Detection of low-fraction K-ras mutations in primary lung tumors using a sensitive method

International Journal of Cancer

Volumn 74, Issue 2, 1997, Pages 162-170

  Keohavong, Phouthone ^a,c   Zhu, Dan ^a   Melacrinos, Alea C ^a   DeMichele, Mary Ann A ^b   Weyant, Robert J ^a   Luketich, James D ^b,c   Testa, Joseph R ^d   Fedder, Madelyn ^d   Siegfried, Jill M ^b,c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^d FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; LUNG CARCINOMA; MAJOR CLINICAL STUDY; MALE; ONCOGENE K RAS; PRIORITY JOURNAL; PROGNOSIS;

ADENOCARCINOMA; AGED; CARCINOMA, ADENOSQUAMOUS; CARCINOMA, SQUAMOUS CELL; CODON; ELECTROPHORESIS; FEMALE; GENES, RAS; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; MUTATION; POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY;

EID: 0030910858     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970422)74:2<162::AID-IJC4>3.0.CO;2-X     Document Type: Article

References (28)

1. BARBACID, M., ras genes. Ann. Rev. Biochem., 56, 779-827 (1987).
2. BOS, J.L., ras oncogenes in human cancer: a review. Cancer Res., 49, 4682-4689 (1989).
3. CARIELLO, N.F., KEOHAVONG, P., KAT, A.G. and THILLY, W.G., Molecular analysis of complex human cell population: mutational spectra of MNNG and ICR-191. Mutation Res., 231, 165-176 (1990).
4. FISCHER, S.H. and LERMAN, L.S., DNA fragments differing by single base-pair substitutions separated in denaturing gradient gels: correspondence with melting theory. Proc. nat. Acad. Sci. (Wash.), 80, 1579-1583 (1983).
5. JIANG, W., KAHN, S.M., GUILLEM, J.G., LU, S. and WEINSTEIN, R.B., Rapid detection of ras oncogenes in human tumors: application to colon, esophageal, and gastric cancer. Oncogene, 4, 923-928 (1989).
6. KAPLAN, E.L. and MEIER, P., Nonparametric estimation for incomplete observations. J. Amer. Stat. Assoc., 53, 457-481 (1958).
7. KEOHAVONG, P., DE MICHELE, M.-A.A., MELACRINOS, A.C., LANDRENEAU, R.J., WEYANT, R.J. and SIEGFRIED, J.M., Detection of K-ras mutations in lung carcinomas: relationship to prognosis. Clin. Cancer Res., 2, 411-418 (1996).
8. KEOHAVONG, P. and THILLY, W.G., Fidelity of DNA polymerases in DNA amplification. Proc. nat. Acad. Sci. (Wash.), 86, 9253-9257 (1989).
9. KEOHAVONG, P. and THILLY, W.G., Mutational spectrometry: a general approach for hotspot point mutations in selectable genes. Proc. nat. Acad. Sci. (Wash.), 89, 4623-1627 (1992).
10. KOBAYASHI, T., TSUDA, H., NOGUCHI, M., HIROHASHI, S., SHIMOSATO, Y., GOYA, T. and HAYATA, Y., Association of point mutation in c-K-ras oncogene in lung adenocarcinoma with particular reference to cytologic subtypes. Cancer, 66, 289-294 (1990).
11. KUMAR, R. and DUNN, L., Designed diagnostic restriction fragment length polymorphism for the detection of point mutations in ras oncogenes. Oncogene Res., 1, 235-241 (1989).
12. LI, Z.-H., ZHENG, J., WEISS, L.M. and SHIBATA, D., c-K-ras and p53 mutations occur very early in adenocarcinoma of the lung. Amer. J. Pathol., 144, 303-309 (1994).
13. LOEB, L.A. and KUNKEL, T.A., Fidelity of DNA synthesis. Ann. Rev. Biochem., 52, 429-457 (1982).
