p16/INK4a gene inactivation by hypermethylation is associated with aggressive variants of monoclonal gammopathies

Hematology Journal

Volumn 2, Issue 3, 2001, Pages 146-149

  Mateos, M V ^a   Garcia Sanz, R ^a   Lopez Perez R ^a   Balanzategui, A ^a   Gonzalez M I ^a   Fernandez Calvo J ^a   Moro, M J ^a   Hernandez J ^a   Caballero, M D ^a   Gonzalez M ^a   San Miguel, J F ^a  

^a HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

Author keywords

Methylation; Monoclonal gammopathies; p16 Gene

Indexed keywords

BISULFITE; CELL CYCLE PROTEIN; DNA; PROTEIN P16; RESTRICTION ENDONUCLEASE;

ARTICLE; CANCER PATIENT; CELL CYCLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE MODEL; DNA MODIFICATION; ENZYME ASSAY; GENE ACTIVITY; GENE INACTIVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALIGNANT TRANSFORMATION; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLE MYELOMA; ONCOGENE; OUTCOMES RESEARCH; PATHOGENESIS; PLASMA CELL LEUKEMIA; POLYMERASE CHAIN REACTION; PROTEIN METHYLATION; REGULATORY MECHANISM; SYMPTOM; TUMOR SUPPRESSOR GENE; WALDENSTROEM MACROGLOBULINEMIA;

CYCLIN-DEPENDENT KINASE INHIBITOR P16; DISEASE PROGRESSION; DNA; DNA METHYLATION; DNA, NEOPLASM; GENE SILENCING; GENES, P16; LEUKEMIA, PLASMACYTIC; MULTIPLE MYELOMA; NEOPLASM PROTEINS; PARAPROTEINEMIAS; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; SULFITES; WALDENSTROM MACROGLOBULINEMIA;

EID: 0034936152     PISSN: 14664860     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.thj.6200084     Document Type: Article

References (14)

1. Monoconal gammopathy of undetermined significance (MGUS): A review
2. Plasma cell myeloma. New biological insights and advances in therapy
3. Multiple Myeloma: Increasing evidence for a multistep transformation process
4. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4
5. Multiple mechanisms of p16/INK4a inactivation in non-small cell lung cancer cell lines
6. INK4c genes in multiple myeloma
7. Hypermethylation of p16 and p15 genes in Multiple Myeloma
8. INK4a gene in Multiple Myeloma
9. De Novo methylation of tumor suppressor gene p16/Ink4a is a frequent finding in Multiple Myeloma patients at diagnosis
10. Detection of single and associated lessions of the bcl-1, bcl-2, bcl-6, c-myc, MLL, p53 and p16 genes in B-cell non-Hodgkin's lymphoma. Value of molecular analysis for a better assignment of the histologic subtype
11. A cell cycle regulator potentially involved in genesis of many tumor types
12. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
13. INK4a gene inactivation by deletions, mutations and hypermethylation is associated with transformed and aggressive variants of Non-Hodgkin's Lymphomas
14. Role of the p16 tumor suppressor gene in cancer