Topographic analysis of K-ras mutations in histologically normal lung tissues and tumours of lung cancer patients

British Journal of Cancer

Volumn 85, Issue 2, 2001, Pages 235-241

  Keohavong, P ^a,b   Mady, H H ^a,c   Gao, W M ^a   Siegfried, J M ^a,b   Luketich, J D ^a,b   Melhem, M F ^a,c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Denaturing gradient gel electrophoresis; Laser capture microdissection; Lung carcinoma; ras oncogene

Indexed keywords

TUMOR MARKER;

ADULT; AGED; AMINO ACID SUBSTITUTION; ARTICLE; CLINICAL ARTICLE; CODON; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; LUNG ADENOCARCINOMA; LUNG CANCER; LUNG CARCINOGENESIS; LUNG SQUAMOUS CELL CARCINOMA; MALE; ONCOGENE K RAS; PRIORITY JOURNAL;

ADENOCARCINOMA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GENES, RAS; HUMANS; LUNG NEOPLASMS; MUTATION; POLYMERASE CHAIN REACTION;

EID: 0034941219     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.2001.1913     Document Type: Article

References (42)

1. ras genes
2. Identification of K-ras mutations in pancreatic juice in the early diagnosis of pancreatic cancer
3. Molecular themes in oncogenes
4. Microsatellite instability and K-ras mutations associated with pancreatic adenocarcinoma and pancreatitis
5. Analysis of K-ras gene mutations in malignant and nonmalignant endobronchial tissue obtained by fiberoptic bronchoscopy
6. H genes mutated at codon 61
7. Laser capture microdissection
8. The molecular basis of human lung cancer
9. Chemical and physical carcinogenesis: Advances and perspectives
10. p53 mutations in human cancers
11. K-ras mutations in human adenocarcinoma of the lung: Association with smoking and exposure to asbestos
12. Detection of K-ras mutations in lung carcinomas: Relationship to prognosis
13. Detection of low-fraction K-ras mutations in primary lung tumors using sensitive methods
14. Detection of infrequent and multiple K-ras mutations in human tumors and tumor-adjacent tissues
15. The ras signal transduction pathway
16. c-K-ras and p53 mutations occur very early in adenocarcinoma of the lung
17. Tumor suppressor genes
18. Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma
19. Mutant K-ras in apparently normal mucosa of colorectal cancer patients: Its potential as a biomarker of colorectal tumorigenesis
20. Lung cancen
21. Aberrant crypts: Putative preneoplastic foci in human colonic mucosa
22. Clinical significance of ras oncogene activation in human lung cancer
23. Molecular staging of non-small cell lung cancer according to K-ras genotypes
24. Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient
25. Biological properties of human c-H-ras genes mutated at codon 12
26. Field cancerization in oral stratified epithelium
27. Genetic evidence for an independent origin of multiple preneoplastic and neoplastic lung lesion
28. Molecular aspects of chemical carcinogenesis: The roles of oncogenes and tumor suppressor genes
29. Field cancerization in the aerodigestive tract - Its etiology, manifestation, and significance
30. ras gene mutation as a prognostic marker in adenocarcinoma of the human lung without lymph node metastasis
31. K-ras mutations are relatively late event in the pathogenesis of lung carcinomas
32. Detection of ras gene mutations in human lung cancer by single-stranded conformational polymorphism analysis of polymerase chain reaction products
33. Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease
34. Codon 12 Ki-ras mutation in non-small-cell lung cancer: Comparative evaluation in tumoural and non-tumoural lung
35. Detection of codon 12 K-ras mutations in non-neoplastic mucosa from bronchial carina in patients with lung cancer
36. K-ras oncogene activation in lung adenocarcinomas from former smokers
37. K-ras oncogene activation in atypical alveolar hyperplasia of the human lung
38. K-ras mutations in the duodenal fluid of patients with pancreatic carcinoma
39. High frequency of K-ras mutations in normal appearing lung tissues and sputum of patients with lung cancer
40. Frequent c-Ki-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation
41. K-ras mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients