Identification of a novel CBFB-MYH11 transcript: Implications for RT-PCR diagnosis

Hematology Journal

Volumn 2, Issue 3, 2001, Pages 206-209

  Van der Reijden, B A ^a   de Wit, L ^a   van der Poel, S ^a   Luiten, E B ^a   Lafage Pochitaloff, M ^a   Dastugue, N ^a   Gabert, J ^a   Lowenberg B ^a   Jansen, J H ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

AML M4Eo; CBFB MYH11; Diagnosis; Inv(16); RT PCR; T(16; 16)

Indexed keywords

COMPLEMENTARY DNA; CORE BINDING FACTOR; CORE BINDING FACTOR BETA; MYOSIN HEAVY CHAIN; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; ARTICLE; CASE REPORT; CHROMOSOME 16; CHROMOSOME ANALYSIS; CHROMOSOME INVERSION; CHROMOSOME REARRANGEMENT; CHROMOSOME TRANSLOCATION 16; CLINICAL PROTOCOL; FLUORESCENCE IN SITU HYBRIDIZATION; FUSION GENE; GENE AMPLIFICATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; POLYMERASE CHAIN REACTION; PROGNOSIS; RELIABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CHROMOSOMES, HUMAN, PAIR 16; DNA MUTATIONAL ANALYSIS; DNA PRIMERS; HUMANS; INVERSION, CHROMOSOME; LEUKEMIA, MYELOMONOCYTIC, ACUTE; MALE; MIDDLE AGED; ONCOGENE PROTEINS, FUSION; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSLOCATION, GENETIC; TUMOR MARKERS, BIOLOGICAL;

EID: 0034930282     PISSN: 14664860     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.thj.6200103     Document Type: Article

References (24)

1. Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. A unique cytogenetic-clinicopathological association
2. Fusion between transcription factor CBFb/PEPB2b and a myosin heavy chain in acute myeloid leukemia
3. A gene for a myosin peptide is disrupted by the inv(16)(p13q22) in acute nonlymphocytic leukemia M4Eo
4. Detection of fusion transcripts generated by the inversion 16 chromosome in acute myelogenous leukemia
5. Detection of minimal residual disease in acute myelomonocytic leukemia with abnormal marrow eosinophils by nested polymerase chain reaction with allele specific amplification
6. Detection of the chromosome 16 CBFb-MYH11 fusion transcript in myelomonocytic leukemias
7. RT-PCR diagnosis of patients with acute nonlymphocytic leukemia and inv(16)(p13q22) and identification of new alternative splicing in CBFB-MYH11 transcripts
8. Simple method for detection of MYH11 DNA rearrangements in patients with inv(16)(p13q22) and acute myeloid leukemia
9. Two-color FISH detection of the inv(16) in interphase nuclei of patients with acute myeloid leukemia
10. Molecular pathogenesis of the chromosome 16 inversion in the M4Eo subtype of acute myeloid leukemia
11. Inversion of chromosome 16 and uncommon rearrangements of the CBFB and MYH11 genes in therapy-related acute myeloid leukemia: Rare events related to DNA-topoisomerase II inhibitors?
12. Identification of a novel CBFB-MYH11 fusion transcript in a patient with AML and inversion of chromosome 16
13. Allogeneic vs autologous stem cell transplantation vs chemotherapy in patients with acute myeloid leukemia in first remission: The BGMT 87 study
14. Human smooth muscle myosin heavy chain gene mapped to chromosomal region 16q12
15. Detection of CBFbeta/MYH11 fusion transcripts in acute myeloid leukemia: Heterogeneity of cytological and molecular characteristics
16. Establishment and characterization of a new human leukemia cell line derived from M4E0
17. NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3)
18. Novel CBFb-MYH11 fusion transcripts and alternative splicing in acute myeloid leukemia with inversion of chromosome 16
19. Heterogeneity in CBFb/MYH11 fusion messages encoded by the inv(16)(p13q22) and the t(16;16)(p13;q22) in acute myelogenous leukemia
20. Detection of CBFB/MYH11 transcripts in patients with inversion and other abnormalities of chromosome 16 at presentation and remission
21. Frequency of CBFB beta/MYH11 fusion transcripts in patients entered into the U.K. MRC AML trials
22. Acute leukemias with structurally altered core binding factor subunits t(8;21), inv(16), t(12;21)
23. Novel CBFB-MYH11 fusion transcripts or RT-PCR artifacts?
24. Identification of false-positive CBFbeta/MYH11 RT-PCR results