Immortalized testis cell lines from estrogen receptor (ER) α knock-out and wild-type mice expressing functional ERα or ERβ

Journal of Andrology

Volumn 22, Issue 4, 2001, Pages 652-664

  Mueller, S O ^a   Korach, K S ^a  

^a Knoll AG   (Germany)

Author keywords

HPV E6 E7; Immortalization; In vitro models; Leydig cells; Sertoli cells; ERKO

Indexed keywords

ANDROGEN RECEPTOR; CYCLIC AMP; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MESSENGER RNA;

ANIMAL CELL; ARTICLE; ATROPHY; CELL IMMORTALIZATION; CELL LINE; ESTROGEN ACTIVITY; GENE EXPRESSION; IN VITRO STUDY; KNOCKOUT MOUSE; LEYDIG CELL; MALE; MORPHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SERTOLI CELL; TESTIS CELL; TESTIS FUNCTION; WART VIRUS;

AGE FACTORS; ANIMALS; CELL LINE, TRANSFORMED; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GENE EXPRESSION; LEYDIG CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, ESTROGEN; RNA, MESSENGER; SERTOLI CELLS; SEXUAL MATURATION;

EID: 0034936257     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. The potential roles of estrogens in regulating Leydig cell development and function: A review
2. Characterization of several clonal lines of cultured Leydig tumor cells: Gonadotropin receptors and steroidogenic responses
3. Expression of SGP-1 mRNA in preimplantation mouse embryos
4. Sources of oestrogen in the testis and reproductive tract in the male
5. A tumor-specific truncated estrogen receptor splice variant enhances estrogen-stimulated gene expression
6. Environmental hormones and the male reproductive system
7. Biosynthesis and molecular cloning of sulfated glycoprotein 2 secreted by rat Sertoli cells
8. Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene
9. Estrogen receptor null mice: What have we learned and where will they lead us?
10. Tissue distribution and quantitative analysis of estrogen receptor-a (ERa) and estrogen receptor-b (ERb) messenger ribonucleic acid in the wild-type and ERa-knockout mouse
11. Are sperm counts really falling?
12. Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility
13. The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells
14. The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells
15. Monoclonal antibodies against rat Leydig cell surface antigens
16. The heterogeneity of isolated adult rat Leydig cells separated on percoll density gradients: An immunological, cytochemical, and functional analysis
17. A role for oestrogens in the male reproductive system
18. Morphologic changes in efferent ductules and epididymis in estrogen receptor-alpha knockout mice
19. The anti-estrogens ICI 182,780 and tamoxifen modulate N- and E- cadherin expression in the rat testis
20. Expression of estrogen receptor beta is developmentally regulated in reproductive tissues of male and female mice
21. Development and characterization of a prepubertal rat Sertoli cell line, 93RS2
22. Estrogen receptor gene disruption: Molecular characterization and experimental and clinical phenotypes
23. Establishment and characterization of testicular cell lines from MT-PVLT-10 transgenic mice
24. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene
25. Estrogens potentiate the stimulatory effects of follicle- stimulating hormone on N-cadherin messenger ribonucleic acid levels in cultured mouse Sertoli cells
26. Spermatogenic cells do not require estrogen receptor-alpha for development or function
27. Establishment and characterization of 2 distinct mouse testicular epithelial-cell Lines
28. Relationship of a mouse Sertoli cell line (MSC-1) to normal Sertoli cells
29. Improved retroviral vectors for gene transfer and expression
30. High specificity of Mullerian-inhibiting substance signaling in vivo
31. Expression and tissue distribution of rat sulfated glycoprotein-1 (prosaposin)
32. Distribution of mouse sulfated glycoprotein-1 (prosaposin) in the testis and other tissues
33. Identification of a third autonomous activation domain within the human estrogen receptor
34. Isolation, separation, and short-term culture of spermatogenic cells
35. Behavioral effects of estrogen receptor gene disruption in male mice
36. Modifications of testosterone-dependent behaviors by estrogen receptor alpha gene disruption in male mice
37. Transient coexpression of cytokeratin and vimentin in differentiating rat Sertoli cells
38. Regulation of expression of steroidogenic enzymes in Leydig cells
39. Directed expression of an oncogene to Sertoli cells in transgenic mice using mullerian inhibiting substance regulatory sequences
40. Receptors for anti-Mullerian hormone on Leydig cells are responsible for its effects on steroidogenesis and cell differentiation
41. Immortalization and characterization of a Sertoli cell line from the adult rat
42. Transcriptional control of high molecular weight keratin gene expression in multi-stage mouse skin carcinogenesis
43. Effect of anti-Mullerian hormone on Sertoli and Leydig cell functions in fetal and immature rats
44. Expression of oestrogen receptor beta (ER beta) occurs in multiple cell types, including some germ cells, in the rat testis
45. Targeted disruption of the estrogen receptor-alpha gene in female mice: Characterization of ovarian responses and phenotype in the adult
46. Rapid detection of octamer binding proteins with mini-extracts, prepared from a small number of cells
47. Comparative distribution of estrogen receptor-alpha (ER-alpha) and beta (ER-beta) mRNA in the rat pituitary, gonad, and reproductive tract
48. A monoclonal antibody against alpha-smooth muscle actin: A new probe for smooth muscle differentiation
49. Cellular localization and regulation of expression of testicular estrogen sulfotransferase
50. Cloning, chromosomal localization, and functional analysis of murine estrogen receptor b
51. Isolation and culture of testicular cells: A morphological characterization
52. Ontogeny of estrogen receptor-beta expression in rat testis
53. Local control systems within the testis
54. Effect of prenatal exposure to diethylstilbestrol on Mullerian duct development in fetal male mice
55. A potent specific pure anti-estrogen with clinical potential