In vivo dynamics of human stem cell repopulation in NOD/SCID mice

Annals of the New York Academy of Sciences

Volumn 938, Issue , 2001, Pages 184-190

  Dick, John E ^a,b   Guenechea, Guillermo ^a,b   Gan, Olga I ^a,b   Dorrell, Craig ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Gene transfer; Lentivirus; NOD SCID mice; Retrovirus; Stem cells

Indexed keywords

CELL COMPARTMENTALIZATION; CELL POPULATION; CELL PROLIFERATION; CONFERENCE PAPER; DYNAMICS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; SCID MOUSE;

EID: 0034935580     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2001.tb03588.x     Document Type: Conference Paper

References (23)

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6. Distinct classes of human stem cells that differ in proliferative and self-renewal potential
7. Clonal and systemic analysis of long-term hematopoiesis in the mouse
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11. Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/Wv mice
12. Developmental potential and dynamic behavior of hematopoietic stem Cells
13. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy
14. Efficient retroviral-mediated gene transfer to human cord blood stem cells with in vivo repopulating potential
15. low primitive cells capable of reconstituting long-term cultures in vitro and nonobese diabetic-severe combined immunodeficiency mice in vivo
16. High efficiency gene transfer to human hematopoietic SCID-repopulating cells under serum-free conditions
17. Highly efficient transduction of the green fluorescent protein gene in human umbilical cord blood stem cells capable of cobblestone formation in long-term cultures and multi-lineage engraftment of immunodeficient mice
18. One-day ex vivo culture allows effective gene transfer into human nonobese diabetic/severe combined immune-deficient repopulating cells using high-titer vesicular stomatitis virus G protein pseudotyped retrovirus
19. Efficient transduction of human hematopoietic repopulating cells generating stable engraftment of transgene-expressing cells in NOD/SCID mice
20. - cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: Dissociation of SRC phenotype and function
21. Sustained proliferation, multi-lineage differentiation and maintenance of primitive human haemopoietic cells in NOD/SCID mice transplanted with human cord blood
22. Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice
23. - bone marrow and cord blood-derived SCID-repopulating cells with third-generation lentiviral vectors