Relaxation to authentic nitric oxide and SIN-1 in rat isolated mesenteric arteries: Variable role for smooth muscle hyperpolarization

British Journal of Pharmacology

Volumn 133, Issue 5, 2001, Pages 665-672

  Plane, Frances ^a,b   Sampson, Laura J ^a   Smith, Jennifer J ^a   Garland, Christopher J ^a,b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b University of Bath   (United Kingdom)

Author keywords

Nitric oxide; Potassium channels; Soluble guanylyl cyclase; Vascular smooth muscle

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; CALCIUM; CHARYBDOTOXIN; CYCLIC GMP; GUANYLATE CYCLASE INHIBITOR; LINSIDOMINE; NITRIC OXIDE; PHENYLEPHRINE; POTASSIUM; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTERY TONE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIUM CELL; HYPERPOLARIZATION; INHIBITION KINETICS; MALE; MEMBRANE POTENTIAL; MESENTERIC ARTERY; NONHUMAN; OXIDATIVE STRESS; POTASSIUM TRANSPORT; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SMOOTH MUSCLE RELAXATION; VOLTAGE CLAMP;

EID: 0034938659     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704127     Document Type: Article

References (35)

1. + channels
2. Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive potassium channel by cGMP-dependent protein kinase
3. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle
4. Increased nitrovasodilator sensitivity in endothelial nitric oxide synthase knockout mice: Role of soluble guanylyl cyclase
5. + channels of human and rabbit erythrocytes display distinctive patterns of inhibition by venom peptide toxins
6. Modulation of the vasodilator action of SIN-1 by the endothelium
7. + current
8. Nitric oxide is the mediator of both endothelium-dependent relaxation and hyperpolarisation of the rabbit coronary artery
9. Regulation of the sarcoplasmic reticulum protein phosphorylation by localized cyclic GMP-dependent protein kinase in vascular smooth muscle cells
10. + is an endothelium-derived hyperpolarizing factor in rat arteries
11. Donors of nitrogen oxides
12. Evidence that nitric oxide does not mediate the hyperpolarisation and relaxation to acetylcholine in the rat small mesenteric artery
13. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one
14. Endothelium-dependent hyperpolarization of smooth muscle cells in rabbit femoral arteries is not mediated by EDRF (nitric oxide)
15. Signal transduction mechanisms involving nitric oxide
16. High-conductance calcium activated potassium channels; structure, pharmacology and function
17. + channels in vasodilation induced by nitroglycerine, acetylcholine and nitric oxide
18. Ca) channels in myocytes of the guinea-pig taenia caeci
19. Nitric oxide and sodium nitroprusside-induced relaxation of the human umbilical artery
20. Ca) in smooth muscle cells isolated from rat mesenteric artery
21. Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo
22. Nitric oxide hyperpolarizes rabbit mesenteric arteries via ATP-sensitive potassium channels
23. Ca channel diversity and smooth muscle cell function
24. Interactions between membrane potential and intracellular calcium concentration in vascular smooth muscle
25. + channel from vascular and visceral smooth muscles
26. Differential effects of acetylcholine, nitric oxide and levcromakalim on smooth muscle membrane potential and tone in the rabbit basilar artery
27. Evidence that potassium channels make a major contribution to SIN-1-evoked relaxation of rat isolated mesenteric artery
28. Multiple pathways underlying endothelium-dependent relaxation in the rabbit isolated femoral artery
29. Evidence that different mechanisms underlie smooth muscle relaxation to nitric oxide and nitric oxide donors in the rabbit isolated carotid artery
30. cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells
31. + channels cloned from smooth muscle
32. Hyperpolarization and relaxation of arterial smooth muscle caused by nitric oxide derived from the endothelium
33. Nitric oxide lowers the calcium sensitivity of tension in the rat tail artery
34. + channel genes in mesenteric artery smooth muscle cells
35. v and Kca channels antagonizes NO-induced relaxation in pulmonary artery