Potentiation of sildenafil-induced hypotension is minimal with nitrates generating a radical intermediate

Journal of Cardiovascular Pharmacology

Volumn 38, Issue 1, 2001, Pages 149-155

  Schwemmer, Michael ^a   Bassenge, Eberhard ^a   Stoeter, Michael ^a   Hartmann, Bernd ^a   Hess, Ulrich ^a   Fink, Bruno ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Erectile dysfunction; Hypotension; Nitrates; PETN Trinitrate radical; Sildenafil

Indexed keywords

GLYCERYL TRINITRATE; ISOSORBIDE DINITRATE; NITRIC ACID DERIVATIVE; NITRIC OXIDE; PENTAERYTHRITYL TETRANITRATE; SILDENAFIL;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DILATATION; DOG; DOSE RESPONSE; DRUG POTENTIATION; FEMALE; HEART RATE; HYPOTENSION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BLOOD PRESSURE; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FEMALE; FREE RADICALS; HEART RATE; HYPOTENSION; MALE; NITRATES; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES;

EID: 0034932972     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-200107000-00016     Document Type: Article

References (34)

1. Effects of nitrates in various vascular sections and regions
2. Dose-dependent effects of isosorbide-5-mononitrate on the venous, arterial and coronary arterial system of conscious dogs
3. Altered spectrum of nitroglycerin action in longterm treatment: Nitroglycerin-specific venous tolerance with maintenance of arterial vasodepressor potency
4. Overall cardiovascular profile of sildenafil citrate
5. Cyclic GMP phosphodiesterase-5: Target of sildenafil
6. Erectile dysfunction and sildenafil citrate and cardiologists
7. Sildenafil
8. Sildenafil citrate potentiates the hypotensive effects of nitric oxide donor drugs in male patients with stable angina
9. Formation of reactive oxygen species by PETN and GTN in vitro and development of nitrate tolerance
10. Comparison of glyceryl trinitrate-induced with pentaerythritol tetranitrate-induced in vivo formation of superoxide radicals: Effect of vitamin C
11. Nitrate tolerance in epicardial arteries or in the venous system is not reversed by N-acetylcysteine in vivo, but tolerance-independent interactions exist
12. Mechanisms of interaction between the sulfhydryl precursor L-methionine and glyceryl trinitrate
13. Dietary supplement with vitamin C prevents nitrate tolerance
14. Unexpected, tolerance-devoid vasomotor and platelet actions of pentaerythritol tetranitrate
15. Tolerance to nitrates and simultaneous upregulation of platelet activity prevented by enhancing antioxidant state
16. Sildenafil: A review of its use in erectile dysfunction
17. Sildenafil citrate and blood-pressure-lowering drugs: Results of drug interaction studies with an organic nitrate and a calcium antagonist
18. Diameters of abdominal veins and arteries during nitrate therapy
19. Effect of nitroglycerin on peripheral large arteries in hypertension
20. Nitrates for treatment of unstable angina pectoris and coronary vasospasm
21. Observations of arterial and venous vasomotion with the absolute induction angiometer
22. Coronary vasomotor responses: Role of endothelium and nitrovasodilators
23. Molsidomine
24. Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro
25. Sildenafil is a pulmonary vasodilator in awake lambs with acute pulmonary hypertension
26. Effects of sildenafil citrate on human hemodynamics
27. Long-term therapy of coronary artery disease: Loss of efficacy through development of tolerance?
28. Transient and sustained impacts of hydroxyl radicals on sarcoplasmic reticulum function: Protective effects of nebivolol
29. Direct evidence for increased hydroxyl radicals originating from superoxide in the failing myocardium
30. Selective effects of oxygen free radicals on excitation-contraction coupling in ventricular muscle. Implications for the mechanism of stunned myocardium
31. Neue chemosynthesen an PETN*-metaboliten und strukturanaloga
32. Chemosynthese von pentaerithrityltetranitrat-metaboliten und perspektiven strukturanaloger verbindungen
33. Self-reducing metabolism of PETN to NO associated with suppression of excessive O2 production in hypercholesterolemia