Differing processing requirements of four recombinant antigens containing a single defined T-cell epitope for presentation by major histocompatibility complex class II

Immunology

Volumn 103, Issue 3, 2001, Pages 343-350

  Colledge, Lisa ^a,b   Sun, Mei Yi ^c   Lin, Wei ^c   Clare Blackburn, C ^a,b   Reay, Philip A ^c  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b Centre for Genome Research   (United Kingdom)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C; EPITOPE; MAJOR HISTOCOMPATIBILITY ANTIGEN; MONOCLONAL ANTIBODY; PROTEINASE; RECOMBINANT ANTIGEN;

ANIMAL CELL; ANTIGEN BINDING; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN PRESENTATION; CHO CELLS; CRICETINAE; CYTOCHROME C GROUP; EPITOPES, T-LYMPHOCYTE; GLUTATHIONE TRANSFERASE; H-2 ANTIGENS; HISTOCOMPATIBILITY ANTIGENS CLASS II; RECOMBINANT PROTEINS;

EID: 0034932279     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2001.01254.x     Document Type: Article

References (42)

1. Sequence analysis of peptides bound to MHC class II molecules
2. Cathepsin D, but not cathepsin B, releases T cell stimulatory fragments from lysozyme that are functional in the context of multiple murine class II MHC molecules
3. Role of cathepsin D in antigen presentation of ovalbumin
4. Identification of proteases that process distinct epitopes on the same protein
5. Natural processing sites for human cathepsin E and cathepsin D in tetanus toxin: Implications for T cell epitope generation
6. Reduction of disulfide bonds within lysosomes is a key step in antigen processing
7. Reduction of disulfide bonds during antigen processing: Evidence from a thiol-dependent insulin determinant
8. Gallium arsenide modulates proteolytic cathepsin activities and antigen processing by macrophages
9. Peptide loading onto recycling HLA-DR molecules occurs in early endosomes
10. Presentation of antigens internalized through the B cell receptor requires newly synthesized MHC class II molecules
11. Determination of the relationship between T cell responsiveness and the number of MHC-peptide complexes using specific monoclonal antibodies
12. The nature of major histocompatibility complex recognition by gamma-delta T cells
13. Expression of a class 11 major histocompatibility complex (MHC) heterodimer in a lipid-linked form with enhanced peptide/soluble MHC complex formation at low pH
14. Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid
15. Long term storage of tumour-specific cytotoxic T cells
16. Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens
17. Two-dimensional nuclear magnetic resonance analysis of a labeled peptide bound to a class II major histocompatibility complex molecule
18. In vitro folding of inclusion body proteins
19. The purification of eukaryotic polypeptides synthesized in Escherichia coli
20. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
21. pH dependence and exchange of high and low responder peptides binding to a class II MHC molecule
22. T cell growth factor: Parameters of production and a quantitative microassay for activity
23. New class II-like genes in the murine MHC
24. A new human HLA class II-related locus, DM
25. Reconstitution of an operational MHC class II compartment in non-antigen-presenting cells
26. MHC class II-associated invariant chain contains a sorting signal for endosomal compartments
27. Intracellular transport of class II MHC molecules directed by invariant chain
28. MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding
29. The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route
30. d and HLA-DR1 by backbone-dependent and aromatic side chain-dependent interactions, respectively
31. Antigen conformation determines processing requirements for T-cell activation
32. Large protein fragments as substrates for endocytic antigen capture by MHC class II molecules
33. The handling of Listeria monocytogenes by macrophages: The search for an immunogenic molecule in antigen presentation
34. Capacity of intact proteins to bind to MHC class II molecules
35. Acidification and disulfide reduction can be sufficient to allow intact proteins to bind class II MHC
36. Amino terminal trimming of peptides for presentation on major histocompatibility complex class II molecules
37. Generation of an MHC class II-restricted T cell epitope by extracellular processing of hepatitis delta antigen
38. Abundant empty class II MHC molecules on the surface of immature dendritic cells
39. Rapid extracellular degradation of synthetic class I peptides by human dendritic cells
40. Extracellular antigen processing and presentation by immature dendritic cells
41. Functional HLA-DM on the surface of B cells and immature dendritic cells
42. Intracellular formation and cell surface expression of a complex of an intact lysosomal protein and MHC class II molecules