SECTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; FLATULENCE; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROPHYLAXIS; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SPINAL ANESTHESIA; TREATMENT OUTCOME;

EID: 0033943525     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/00000539-200007000-00032     Document Type: Article

References (23)

1. Cousins MJ, Mather LE. Intrathecal and epidural administration of opioids. Anesthesiology 1984;61:276-310.
2. Chaney MA. Side effects of intrathecal and epidural opioids. Can J Anaesth 1995;42:891-903.
3. Ballantyne JC, Loach AB, Carr DB. Itching after epidural and spinal opiates. Pain 1988;33:149-60.
4. Wilde M, Markham A. Ondansetron: a review of its pharmacology and preliminary clinical findings in novel applications. Drugs 1996;52:773-94.
5. Schwörer H, Ramadori G. Treatment of pruritus: a new indication for serotonin type 3 receptor antagonists. Clin Invest 1993; 71:659-62.
6. Schwörer H, Ramadori G. Improvement of cholestatic pruritus by ondansetron [letter]. Lancet 1993;341:1277.
7. Raderer M, Muller C, Scheithauer W. Ondansetron for pruritus due to cholestasis [letter]. N Engl J Med 1994;30:1540.
8. Balaskas EV, Bamihas GI, Karamouzis M, et al. Histamine and serotonin in uremic pruritus: effect of ondansetron in CAPD-pruritic patients. Nephron 1998;78:395-402.
9. Larijani GE, Goldberg ME, Rogers KH. Treatment of opioid-induced pruritus with ondansetron: report of four patients. Pharmacotherapy 1996;16:958-60.
10. Arai L, Stayer S, Schwartz R, Dorsey A. The use of ondansetron to treat pruritus associated with intrathecal morphine in two paediatric patients. Paediatr Anaesth 1996;6:337-9.
11. Crighton IM, Hobbs GJ, Reid MF. Ondansetron for the treatment of pruritus after spinal opioids. Anaesthesia 1996;51: 199-200.
12. Borgeat A, Stirnemann HR. Ondansetron is effective to treat spinal or epidural morphine-induced pruritus. Anesthesiology 1999;90:432-6.
13. Milner AR, Bogod DG. Intrathecal administration of morphine for elective cesarean section. Anaesthesia 1996;51:871-3.
14. Swart M, Sewell J, Thomas D. Intrathecal morphine for caesarean section: an assessment of pain relief, satisfaction, and side effects. Anaesthesia 1997;52:373-7.
15. Baguley WA, Hay WT, Mackie KP, et al. Cardiac dysrhythmias associated with the intravenous administration of ondansetron and metoclopramide. Anesth Analg 1997;84:1380-1.
16. Hamon M, Gallissot MC, Menard F, et al. 5-HT3 receptor binding sites are on capsaicin-sensitive fibres in the rat spinal cord. Eur J Pharmacol 1989;164:315-22.
17. Waeber C, Dixon K, Hoyer D, Palacios JM. Localisation by autoradiography of neuronal 5-HT3 receptors in the mouse CNS. Eur J Pharmacol 1988;151:351-2.
18. Laporte AM, Doyen C, Nevo IT, et al. Autoradiographic mapping of serotonin 5-HT1A, 5-HT1D, 5-HT2A and 5-HT3 receptors in the aged human spinal cord. J Chem Neuroanat 1996;11: 67-75.
19. Thomas DA, Williams GM, Iwata K, et al. The medullary dorsal horn: a site of action of morphine in producing facial scratching in monkeys. Anesthesiology 1993;79:548-54.
20. Richardson BP. Serotonin and nociception. Ann NY Acad Sci 1990;600:511-20.
21. Fan P. Nonopioid mechanism of morphine modulation of the activation of 5-hydroxytryptamine type 3 receptors. Mol Pharmacol 1995;47:491-5.
22. Saiah M, Borgeat A, Wilder-Smith OHG, et al. Epidural-morphine-induced pruritus: propofol vs naloxone. Anesth Analg 1994;78:1110-3.
23. Simpson KH, Hicks FM. Clinical pharmacokinetics of ondansetron: a review. J Pharm Pharmacol 1996;48:774-81.