14. MAO, L., HRUBAN, R.H., BOYLE, J.O., TOCKMAN, M. and SIDRANSKY, D., Detection of oncogene mutations in sputum precedes diagnosis of lung cancer. Cancer Res., 54, 1634-1637 (1994).
15. MILLS, N.E., FISHMAN, C.L., ROM, W.N., DUBIN, N. and JACOBSON, D.R., Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma. Cancer Res., 55, 1444-1447 (1995a).
16. MILLS, N.E., FISHMAN, C.L., SCHOLES, J., ANDERSON, S.E., ROM, W.N., DUBIN, N. and JACOBSON, D.R., Detection of K-ras oncogene mutations in bronchoalveolar lavage fluid for lung cancer diagnosis. J. nat. Cancer Inst., 87, 1056-1060 (1995b).
17. MITSUDOMI, T., VIALLET, J., MULSHINE, J.L., LINNOILA, R.I., MINNA, J.D. and GAZDAR, A.F. Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines. Oncogene, 6, 1353-1362 (1991).
18. MULLIS, K.B. and FALOONA, F.A., Specific synthesis of DNA in vitro via a catalyzed polymerase chain reaction. Methods Enzymol., 155, 335-350 (1987).
19. RODENHUIS, S. and SLEBOS, R.J., Clinical significance of ras oncogene activation in human lung cancer. Cancer Res., 52, 2665s-2669s (1992).
20. RODENHUIS, S., SLEBOS, R.J., BOOT, A.J.M., EVERS, S.G., MOI, W.J., WAGENAAR, S.S., VAN BODEGOM, P.C. and BOS, J.L., Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung. Cancer Res., 48, 5738-5741 (1988).
21. ROSELL, R., LI, S., SKACEL, Z., MATE, J.L., MAESTRA, J., CANELA, M., TOLOSA, E., ARMENGOL, P., BARNADAS, A. and ARIZA, A., Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients. Oncogene, 8, 2407-2412 (1993).
22. ROSELL, R., MONZO, M., PIFARRE, A., ARIZA, A., SANCHEZ, J.J., MORENO, I., MAUREL, J., LOPEZ, M.P., ABAD, A. and DE ANTA, J.M., Molecular staging of non-small cell lung cancer according to K-ras genotypes. Clin. Cancer Res., 2, 1083-1086 (1996).
23. SAIKI, R.K., GELFAND, D.H., STOFFEL, S., SCHARF, S.G., HIGUCHI, R., HORN, G.T., MULLIS, K.B. and ERLICH, H.A., Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Sicience, 239, 487-491 (1988).
24. SHEFFEILD, V.C., COX, D.R., LERMAN, L.S. and MYERS, R.M., Attachment of a 40-base-pair G+C rich sequence to genomic DNA fragments by polymerase chain reaction results in improved detection of single base changes. Proc. nat. Acad. Sci. (Wash.), 86, 232-23 (1991).
25. SUGIO, K., ISHIDA, T., YOKOYAMA, H., INOUE, T., SUGIMACHI, K. and SASAZUKI, T., ras gene mutation as a prognostic marker in adenocarcinoma of the human lung without lymph node metastasis. Cancer Res., 52, 2903-2906 (1992).
26. SUGIO, K., KISHIMOTO, Y., VIRMANI, A.K., HUNG, J.Y. and GAZDAR, A.F., K-ras mutations are a relatively late event in the pathoyenesis of lung carcinoma. Cancer Res., 54, 5811-5815 (1944).
27. SUZUKI, Y., ORITA, M., SHIRAISHI, M., HAYASHI, K. and SEKIYA, T., Detection of ras gene mutations in human lung cancers by single-strand conformation polymorphism analysis of polymerase chain reaction products. Oncogene, 5, 1037-1043 (1990).
28. WACHTENHEIM, J., HORAKOVA, I., NOVOTNA, H., OPALKA, P. and ROUBKOVA, H., Mutations of the ras-oncogene and absence of H-ras mutations in squamous cell carcinoma of the lung. Clin. Cancer Res., 1, 359-365 (1995).