Evidence that potassium channels make a major contribution to SIN-1-evoked relaxation of rat isolated mesenteric artery

British Journal of Pharmacology

Volumn 119, Issue 8, 1996, Pages 1557-1562

  Plane, Frances ^a   Hurrell, Amber ^a   Jeremy, Jamie Y ^b   Garland, Christopher J ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b BRISTOL ROYAL INFIRMARY   (United Kingdom)

Author keywords

Cyclic GMP; Endothelium; Nitric oxide; Vascular smooth muscle

Indexed keywords

8 BROMO CYCLIC GMP; APAMIN; ARGININE; CHARYBDOTOXIN; CYCLIC GMP; GLIBENCLAMIDE; LINSIDOMINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PHENYLEPHRINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM ION; QUINOXALINE DERIVATIVE; SUPEROXIDE DISMUTASE;

ANIMAL TISSUE; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; MALE; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030467946     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb16072.x     Document Type: Article

References (12)

1. BOLOTINA, V.M., NAJIBI, S., PALACINO, J.J., PAGANO, P.J. & COHEN, R.A. (1994). Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature, 368, 850-853.
2. BUSSE, R., POHL, U., MULSCH, A. & BASSENGE, E. (1990). Modulation of the vasodilator action of SIN-1 by the endothelium. J. Cardiovasc. Pharmacol., 14 (Suppl. 11), S81-S85.
3. GARLAND, C.J. & MCPHERSON, G.A. (1992). Evidence that nitric oxide does not mediate the hyperpolarization and relaxation to acetylcholine in the rat small mesenteric artery. Br. J. Pharmacol., 105, 429-435.
4. GARTHWAITE, J., SOUTHAM, E., BOULTON, C.L., NIELSEN, E.B., SCHMIDT, K. & MAYER, B. (1995). Potent and selective inhibition of nitric-oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol. Pharmacol., 48, 184-188.
5. GEORGE, M.J. & SHIBATA, E.F. (1995). Regulation of calcium-activated potassium channels by S-nitrosothiol compounds and cyclic guanosine monophosphate in rabbit coronary artery myocytes. J. Invest. Med., 43, 451-458.
6. IGNARRO, L.J. (1990). Haem-dependent activation of guanylate cyclase and cyclic GMP formation by endogenous nitric oxide: A unique transduction mechanism for transcellular signalling. Pharmacol. Toxicol., 67, 1-7.
7. MILLER, M.A.W., MORGAN, R.J., THOMPSON, C.S., MIKHAILIDIS, D.P. & JEREMY, J.Y. (1994). Adenylate and guanylate cyclase activity in the penis and aorta of the diabetic rat: an in vitro study. Br. J. Urol., 74, 106-111.
8. MURPHY, M.E. & BRAYDEN, J.E. (1995). Nitric oxide hyperpolarizes rabbit mesenteric arteries via ATP-sensitive potassium channels. J. Physiol., 486, 47-58.
9. PLANE, F., PEARSON, T. & GARLAND, C.J. (1994). Multiple pathways underlying endothelium-dependent relaxation in the rabbit isolated femoral artery. Br. J. Pharmacol., 115, 31-38.
10. PLANE, F., HURRELL, A. & GARLAND, C.J. (1996). Evidence for the involvement of potassium channels in the relaxation of rat isolated mesenteric arteries to the NO donor SIN-1. Br. J. Pharmacol., 119, 79P.
11. ROBERTSON, B.E., SCHUBERT, R., HESCHELER, J. & NELSON, M.T. (1993). cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle. Am. J. Physiol., 265, C299-C303.
12. ZYGMUNT, P.M. & HOGESTATT, E.D. (1996). Role of potassium channels in endothelium-dependent relaxation resistant to nitroarginine in the rat hepatic artery. Br. J. Pharmacol., 117, 1600-1606.