Altered DNA-cleavage activity of topoisomerase II from WEHI-3B leukemia cells with specific resistance to ciprofloxacin

Anti-Cancer Drugs

Volumn 12, Issue 5, 2001, Pages 441-451

  Pessina, Augusto ^a   Raimondi, Alessandro ^a   Croera, Cristina ^a   Acchini, Mara ^a   Mineo, Elisabetta ^a   Foti, Paola ^a   Neri, Maria Grazia ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Ciprofloxacin; Drug resistance; Topoisomerases; WEHI 3B cells

Indexed keywords

CAMPTOTHECIN; CIPROFLOXACIN; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; ETOPOSIDE; LOMEFLOXACIN; OFLOXACIN; PEFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RUFLOXACIN; TENIPOSIDE; VERAPAMIL;

ANIMAL CELL; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DNA BINDING; DNA CLEAVAGE; DRUG ACCUMULATION; DRUG RESISTANCE; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME DEGRADATION; IMMUNOCYTOCHEMISTRY; LEUKEMIA CELL; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CAMPTOTHECIN; CELL DIVISION; CIPROFLOXACIN; DNA TOPOISOMERASES, TYPE II; DNA, NEOPLASM; DRUG RESISTANCE, NEOPLASM; LEUKEMIA, MYELOMONOCYTIC, ACUTE; TUMOR CELLS, CULTURED;

EID: 0034946259     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200106000-00005     Document Type: Article

References (32)

1. Multidrug resistance in the laboratory and clinic
2. Multidrug resistance in leukemia
3. Clinical multidrug resistance in cancer: A multifactorial problem
4. Topoisomerase I inhibitors and drug resistance
5. Cellular models for multiple drug resistance in cancer
6. Effect of 4 quinolones and novobiocin on calf thymus DNA polimerase α primase complex, topoisomerase I and II and growth of mammalian lymphoblast
7. Effects of fluoroquinolones on the in vitro proliferation of myeloid precursor cells
8. Significance of the methyl group on the oxazine ring of ofloxacin derivatives in the inhibition of bacterial and mammalian type II topoisomerases
9. +) leukemia cells
10. r 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance
11. A transplantable myelomonocytic leukemia in BALB/c mice: Cytology, caryotype and neuroaminidase content
12. Direct correlation between DNA topoisomerase II activity and cytotoxicity in adriamycin-sensitive and resistant P388 leukemia cell lines
13. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding
14. Rapid purification and characterization of DNA topoisomerase I from cultured mouse mammary carcinoma FM3A cells
15. Cleavage of structural proteins during the assembly of the head of the bacteriophage T4
16. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
17. In vitro and intracellular inhibition of topoisomerase II by the antitumor agent merbarone
18. Catalytic function of DNA-topoisomerase II
19. A fluorescence enhancement assay for cellular DNA damage
20. The role of strand separation in alkali of DNA of irradiated mammalian cells
21. A simple method of estimating fifty per cent endpoints
22. Inhibitory effects of quinolones on pro- and eucaryotic DNA topoisomerases I and II
23. Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme
24. Topoisomerase I and II activity in human breast, cervix, lung and colon cancer
25. Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitro camptothecin
26. Effects of Fleroxacin on HeLa cell functions and topoisomerase II
27. Development of a stable camptothecin-resistant subline of P388 leukemia with reduced topoisomerase I content
28. Camptothecin resistance involving steps subsequent to the formation of protein-linked DNA breaks in human camptothecin-resistant KB cell lines
29. Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: Correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential
30. Effects of quinolone derivates on eukaryotic topoisomerase II
31. Resistance of mammalian tumor cells to inhibitors of DNA topoisomerase II