Oral inoculation of sheep with the agent of bovine spongiform encephalopathy (BSE). 1. Onset and distribution of disease-specific PrP accumulation in brain and viscera

Journal of Comparative Pathology

Volumn 124, Issue 4, 2001, Pages 280-289

  Jeffrey, M ^a   Ryder, S ^a   Martin, S ^a   Hawkins, S A C ^a   Terry, L ^a   Berthelin Baker, C ^a   Bellworthy, S J ^a  

^a VETERINARY LABORATORIES AGENCY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BOVINE SPONGIFORM ENCEPHALOPATHY; BRAIN; CATTLE; CELL TYPE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE COURSE; DISEASE MARKER; DISEASE SIMULATION; DISEASE TRANSMISSION; EXPERIMENTAL INFECTION; GENOTYPE; IMMUNOHISTOCHEMISTRY; INOCULATION; LYMPH NODE; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRION; RETICULOENDOTHELIAL SYSTEM; SHEEP; SPINAL CORD; VISCERA;

EID: 0034941197     PISSN: 00219975     EISSN: None     Source Type: Journal    
DOI: 10.1053/jcpa.2001.0465     Document Type: Article

References (25)

1. Cerebral targeting indicates vagal spread of infection in hamsters fed with scrapie
2. Transmission of bovine spongiform encephalopathy and scrapie to mice: Strain variation and the species barrier
3. Transmissions to mice indicate that "new variant" CJD is caused by the BSE agent
4. Detection of BSE infectivity in brain and spleen of experimentally infected sheep
5. Transmission of bovine spongiform encephalopathy to sheep and goats
6. PrP genotype and agent effects in scrapie: Change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie
7. Deposition of disease-associated prion protein involves the peripheral nervous system in experimental scrapie
8. A comparative study of immunohistochemical methods for detecting abnormal prion protein with monoclonal and polyclonal antibodies
9. Hydrated autoclave pretreatment enhancement of prion protein immunoreactivity in formalin-fixed bovine spongiform encephalopathy-affected brain
10. Epidemiology of scrapie in the United States
11. Natural scrapie and PrP genotype: Case control studies in British sheep
12. res in murine ME7 scrapie in relation to pathological and PrP immunohistochemical changes
13. Sites of prion protein accumulation in scrapie infected mouse spleen revealed by immunogold electron microscopy
14. Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein
15. Pathogenesis of the oral route of infection of mice with scrapie and bovine spongiform encephalopathy agents
16. Pathological PrP is abundant in sympathetic and sensory ganglia of hamsters fed with scrapie
17. PrP genotypes and experimental scrapie in orally inoculated Suffolk sheep in the United States
18. Immunohistochemical detection of PrP in the medulla oblongata of sheep: The spectrum of staining in normal and scrapie affected sheep
19. Preclinical test for prion diseases
20. sc detection in the preclinical diagnosis of scrapie
21. Immunohistochemical detection of prion protein in lymphoid tissues of sheep with natural scrapie
22. Scrapie-associated prion protein in the gastrointestinal tract of sheep with natural scrapie
23. Preliminary observations on the pathogenesis of experimental bovine spongiform encephalopathy (BSE); An update
24. Bovine spongiform encephalopathy: Epidemiological studies on the origin
25. Bovine spongiform encephalopathy: Epidemiological features 1985 to 1990