Therapeutic ultrasound for gene delivery

Echocardiography

Volumn 18, Issue 4, 2001, Pages 349-353

  Porter, Thomas R ^a,b   Xie, Feng ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA AT OMAHA   (United States)

Author keywords

Gene therapy; Microbubbles; Oligonucleotides; PESDA; Ultrasound

Indexed keywords

ALBUMIN; ANTISENSE OLIGONUCLEOTIDE; FLUOROCARBON; GLUCOSE; MICROSPHERE; MYC PROTEIN; OLIGONUCLEOTIDE; PERFLUOROCARBON EXPOSED SONICATED DEXTROSE ALBUMIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTERY INTIMA PROLIFERATION; ARTICLE; CAROTID ARTERY; CORONARY ARTERY; DRUG RELEASE; GENE TARGETING; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; ULTRASOUND;

EID: 0034949891     PISSN: 07422822     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1540-8175.2001.00349.x     Document Type: Article

References (14)

1. Interaction of diagnostic ultrasound with synthetic oligonucleotide-labeled perfluorocarbon-exposed sonicated dextrose albumin microbubbles
2. Ultrasound enhances PESDA-linked oligonucleotide deposition into myocardial tissue
3. Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue
4. Delivery of colloidal particles and red blood cells to tissue through microvessel ruptures created by targeted microbubble destruction with ultrasound
5. Acoustically active lipospheres containing paclitaxel, a new therapeutic ultrasound contrast agent
6. Inhibition of carotid artery neointimal formation with intravenous microbubbles
7. Enhanced delivery and effectiveness of antisense oligonucleotides when bound to intravenous perfluorocarbon-filled microbubbles: Effect of ultrasound and therapeutic implications
8. Transcatheter delivery of c-myc antisense oligomers reduces neointimal formation in a porcine model of coronary artery balloon injury
9. Inhibition of carotid artery neointimal formation following balloon injury using ultrasound-targeted deposition of antisense to C-MYC protooncogene bound to intravenously delivered perfluorocarbon microbubbles
10. Detrimental effects of low frequency 20 kilohertz transthoracic ultrasound on coronary artery neointimal hyperplasia following balloon injury: Thirty day angiographic, histologic, and ultrasound intravascular observations
11. Echocardiographic destruction of albumin microbubbles directs gene delivery to the myocardium
12. In vivo transfection and gene expression in canine myocardium after intravenous injection of microbubble linked plasmid DNA and exposure to ultrasound
13. Tenfold augmentation of myocardial uptake of vascular endothelial growth factor with ultrasound after systematic administration
14. Ultrasound enhances reporter gene expression after transfection of vascular cells in vitro