Practicalities and ethics of running clinical trials in paediatric oncology - The UK experience

European Journal of Cancer

Volumn 37, Issue 11, 2001, Pages 1394-1398

  Estlin, E J ^a   Ablett, S ^b  

^a ROYAL MANCHESTER CHILDREN S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BOLDENONE UNDECENOATE; CARBOPLATIN; ETOPOSIDE; IFOSFAMIDE;

ANTINEOPLASTIC ACTIVITY; CANCER SURVIVAL; CHILDHOOD CANCER; CLINICAL STUDY; CLINICAL TRIAL; CONFERENCE PAPER; DRUG EFFICACY; DRUG SCREENING; DRUG TOLERABILITY; ETHICS; FINANCIAL MANAGEMENT; HUMAN; INFORMED CONSENT; LAW; LEUKEMIA; MEDICAL AUDIT; MOTIVATION; PEDIATRICIAN; PRACTICE GUIDELINE; PRIORITY JOURNAL; SOLID TUMOR; UNITED KINGDOM; UNITED STATES;

EID: 0034950276     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(01)00124-1     Document Type: Conference Paper

References (23)

1. The U.S Pediatric cancer clinical trials programmes: International implications and the way forward
2. European community commission notes for guidance: Good clinical practice for trials of medicinal products in the European community
3. EU GCP Directive: Proposal for a European Parliament and Council Directive on the Approximation of the laws, regulations and administrative provisions of the member states relating to the implementation of good clinical practice in the conduct of clinical trials on medicinal products for human use (COM (97) 0369-c4-0446/97.97/0197(COD)
4. Ethical issues in the development of new agents
5. Impact of therapeutic research on informed consent and the ethics of clinical trials: A medical oncology perspective
6. Cancer registries fear imminent collapse
7. Tolerance to antineoplastic agents in children and adults
8. Conduct of phase I trials in children with cancer
9. Phase I trials in pediatric oncology: Perceptions of pediatricians from the United Kingdom children's cancer study group and the pediatric oncology group
10. Phase I study of Thymitaq (AG337) in pediatric patients with advanced malignancy
11. Grading of toxicity
12. Phase I therapy trials in children with cancer
13. Perceptions of cancer patients and their physicians in phase I trials
14. Patients in phase trials of anti-cancer agents in Japan: Motivation, comprehension and expectations
15. Study of cohort-specific consent and patient control in phase I cancer trials
16. Phase I study of escalating targeted doses of carboplatin combined with ifosfamide and etoposide in treatment of newly diagnosed pediatric solid tumours
17. Continual reassessment methods in phase I trials of the combination of two drugs in oncology
18. Phase I clinical trials: Adapting methodology to face new challenges
19. Pediatric phase II cancer chemotherapy trials, a pediatric oncology group study
20. One-sided multiple testing procedure for phase II clinical trials
21. Cancer clinical trials: Design, conduct, analysis and reporting
22. Central pathology review in clinical trials for patients with malignant glioma. A report of radiation therapy oncology group 83-02
23. Informed versus randomised consent to clinical trials