Pathological PrP is abundant in sympathetic and sensory ganglia of hamsters fed with scrapie

Neuroscience Letters

Volumn 265, Issue 2, 1999, Pages 135-138

  McBride, Patricia A ^a   Beekes, Michael ^b  

^a INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^b ROBERT KOCH INSTITUTE   (Germany)

Author keywords

Hamster scrapie; Neuroanatomical targeting; Peripheral nervous system; PrP; Routing of infection

Indexed keywords

PRION PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELIAC GANGLION; CONTROLLED STUDY; NEUROTROPISM; NODOSE GANGLION; NONHUMAN; PRION; PRIORITY JOURNAL; SCRAPIE; SENSORY GANGLION; SPINAL GANGLION; SYMPATHETIC GANGLION; SYRIAN HAMSTER; VIRUS DETECTION;

EID: 0033574604     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00223-2     Document Type: Article

References (18)

1. Baldauf E., Beekes M., Diringer H. Evidence for an alternative direct route of access for the scrapie agent to the brain bypassing the spinal cord. J. Gen. Virol. 78:1997;1187-1197.
2. Beekes M., Baldauf E., Diringer H. Sequential appearance and accumulation of pathognomonic markers in the central nervous system of hamsters orally infected with scrapie. J. Gen. Virol. 77:1996;1925-1934.
3. Beekes M., McBride P.A., Baldauf E. Cerebral targeting indicates vagal spread of infection in hamsters fed with scrapie. J. Gen. Virol. 79:1998;601-607.
4. Bruce M.E., Will R.G., Ironside J.W., McConnell I., Drummond D., Suttie A., McCardle L., Chree A., Hope J., Birkett C., Cousens S., Fraser H., Bostock C.J. Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent. Nature. 389:1997;498-501.
5. Fraser H., Brown K.L., Stewart K., McConnell I., McBride P., Williams A. Replication of scrapie in spleens of SCID mice follows reconstitution with wild-type mouse bone marrow. J. Gen. Virol. 77:1996;1935-1940.
6. Fraser H., Bruce M.E., Davies D., Farquhar C.F., McBride P.A. The lymphoreticular system in the pathogenesis of scrapie. Prusiner S.B., Collinge J., Powell J., Anderton B. Prion Diseases of Humans and Animals. 1992;308 Ellis Horwood, Chichester.
7. Groschup M.H., Weiland F., Straub O.C., Pfaff E. Detection of scrapie agent in the peripheral nervous system of a diseased sheep. Neurobiol. Dis. 3:1996;191-195.
8. Hadlow W.J., Kennedy R.C., Race R.E. Natural infection of Suffolk sheep with scrapie virus. J. Infect. Dis. 146:1982;657-664.
9. Hill A.F., Desbruslais M., Joiner S., Sidle K.C.L., Gowland I., Collinge J., Doey L.J., Lantos P. The same prion strain causes vCJD and BSE. Nature. 389:1997;448-450.
10. Kascsak R.J., Rubenstein R., Mertz P.A., Tonna-Demasi M., Fersko R.M., Carp R.I., Wisniewski H.M., Diringer H. Mouse polyclonal and monoclonal antibody to scrapie-associated fibril protein. J. Virol. 61:1987;3688-3693.
11. Kimberlin R.H., Walker C.A. Pathogenesis of mouse scrapie: patterns of agent replication in different parts of the CNS following intraperitoneal infection. J. R. Soc. Med. 75:1982;618-624.
12. Kimberlin R.H., Walker C.A. Pathogenesis of scrapie (strain 263K) in hamsters infected intracerebrally, intraperitoneally or intraocularly. J. Gen. Virol. 67:1986;255-263.
13. Kimberlin R.H., Walker C.A. The role of the spleen in the neuroinvasion of scrapie in mice. Virus Res. 12:1989;201-212.
14. Kimberlin R.H., Walker C.A. Pathogenesis of scrapie in mice after intragastric infection. Virus Res. 12:1989;213-220.
15. Kimberlin R.H., Field H., Walker C.A. Pathogenesis of mouse scrapie: Evidence for spread of infection from central to peripheral nervous system. J. Gen. Virol. 64:1983;713-716.
16. McBride P.A., Wilson M.I., Eikelenboom P., Tunstall A., Bruce M.E. Heparan sulphate proteoglycan is associated with amyloid plaques and neuroanatomically targeted PrP pathlogy throughout the incubation period of scrapie-infected mice. Exp. Neurol. 149:1998;447-454.
17. Muramoto T., Kitamoto T., Tateishi J., Goto I. Accumulation of abnormal prion protein in mice infected with Creutzfeldt-Jakob disease via intraperitoneal route: a sequential study. Am. J. Pathol. 143:1993;1470-1479.
18. Wells G.A.H., Hawkins S.A.C., Green R.B., Austin A.R., Dexter I., Spencer Y.I., Chaplin M.J., Stack M.J., Dawson M. Preliminary observations on the pathogenesis of experimental bovine spongiform encephalopathy (BSE): an update. Vet. Rec. 142:1998;103-106.